Development and evaluation of wafer loaded with sertaconazole solid dispersion for the treatment of oral candidiasis

Hajhashemi, Horieh; Taymouri, Somayeh; Shafiee, Fatemeh

doi:10.1590/s2175-97902023e22452

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…The surfaces of the wafer tablets exhibited some cleavages, with the highest occurrence observed in F1. At higher magnification, a porous structure was observed, which is typically associated with lyophilized wafers [15][16][17][18][19][20]. In the case of F2, where the separation of cannabis extract occurred during the preparation, insoluble cannabis extract was observed on the surface of the wafer tablet.…”

Section: Appearance Of Orally Fast-disintegrating Wafer Tablets Conta...mentioning

confidence: 99%

Fabrication of Orally Fast-Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze-Drying Method

Monton,

Kulvanich,

Chankana

et al. 2024

Med Cannabis Cannabinoids

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Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery and to also enhance patient convenience. Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the freeze drying technique, were developed in this work. The formulation consisted of several key components: cannabis extract as the active compound, Tween® 80 as a surfactant and solubilizer, gelatin and mannitol as structural components, sucralose as a sweetening agent, and sodium methylparaben and sodium propylparaben as preservatives. Results: The optimized formulation consists of the following ingredients: 5% cannabis extract, 1.25% Tween® 80, 5% gelatin, 88.34% mannitol, 0.2% sucralose, 0.19% sodium methylparaben, and 0.02% sodium propylparaben. The resulting wafer tablets exhibited the following characteristics: a porous structure, an average weight of approximately 200 mg, minimal weight variation (less than 1.4%), slightly acidic pH (pH 5.12), disintegration within 10 s, low moisture content (less than 3%), a Δ9-tetrahydrocannabinol content of approximately 2.8 mg, and a cannabidiol content of approximately 0.9 mg. Additionally, the wafer tablets rapidly dissolved in simulated saliva fluid containing sodium lauryl sulfate. Conclusion: This work succeeded in the fabrication of orally disintegrating wafer tablets containing cannabis extract with desired properties.

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Section: Appearance Of Orally Fast-disintegrating Wafer Tablets Conta...mentioning

confidence: 99%

Fabrication of Orally Fast-Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze-Drying Method

Monton,

Kulvanich,

Chankana

et al. 2024

Med Cannabis Cannabinoids

View full text Add to dashboard Cite

show abstract

3D printing chronicles in medical devices and pharmaceuticals: tracing the evolution and historical milestones

Patel,

Shah

et al. 2024

Journal of Biomaterials Science, Polymer Edition

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Development and evaluation of wafer loaded with sertaconazole solid dispersion for the treatment of oral candidiasis

Cited by 2 publications

References 42 publications

Fabrication of Orally Fast-Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze-Drying Method

Fabrication of Orally Fast-Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze-Drying Method

3D printing chronicles in medical devices and pharmaceuticals: tracing the evolution and historical milestones

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