Influence of sonication and in vitro evaluation of nifedipine self-nanoemulsifying drug delivery system

Eid, Ahmad; Elmarzugi, Nagib Ali; Jaradat, Nidal

doi:10.1590/s2175-97902019000217497

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…The results of globule size analysis using a particle size analyzer showed that CLO-SNEDDS (F2D) was able to form a nanoemulsion system after dilution with a globule size of 125 nm and a PDI value of 0.515. These results followed the globule size requirements for SNEDDS (20-200 nm) and PDI of <0.7 30 .…”

Section: Resultssupporting

confidence: 71%

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Cod Liver Oil

2021

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Cod liver oil (CLO) has long been used as medicine or as a functional food. The CLO is a potential source of vitamin D, vitamin A, and omega fatty acids (eicosapentaenoic acid/EPA and docosahexaenoic acid/DHA). Self-nanoemulsifying drug delivery system (SNEDDS) can enhance dissolution, absorption, and bioavailability of hydrophilic and lipophilic substances for oral administration. The objective of this study was to develop a SNEDDS of CLO with good physical characteristics and stability. The optimization formula was carried out using various ratios of oil, surfactant, and cosurfactant. The physical properties of SNEDDS were determined by transmittance percentage, dispersibility, robustness, thermodynamics stability (heating-cooling cycle, centrifugation, and freeze-thaw cycle), and globule size distribution. The optimum formula of CLO-SNEDDS was obtained at a ratio of surfactant and cosurfactant 2 : 1 and a comparison of oil and surfactant mixtures 1 : 6. The CLO-SNEDDS meets the requirement of percent transmittance (97.90±0.85), dispersibility (grade A), and stability based on robustness and thermodynamic stability tests. Diluted SNEDDS has an average globule size of 125 nm with a polydispersity index (PDI) of 0.515. CLO-SNEDDS preparation has good physical characteristics and stability.

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Section: Resultssupporting

confidence: 71%

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Cod Liver Oil

2021

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“…These results demonstrate that the higher long-term stability of honokiol PLGA − PEG nanoparticles when stored at 4 °C allows them to maintain good drug content in the nanocarrier. In addition, some studies recommend storing drug-carrying nanoparticles at 4 °C [38,41].…”

Section: Encapsulation Efficiency and Loading Capacity Of Honokiol Pl...mentioning

confidence: 99%

Stability of soluble honokiol loaded PLGA-PEG nanoparticles under normal and accelerated-aging conditions

Minh¹,

Manh²,

Van³

et al. 2023

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Honokiol, a plant bioactive compound, is derived from the Magnolia genus and has several pharmacological advantages including anti-inflammatory, antiviral, neuromodulatory and anti-tumour activities. However, honokiol’s pharmaceutical utility is constrained by its poor solubility in water. Nanotechnology has been widely used to address this issue to make anticancer medications more effective by increasing their water solubility. Furthermore, the stability of the nanoparticles is one of the most important factors affecting the safety and efficacy of the drug. In this study, honokiol-loaded PLGA − PEG nanoparticles were synthesised and the stability of this nanosystem was evaluated in two conditions that are normal condition and accelerated-aging condition. The parameters used to evaluate the stability of the nanocarrier system include particle size, polydispersity index, zeta potential, morphology, encapsulation efficiency, and loading capacity. All of the samples were stored at three temperatures of 4 °C, 27 °C and 40 °C, and assessed at four times of 0 month, 1 month, 2 months, and 3 months. The physicochemical parameters of nanoparticles after three months of storage showed greater stability at 4 °C compared to 27 °C and 40 °C. There were no significant differences in the parameters of samples stored in three months at 4 °C, meanwhile, the parameters of those stored at 27 °C and 40 °C fluctuated considerably. Therefore, the results show that storing samples at 4 °C allows maintaining the stability of the nanosystem for a long time.

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“…Crystal engineering is a method to design a crystalline molecular solids with the aim of impacting material properties [10]. In recent years, the advances in crystal engineering have emerged in the research for design of pharmaceutical cocrystals which consists the API and another compound (called co-former) at a given stoichiometric ratio [11].…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Dissolution Rate and Bioavailability of Nifedipine by Chitosan Based Cocrystallization Technique

Reetu

Yadav²,

Singh³

et al. 2021

JPRI

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The objective of present study was to enhance solubility and dissolution behaviour of nifedipine by using cocrystallization method. A significant increase in solubility and dissolution rate of nifedipine has been demonstrated by solvent change method using chitosan. In this method, chitosan was precipitated on nifedipine crystals using sodium citrate as a salting out agent. An accurately weighed chitosan was dissolved in 1% acetic acid and drug was added in the chitosan solution. This resulting solution was added drop wise into 1% sodium citrate solution with continuous stirring. Sodium citrate precipitate polymer on drug crystals. FTIR, DSC, XRD, SEM, In-vitro dissolution studies, were studied for characterization of prepared cocrystals. Stability studies showed a good stability character of prepared cocrystals. Design Expert® software version 10.0 was used to develop polynomial models which were analysed to delineate the main effects for each CQA (critical quality attributes) through Box-Bhenken design expert. Pharmacokinetic study clearly showed the enhancement of dissolution rate of cocrystals. The above investigation concluded that the significant dose reduction is possible for nifedipine with cocrystal formulation which leads to improve patient compliance.

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Influence of sonication and in vitro evaluation of nifedipine self-nanoemulsifying drug delivery system

Cited by 6 publications

References 42 publications

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Cod Liver Oil

Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Cod Liver Oil

Stability of soluble honokiol loaded PLGA-PEG nanoparticles under normal and accelerated-aging conditions

Enhancement of Dissolution Rate and Bioavailability of Nifedipine by Chitosan Based Cocrystallization Technique

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