Metabolic study of trimetazidine using ultra-high performance liquid chromatography-tandem mass spectrometry
Kamila Chomaničová,
Élida Alechaga Silva,
Rosa Ventura Alemany
Abstract:In the present study, the application of ultra-high performance liquid chromatography-tandem mass spectrometry allowed us to study of known-as well as hitherto unknown-trimetazidine (TMZ) metabolites in human urine and to propose their renal excretion profiles. Urine samples from a healthy volunteer were analyzed at baseline and at 0-4 h, 4-8 h, 8-12 h, and 12-24 h after a single dose of TMZ. A dilute-and-shoot procedure was used as sample treatment before separation. Full-scan spectra of possible metabolites … Show more
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