To be or not to be a carcinogen; delving into the glyphosate classification controversy

Paumgartten, Francisco José Roma

doi:10.1590/s2175-97902019000118217

Cited by 4 publications

(1 citation statement)

References 64 publications

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“…However, the absence of its genotoxic activity is also reported [14,15]. Several studies suggest that it is carcinogenic [11,16,17] and contributes to the development of non-Hodgkin lymphoma in humans [18], however, there is controversy among the IARC, regulatory authorities, and scientists regarding its carcinogenic potential [3,16,18,19]. Some research suggests that the adjuvants present in GBH are responsible for the genotoxic activity and not G [1,20,21]; however, this is also highly controversial because other studies report the opposite [14,15,[21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Genetic Damage Induced via Glyphosate and Three Commercial Formulations with Adjuvants in Human Blood Cells

Alvarez-Moya

Reynoso-Silva

2023

IJMS

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There is considerable controversy regarding the genotoxicity of glyphosate (N-(phosphonomethyl) glycine). It has been suggested that the genotoxicity of this herbicide is increased by the adjuvants added to commercial formulations based on glyphosate. The effect of various concentrations of glyphosate and three commercial glyphosate-based herbicides (GBH) on human lymphocytes was evaluated. Human blood cells were exposed to glyphosates of 0.1, 1, 10 and 50 mM as well as to equivalent concentrations of glyphosate on commercial formulations. Genetic damage (p < 0.05) was observed in all concentrations with glyphosate and with FAENA and TACKLE formulations. These two commercial formulations showed genotoxicity that was concentration-dependent but in a higher proportion compared to pure glyphosate only. Higher glyphosate concentrations increased the frequency and range of tail lengths of some migration groups, and the same was observed for FAENA and TACKLE, while in CENTELLA the migration range decreased but the frequency of migration groups increased. We show that pure glyphosate and commercial GBH (FAENA, TACKLE and CENTELLA) gave signals of genotoxicity in human blood samples in the comet assay. The genotoxicity increased in the formulations, indicating genotoxic activity also in the added adjuvants present in these products. The use of the MG parameter allowed us to detect a certain type of genetic damage associated with different formulations.

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