New flavonoid with antidiabetic and antioxidant potential from Tetrastigma angustifolia (Roxb.) Deb leaves

Junejo, Julfikar Ali; Zaman, Kamaruz; Ali, Mohammed; Rudrapal, Mithun

doi:10.1590/s2175-97902019000418806

Cited by 9 publications

(10 citation statements)

References 52 publications

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“…Abnormality in glucose metabolism leads to hyperglycemia and consequently diabetes mellitus (type-1 and type-2). Apart from co-morbidities like heart disease or stroke, chronic complications may develop in diabetes such as diabetic retinopathy affecting eyes cause blindness, nephropathy altered renal functions, and neuropathy causing nerve damage and numbness/paralysis ( Rizvi and Zaid, 2001 ; Rizvi and Zaid 2005 ; Junejo et al, 2017 ; Junejo et al, 2018 ; Junejo et al, 2020a ; Junejo et al, 2020b ; Hussain et al, 2021 ; Junejo et al, 2021 ). Apigenin derivative possesses strong antidiabetic activity extending protection against the variations throughout OS in diabetes ( Junejo et al, 2021 ).…”

Section: Polyphenols and Their Protective Effects Against Human Diseasesmentioning

confidence: 99%

Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

Rudrapal¹,

Khairnar²,

Khan

et al. 2022

Front. Pharmacol.

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246

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Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, and beverages like fruit juices, tea, coffee and wine. In recent years, dietary polyphenols have gained significant interest among researchers due to their potential chemopreventive/protective functions in the maintenance of human health and diseases. It is believed that dietary polyphenols/flavonoids exert powerful antioxidant action for protection against reactive oxygen species (ROS)/cellular oxidative stress (OS) towards the prevention of OS-related pathological conditions or diseases. Pre-clinical and clinical evidence strongly suggest that long term consumption of diets rich in polyphenols offer protection against the development of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases (CVDs), cancer, diabetes, inflammatory disorders and infectious illness. Increased intake of foods containing polyphenols (for example, quercetin, epigallocatechin-3-gallate, resveratrol, cyanidin etc.) has been claimed to reduce the extent of a majority of chronic oxidative cellular damage, DNA damage, tissue inflammations, viral/bacterial infections, and neurodegenerative diseases. It has been suggested that the antioxidant activity of dietary polyphenols plays a pivotal role in the prevention of OS-induced human diseases. In this narrative review, the biological/pharmacological significance of dietary polyphenols in the prevention of and/or protection against OS-induced major human diseases such as cancers, neurodegenerative diseases, CVDs, diabetes mellitus, cancer, inflammatory disorders and infectious diseases have been delineated. This review specifically focuses a current understanding on the dietary sources of polyphenols and their protective effects including mechanisms of action against various major human diseases.

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Section: Polyphenols and Their Protective Effects Against Human Diseasesmentioning

confidence: 99%

Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

Rudrapal¹,

Khairnar²,

Khan

et al. 2022

Front. Pharmacol.

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246

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“…On the same day, immediately after euthanasia, pancreases were collected for the histopathological studyfrom the animals. [27][28][29][30]…”

Section: Antidiabetic Activity Evaluationmentioning

confidence: 99%

“…The tissues were processed according to standard procedure and later stained with hematoxylin and eosin before observation under the microscope. [27][28][29][30][31][32] Microscopical photographs of the pancreases tissues of different groups were taken by Leica microscope (DM1000) at 40X magnification (Figure 2).…”

