The benefit of Silybum marianum in ethanol-induced reprotoxicity of male Wistar rat

Talbi, Amina; Khelili, Kamel; Remita, Feriel; Abdennour, Cherif

doi:10.1590/s2175-97902022e19264

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…The obtained data showed that SMSE treatment at high concentrations resulted in a significant improvement in FI, BWG, and FER than at low SMSE concentrations in B[a]P-treated rats. Talbi et al [45] observed that S. marianum seeds-infused solution (200 mg/kg/day) exhibited no significant difference between all groups of ethanol-induced reprotoxicity in male rats in terms of body weight gain. Furthermore, Aghazadeh et al [46] reported that administering S. marianum extract at a dosage equivalent to 1.0 g seeds powder/kg b. wt./d for three weeks had no significant effect on food consumption and body weight among nonalcoholic steatohepatitis-treated rats.…”

Section: Effect Of Smse On Bwg Fi and Fer Of B[a]ptreated Ratsmentioning

confidence: 99%

Attenuation of Benzo[a]Pyrene-Induced Oxidative Stress and Cell Apoptosis in Albino Rats by Wild Milk Thistle (Silybum Marianum L.) Seeds Extract

Mahran,

El-Hassanen

2023

Egypt. J. Chem.

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Oxidative stress (OS) is considered a pathogenic mechanism that, if not strictly controlled, triggers the onset and progression of many chronic and degenerative diseases. This investigation aimed to explore the potential attenuation of OS and cell apoptosis induced by benzo[a]pyrene (B[a]P) in albino rats using wild Silybum marianum seed ethanolic extract (SMSE). Thirty-six adult male albino rats were divided into six equal groups. Group (1) served as the normal control and received an intraperitoneal vehicle of single-dose corn oil (10 ml/kg/b. wt.). The remaining groups (2-6) were subjected to a single dose of B[a]P (125 mg/kg/b. wt.) dissolved in corn oil. Subsequently, group (2) was assigned as the positive control, while the other groups (3 to 6) received SMSE at doses of 200, 400, 600, and 800 mg/kg/d, respectively, by oral gavage for four weeks. B[a]P administration resulted in severe OS as evidenced by a significant (p≤0.05) increase in plasma oxidants levels (thiobarbituric acid reactive substances TBARS, No2, and No2/No3); and a marked drop in the levels of erythrocyte enzymatic antioxidants (glutathione peroxidase GSH-Px, catalase CAT, and superoxide dismutase SOD), non-enzymatic antioxidants (reduced glutathione GSH and oxidized glutathione GSSG) and plasma antioxidant vitamins (A, C, and E). Additionally, B[a]P exposure activated liver apoptosis by upregulating caspase-3 (a cell apoptosis executor) and Bax (a pro-apoptotic protein); and downregulating Bcl-2 (an anti-apoptosis marker). Treatment with SMSE markedly attenuated OS by suppressing plasma oxidants or restoring enzymatic and non-enzymatic antioxidant armories in a concentration-dependent manner. Moreover, the apoptotic proteins caspase-3 and Bax were inhibited, whereas the anti-apoptotic mediator Bcl-2 was activated. In conclusion, the obtained data provide potent proof of SMSE's efficiency as a preventative and curative natural remedy against B[a]P-induced oxidative stress damages.

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Section: Effect Of Smse On Bwg Fi and Fer Of B[a]ptreated Ratsmentioning

confidence: 99%

Attenuation of Benzo[a]Pyrene-Induced Oxidative Stress and Cell Apoptosis in Albino Rats by Wild Milk Thistle (Silybum Marianum L.) Seeds Extract

Mahran,

El-Hassanen

2023

Egypt. J. Chem.

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“…The harmful impact of ethanol may occur via modification of the NO pathway, which eventually indirectly leads to the prevention of GnRH secretion (Finelli et al, 2021). In addition, ethanol is involved in increasing the rate of testosterone removal as well as suppressing testosterone synthesis-related enzymes (Talbi et al, 2022). Additionally, ethanol intake can stimulate the production of prolactin, causing hypogonadism and the subsequent reduction in gonadal hormones and impaired spermatogenesis (Rachdaoui and Sarkar, 2017).…”

Section: Effects Of Different Treatments On Testicular Dna Content An...mentioning

confidence: 99%

Myrrh Attenuates Gonadal Toxicity and DNA Fragmentation Induced by Ethanol in Male Rats

Alahmari

2023

IJAR

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Background: Long-term ethanol consumption causes pathological alterations to the male reproductive system, possibly resulting in infertility. Myrrh is a resin with antioxidant properties that is produced from the bark of Commiphora tree species. This research aimed to observe the protective impact of myrrh extract supplementation on male reproductive injury and toxicity induced by ethanol treatment. Methods: Adult male Sprague Dawley rats were orally treated with 40% ethanol (3 g/kg) in combination with myrrh extract (500 mg/kg) for four weeks to investigate the curative efficiency of myrrh extract against ethanol toxicity from physiological, histopathological and genetic aspects. Result: The findings revealed that the sperm count, testosterone level and DNA concentration diminished significantly in the ethanol-treated rats compared to control rats, while the contents of malondialdehyde (MDA), heat shock protein 70 (HSP70) and proinflammatory mediators, including tumor necrosis factor-α (TNF-α) and nitric oxide (NO), were elevated significantly; severe degenerative changes in the testicular structure and strong testicular DNA fragmentation were also observed. Co-treatment with myrrh attenuated lipid peroxidation and improved testicular histomorphology, testosterone levels and DNA concentrations and pattern, while at the same time, the levels of both HSP70 and TNF-α levels were increased. Our results provide insight into the curative impacts of myrrh on ethanol toxicity resulting from the rich content of curzerene in myrrh, which has antioxidant activities.

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The benefit of Silybum marianum in ethanol-induced reprotoxicity of male Wistar rat

Cited by 2 publications

References 34 publications

Attenuation of Benzo[a]Pyrene-Induced Oxidative Stress and Cell Apoptosis in Albino Rats by Wild Milk Thistle (Silybum Marianum L.) Seeds Extract

Attenuation of Benzo[a]Pyrene-Induced Oxidative Stress and Cell Apoptosis in Albino Rats by Wild Milk Thistle (Silybum Marianum L.) Seeds Extract

Myrrh Attenuates Gonadal Toxicity and DNA Fragmentation Induced by Ethanol in Male Rats

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