Investigation on formulation parameters of donepezil HCl loaded solid lipid nanoparticles
Gizem Rüya Topal,
Berrin Küçüktürkmen,
Umut Can Öz
et al.
Abstract:Donepezil-HCl is a member of the acetylcholinesterase inhibitors that is indicated for the symptomatic treatment of Alzheimer's disease (AD) and has many side effects. In this study, to reduce the side effects of Donepezil-HCl and increase the penetration of the drug through the blood-brain barrier, we aimed to design a solid lipid nanoparticle (SLN) formulation. The effects of the different formulation parameters, such as homogenization speed, sonication time, lipid and drug concentration, surfactant type and… Show more
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