Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery

Abstract

Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs. In this minireview, the functional properties of poloxamer for physicochemical modification, such as solubility and stability, and biological response modification, such as neuroprotection, cell apoptosis, efflux pump modification, membrane cell modification, and cellular uptake, are discussed to provide a broader understanding to assist the development of poloxamer-based formulations.

Poloxamer-Based Mixed Micelles Loaded with Thymol or Eugenol for Topical Applications

“…These aggregates can be easily fabricated from different types of polymer surfactants, including Poloxamers. These biocompatible polymers belong among the poly­(ethylene oxide)-poly­(propylene oxide)-poly­(ethylene oxide) (PEO–PPO-PEO) triblock copolymer surface active agents (Figure ) that can be used for the preparation of suitable carriers with an outer hydrophilic chain and inner hydrophobic core in an aqueous medium. , Compared to traditional low molecular weight surface active agents, Poloxamer molecules contain long chains with an M w of thousands g/mol. Poloxamer aggregates can form micelles, reversed micelles, and lyotropic liquid crystals, including lamellar, hexagonal, and cubic aggregates.…”

Priming of Pisum sativum seeds with stabilized Pluronic P85 nanomicelles: effects on seedling development and photosynthetic function

“…Pluronics (also called poloxamers) are biocompatible polymers, that are widely available, stable, easily soluble, and able to penetrate cellular membranes, which results in their vast application as safe drug carriers with site-specific and slow-release properties. The length of the individual blocks can moderate the specific physical characteristics and consequently the physiological function of the polymer (Ottenbrite and Javan 2005, reviewed in Yu et al 2021, Nugraha et al 2022.…”