Effects of gallic acid and physical exercise on passive avoidance memory in male rat

Salehi, Azadeh; Rabiei, Zahra; Setorki, Mahbubeh

doi:10.1590/s2175-97902019000218261

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…In addition, the present study found that mice treated with 50 mg/kg ( P =0.0045 and 0.0007) and 100 mg/kg ( P =0.0012 and 0.0002) showed significantly reduced MDA levels when compared to sham-veh and PD-veh, respectively. These results indicated the beneficial effect of gallic acid, especially against lipid peroxidation and previous report also indicated the ameliorative effect of gallic acid on MDA in mouse brain as well [ 35 ]. The potential anti-PD mechanism of gallic acid acquired from previous in vivo research also indicated the antioxidant features of gallic acid.…”

Section: Resultssupporting

confidence: 74%

Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration

Thong-asa,

Wassana,

Sukkasem

et al. 2024

Exp. Anim.

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We investigated the effect of gallic acid against neurodegenerative pathophysiology relevant to PD in mice with rotenone-induced toxicity. Forty male ICR mice were randomly divided into four groups: sham-veh, PD-veh (received subcutaneous injection with 2.5 mg/kg/48 hours of rotenone); PD-Gal50; and PD-Gal100 (the latter two groups received subcutaneous injection with 2.5 mg/kg/48 hours of rotenone and oral gavage with gallic acid 50 and 100 mg/kg/48 hours, respectively). All treatments continued for 5 weeks with motor ability assessments once per week using hanging and rotarod tests. Brain tissue evaluation of oxidative status, together with striatal and substantia nigra par compacta (SNc) histological and immunohistological assessments were performed. The results indicate that rotenone significantly induced muscle weakness and motor coordination deficit from the first week of rotenone injection, and a significant increase in neuronal degeneration was presented in both the striatum and SNc. Decreased tyrosine hydroxylase and increment of glia fibrillary acidic protein expression in SNc were depicted. The deteriorating effects of rotenone were ameliorated by gallic acid treatment, especially 100 mg/kg dose. Rotenone did not induce a significant change of lipid peroxidation indicated, but gallic acid exhibited a significant inhibitory effect on the lipid peroxidation increment. Rotenone showed a significant reduction of superoxide dismutase activity, and neither 50 nor 100 mg/kg of gallic acid could alleviate this enzyme activity. In conclusion, gallic acid ameliorated motor deficits and preserving SNc neurons which led to maintaining of the dopaminergic source, including a nurturing effect on supporting astrocytes in mice with rotenone-induced neurodegeneration.

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Section: Resultssupporting

confidence: 74%

Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration

Thong-asa,

Wassana,

Sukkasem

et al. 2024

Exp. Anim.

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“…1500 emery paper, followed by an ultrasonic coat with distilled water and ethanol for adequate cleaning. The GCE electrode was then coated by immersing it in the hybrid solution (0.1 mg/mL) in ethanol and subsequently air-dried (Scheme 2) [Salehi et al 2019;Sarkaki et al 2015;Sharifi et al 2020].…”

Section: Morphological Analysismentioning

confidence: 99%

Dual functional In2O3-PANI-PEDOT Hybrid for Sensing Gallic Acid and Photocatalytic Degradation of Methylene Blue

Settu,

Govindhan,

Thirugnanam

et al. 2024

Preprint

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In this study, we have investigated the electrocatalytic properties of a nanohybrid composed of In2O3 nanoparticles and a copolymer of PEDOT-PANI. In2O3 nanoparticles, synthesized at 20 and 50 nm sizes, were combined with PANI-PEDOT to form a nanocomposite. The electrocatalytic activity of the nanohybrid was evaluated through catalytic studies using gallic acid (GA) as a model analyte and employing differential pulse voltammetry (DPV). The modified glassy carbon electrode (GCE) exhibited linear responses towards GA in the concentration range of 0.2×10−8 to 1.2×10−9 M, with a sensitivity of 3.102 µA/µM cm−2. The detection limit (DL) and quantification limit (QL) were determined to be 1.108×10-9 and 2.1810×10-9 M µA-1, respectively, indicating the suitability of the nanohybrid for electrochemical sensing applications. Additionally, the nanocomposite demonstrated promising photocatalytic activity, with a maximum efficiency of 98.9% towards methylene blue (MB) degradation within 60 minutes. The interference of reactive hydroxide ions (OHo) formed during the degradation process was observed but did not significantly affect the overall performance. This study highlights the potential of In2O3-PANI-PEDOT nanocomposite for use in electrochemical sensing and photocatalytic applications, with opportunities for further optimization and development of hybrids.

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Effects of gallic acid and physical exercise on passive avoidance memory in male rat

Cited by 2 publications

References 23 publications

Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration

Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration

Dual functional In2O3-PANI-PEDOT Hybrid for Sensing Gallic Acid and Photocatalytic Degradation of Methylene Blue

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