Section: Histology Studymentioning

confidence: 99%

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model

Singh,

Chetia,

Gogoi

et al. 2023

Chemistry & Biodiversity

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Allium hookeri (F: Liliaceae), an indigenous plant of Manipur, India, is traditionally used to treat various diseases and disorders like diabetes, hypertension, and stomach ache. In our previous study, the methanol extract of the plant showed significant antidiabetic potential in rats. In the present study, we evaluated the antidiabetic potential of a flavonoid compound named MEA isolated from the methanolic leaf extract of A. Hookeri in rats. Additionally, we assessed the compound's mode of action through the molecular docking study. The MEA reduced the blood glucose level from 317±12.8 to 99.4±6.67 mg/dl after 21 days of treatment. Besides, MEA also restored the body weights and other biochemical parameters including lipid profile significantly compared to the diabetic group (p<0.001). The histoarchitecture of the pancreatic tissues of the MEA treated group was also improved compared to the diabetic group. In the docking study, the compound showed good binding affinity in the active binding site of the two structures of pancreatic beta‐cell SUR1 (Sulfonylurea Receptor 1) subunit with CDocker energy −31.556 kcal/mol and −39.703 kcal/mol, respectively. The compound MEA was found to be drug‐like with non‐carcinogenic, non‐mutagenic and non‐irritant properties. These findings indicate the antidiabetic potential of MEA, which might act by modulating the pancreatic beta‐cell SUR1 subunit present in the KATP channel. Hence, the MEA would be a promising lead molecule to develop new antidiabetic drug candidates of the future.

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“…The MECD was subjected to column chromatographic separation using silica gel (packed column, 100-200 mesh) and a glass column (6.0 × 3 inch dimension) [6] for the isolation of bioactive phytoconstituents in pure form. The elution was carried out by gradient separation technique using the solvent system of n-hexane/ethyl acetate.…”

Section: Isolation Of Phytocompoundsmentioning

confidence: 99%

“…Betulin, lupeol-3-rhamnoside, β-sitosterol, taxifolin-3-5dirhamnoside, hesperitin-7-rhamnoside, rutin, chlorogenic acid and caffeic acid have been reported from seeds of C. dichotoma [2][3][4][5]. Flavonoids, the most important class of plant polyphenolics possessing diverse range of biological/pharmacological potential [6][7][8], are attributed to be the most dominant phytochemical components in various plant parts of C. dichotoma. In this work, the isolation and identification of bioactive flavonoids from the methanolic bark extract of C. dichotoma Forst was carried out.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Antidiabetic Flavonoids from the Stem Bark of Cordia dichotoma Forst.: Identification, Docking and ADMET Studies

Hussain

Kakoti

Rudrapal³

et al. 2021

Molbank

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Cordia dichotoma Forst. (F. Boraginaceae) has been traditionally used for the management of a variety of human ailments. In our earlier work, the antidiabetic activity of methanolic bark extract of C. dichotoma (MECD) has been reported. In this paper, two flavonoid molecules were isolated (by column chromatography) and identified (by IR, NMR and mass spectroscopy/spectrometry) from the MECD with an aim to investigate their antidiabetic effectiveness. Molecular docking and ADMET studies were carried out using AutoDock Vina software and Swiss ADME online tool, respectively. The isolated flavonoids were identified as 3,5,7,3′,4′-tetrahydroxy-4-methoxyflavone-3-O-L-rhamnopyranoside and 5,7,3′-trihydroxy-4-methoxyflavone-7-O-L-rhamnopyranoside (quercitrin). Docking and ADMET studies revealed the promising binding affinity of flavonoid molecules for human lysosomal α-glucosidase and human pancreatic α-amylase with acceptable ADMET properties. Based on computational studies, our study reports the antidiabetic potential of the isolated flavonoids with predictive pharmacokinetics profile.

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New flavonoid with antidiabetic and antioxidant potential from Tetrastigma angustifolia (Roxb.) Deb leaves

Cited by 9 publications

References 52 publications

Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

In Vivo and in Silico Based Evaluation of Antidiabetic Potential of an Isolated Flavonoid from Allium hookeri in Type 2 Diabetic Rat Model

Bioactive Antidiabetic Flavonoids from the Stem Bark of Cordia dichotoma Forst.: Identification, Docking and ADMET Studies

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