Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides

Upadhyay, Jyoti; Bisht, Satpal Singh; Rana, Amita; Durgapal, Sumit; Juyal, Vijay

doi:10.1590/s2175-97902019000118194

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…It further may induce developmental and behavioral abnormalities, hematological malignancies, histopathological alterations, oxidative stress, genotoxicity and immunotoxicity as evidenced by animal modeling (Ubaidur Rahman et al, 2021). According to recent studies conducted by Upadhyay et al (2019), acephate exposure caused changes in biomarker responses like total protein and total cholesterol in female wistar rats. Liver and kidney collectively play an important role in metabolization process by transformation of thiono organophosphates accompanied by elimination process and act as main sites where maximum effects of pesticide by generation of oxidative stress can be seen.…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Acephate to Liver and Kidney of Female Wistar Rats

Jain

Vashishat

2022

ije

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Acephate is a broad spectrum insecticide used against pests of vegetables, cotton and ornamental plants. In the present study, acephate was orally administered to female wistar rats to examine its toxic effects, if any, at dose level of 1/50th, 1/25th and 1/10th of LD50 value along with a control group for 45 days. Results revealed a remarkable decrease in the feed intake of 1/10th acephate treated rats during 5th and 6th week of treatment. The net body weights and liver weight decreased non-significantly to a small extent over 45 days of treatment. The weight of kidney and content of total soluble protein decreased significantly in a dose dependent manner in treated rats. The significant alterations in the activity of antioxidative enzymes i.e. glutathione peroxidase, glutathione-S-transferase, glutathione reductase, superoxide dismutase, catalase and lipid peroxidation levels were observed. The appearance of comet in 1/10th dosed rats indicated DNA damage. Further, no formation of concentric rings in treated rats indicated the absence or low concentration of antibodies in the serum.

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Section: Resultsmentioning

confidence: 99%

Toxicity of Acephate to Liver and Kidney of Female Wistar Rats

Jain

Vashishat

2022

ije

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“…However, the GLY supplied was in a mixture with seven other pesticides, and its specific effects were not studied. Upadhyay et al (2019) found higher levels of blood lipids (cholesterol and triglycerides) and transaminases, which are markers of liver damage, pregnant rats exposed to a GLY-based formula, and De Souza et al ( 2017) reported endocrine disrupting activity of GLY when observing lower levels of thyroid-stimulating hormone in rats after intervention with the GLY-based herbicide (Upadhyay et al 2019).…”

Section: Other Reproductive Effects Evaluated In Animal Modelsmentioning

confidence: 99%

Effects of Glyphosate Exposure on Reproductive Health: A Systematic Review of Human, Animal and In-Vitro Studies

2021

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Glyphosate is the most widely used herbicide in the world. We examined whether and how human populations exposed to glyphosate at any age are at risk of developing reproductive health effects. Protocol was developed following the recommendations of the PRISMA guidelines. Original research published in indexed journals was included with direct and indirect exposure to glyphosate, from any country/region, without publication year restriction, in English or Spanish. We included observational studies in humans, as well as experiments in vitro or in animal models. Studies were searched in four databases. The scoring assignments were based on the guidelines for conducting systematic reviews in the development of toxicity factors. The findings on the agent and exposure assessment were retrieved and summarized in a narrative synthesis. After eliminating duplicates among the identified articles and reviewing the inclusion and exclusion criteria, 80 were included in the narrative synthesis, i.e., 20 human studies, 44 animal studies, and 16 using in vitro models. This review shows strong experimental evidence, in animal models and in vitro studies, of glyphosate toxicity in reproduction and development as well as related metabolic and disease consequences. Several of these studies show significant health consequences for mothers, fetuses, and offspring, even several generations after exposure. Human studies, in contrast, are scarce and controversial. Nevertheless, we believe that the evidence is sufficient to, under the precautionary principle, define policies to prevent exposure of women, their partners, and their children to glyphosate.

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Adiantum capillus-veneris Linn protects female reproductive system against carbendazim toxicity in rats: immunohistochemical, histopathological, and pathophysiological studies

Madboli

Seif

2021

Environ Sci Pollut Res

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Biomarker responses (serum biochemistry) in pregnant female wistar rats and histopathology of their neonates exposed prenatally to pesticides

Cited by 3 publications

References 20 publications

Toxicity of Acephate to Liver and Kidney of Female Wistar Rats

Toxicity of Acephate to Liver and Kidney of Female Wistar Rats

Effects of Glyphosate Exposure on Reproductive Health: A Systematic Review of Human, Animal and In-Vitro Studies

Adiantum capillus-veneris Linn protects female reproductive system against carbendazim toxicity in rats: immunohistochemical, histopathological, and pathophysiological studies

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