Analgesic, antipyretic, anti-inflammatory, and hepatoprotective activities of Pulicaria crispa (Forssk.) Oliv. (Asteraceae)

Soliman, Gamal A.; Ansari, Mohd Nazam; Alqarni, Mohammed H.; Foudah, Ahmed I.; Alam, Aftab; Salkini, Mohammed Ayman; Yusufoğlu, Hasan Soliman

doi:10.1590/s2175-97902022e18851

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…For example, chrysanthemum is widely used to treat throat inflammation, fever, headache, and oral ulcers [24], and dandelion is used to treat upper respiratory tract infections, lung infections, and purulent diseases [25]. Modern pharmacological studies have indicated that Asteraceae plants possess anti-cancer, cardiovascular-protective, hepatoprotective, anti-diabetic, anti-bacterial, and anti-viral properties [26][27][28][29][30][31]. Chemical investigations have been widely performed on Asteraceae plants to identify terpenoids, flavonoids, lignans, polyacetylenes, and polyphenols.…”

Section: Introductionmentioning

confidence: 99%

Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review

Chen,

Feng,

Petrović

et al. 2023

Acta Materia Medica

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Inflammation is an essential part of the immune response to injury and infection. Emerging evidence indicates that long-term low-grade inflammation is positively correlated with many diseases, such as cancer, metabolic disorders, and cardiovascular diseases. Due to common anti-inflammatory drugs are suitable for treating acute inflammation and cause severe adverse effects, new safe and effective drug candidates are urgently needed for treating chronic inflammation. Plants of the Asteraceae family have been widely used in traditional medicines for relieving fever symptoms and killing pathogens. The anti-inflammatory properties of sesquiterpenoids from plants in the Asteraceae family have attracted increasing attention in recent decades because of their structural complexity and potent bioactivities. Herein, we provide a comprehensive and up-to-date summary of sesquiterpenoids from the Asteraceae family with anti-inflammatory properties, including their drug likeness and druggability, as analyzed with the SwissADME and ADMETlab online tools. In the future, some sesquiterpenoids might serve as therapeutic agents to treat inflammation-associated diseases.

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Section: Introductionmentioning

confidence: 99%

Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review

Chen,

Feng,

Petrović

et al. 2023

Acta Materia Medica

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A critical review on Pulicaria species occurring in Qatar: traditional uses, phytochemistry and biological activities

Kasote,

Nawaz,

Usman

et al. 2024

Phytochem Rev

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In Qatar, three main species of Pulicaria (from Asteraceae) such as Pulicaria undulata (L.) C.A.Mey, Pulicaria gnaphalodes (Vent.) Boiss. and Pulicaria sicula (L.) Moris are reported. Traditionally, these species have almost the same ethnomedical uses, including their use as herbal tea. This could be because of morphological similarities among some of these species, which also results in taxonomic ambiguity. Altogether, this indicates that these species need to be reviewed comparatively, to understand the phytochemical uniqueness and therapeutic significance of each species individually, including species differentiation at the subspecies level. Hence, this review aims to comparatively review the available literature about traditional uses, phytochemistry, and bio-activities of these species. Being aromatic plants, the chemical composition of essential oils of these species has been extensively studied and reported over 300 volatile organic compounds. Among these, oxygenated monoterpenes and sesquiterpenes are dominant. The diverse and distinguishable composition of essential oils can differentiate P. undulata and Pulicaria crispa (Forssk.) Oliv. (Synonyme: Pulicaria undulata subsp. undulata). Likewise, flavonoids and sesquiterpenes are the most reported classes of compounds in non-essential oil fractions. Various biological and pharmacological activities are reported to the essential oils, crude extracts, and their fractions, or isolated compounds of these species. Among these, antimicrobial, anticancer, and anti-oxidant activities were mostly investigated, mainly under in vitro conditions. Several distinguishable compounds are listed for each species that can potentially be used as chemical markers while characterizing these species. Most of the traditional claims of these species are validated in recent scientific studies. However, further detailed in vivo clinical interventions are needed for their potential use as therapeutic agents.

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Analgesic, antipyretic, anti-inflammatory, and hepatoprotective activities of Pulicaria crispa (Forssk.) Oliv. (Asteraceae)

Cited by 2 publications

References 42 publications

Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review

Sesquiterpenoids from the sunflower family as potential anti-inflammatory candidates: a review

A critical review on Pulicaria species occurring in Qatar: traditional uses, phytochemistry and biological activities

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