Ethosomal gel: a novel choice for topical delivery of the antipsychotic drug Ziprasidone Hydrochloride

Avasarala, H; Dinakaran, Satish; Boddeda, Bhavani; Dasari, Surendra; Jayanthi, Vijaya Ratna; Swaroopa, P

doi:10.1590/s2175-97902022e19317

Cited by 1 publication

(2 citation statements)

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“…87 Moreover, they can cause skin irritation and erythema if they are not optimized, 88 and show some incompatibility with certain drugs. 89 The interference may have physical or chemical or therapeutic effects. This may alter the drug solubility, stability, or bioavailability.…”

Section: Limitati On S Of E Thosome S Deliverymentioning

confidence: 99%

“…In addition, there are limited in vivo studies that make it difficult to fully understand the potential benefits and risks of using ethosomes as a drug delivery system 87 . Moreover, they can cause skin irritation and erythema if they are not optimized, 88 and show some incompatibility with certain drugs 89 . The interference may have physical or chemical or therapeutic effects.…”

Section: Limitations Of Ethosomes Deliverymentioning

confidence: 99%

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Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review

Abu‐Huwaij

Zidan

2023

J of Cosmetic Dermatology

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BackgroundIn a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.MethodThis review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The focus is on exploring their applications in various pathologies, particularly skin disorders such as acne, hair loss, and skin pigmentation.ResultsEthosomes are a novel type of vesicular nanocarrier composed of high concentrations of ethanol (20‐45%) and phospholipids. Their unique structure and composition make them an ideal choice for transporting active ingredients through the skin, offering targeted and effective treatment. The inclusion of ethanol in ethosomes' composition gives them distinctive properties, including flexibility, deformability, and stability, facilitating deep penetration into the skin and enhancing medication deposition. Moreover, ethosomes improved theoverall drug‐loading capacity, and specificity of target treatmentConclusionEthosomes represent a unique and suitable approach for delivering active cosmetic ingredients in the treatment of hair loss, acne, and skin whitening, presenting a versatile alternative to traditional dermal delivery systems. Despite the challenges associated with their complex preparation and sensitivity to temperature and humidity, the remarkable potential benefits of ethosomes cannot be ignored. Further research is crucial to unlock their full potential, understand their limitations, and refine their formulations and administration methods. Ethosomes hold the promise of transforming the way we address these cosmetic concerns, offering an exciting glimpse into the future of advanced skincare solutions.

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Section: Limitati On S Of E Thosome S Deliverymentioning

confidence: 99%

Section: Limitations Of Ethosomes Deliverymentioning

confidence: 99%