Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex

Abstract

The main purpose of this work was to compare the effects of the four preparation methods on the TFLX/HP-β-CD inclusion complex. The effects of different preparation methods on the inclusion complex were investigated by SEM, DSC, PXRD, FT-IR and 1 H NMR. All the characterization information indicated that the four preparation methods could cause interaction between TFLX and HP-β-CD, but the inclusion complex prepared by solvent evaporation has more reaction sites. Phase solubility experiments demonstrated that the inclusion reaction was spontaneous. In vitro dissolution experiments showed that the dissolution of the inclusion complex in water was: solvent evaporation method (64.39%) > grinding method (42.37%) > ultrasonic method (40.00%) > freezing method (36.08%), and all higher than pure TFLX and physical mixture. These results suggest that the solvent evaporation is the most suitable method for preparing TFLX/HP-β-CD inclusion complexes.

A Review on Cyclodextrins/Estrogens Inclusion Complexes

“…It should also be noted that some of the steroid estrogens exhibit stereoisomerism and the enantiomers usually significantly differ in their biological activities, such as in the case of 17-α and 17-β estradiol. It is well known that the method of complex preparation may have a significant influence on the form of the complex received [21][22][23]. This is why the CD complexes are usually deeply characterized by various analytical methods, both in solid state and solution [24][25][26].…”

“…Consequently, each paragraph of the main part of this review is constructed in a similar way, presenting detailed information on the methods of preparation and physiochemical analysis of CD-based complexes of a particular estrogen molecule. It is well known that the method of complex preparation may have a significant influence on the form of the complex received [21][22][23]. This is why the CD complexes are usually deeply characterized by various analytical methods, both in solid state and solution [24][25][26].…”

17-β-Estradiol—β-Cyclodextrin Complex as Solid: Synthesis, Structural and Physicochemical Characterization

“…Multiple preparation methods for CD inclusion complexes are being exploited, such as the solvent evaporation method, grinding method, ultrasonic method, and freeze-drying method. It has been shown in many examples that the method of complex preparation may have a major impact on the obtained form of the final product [12][13][14].…”