Association of hypertension and dyslipidaemia with increasing obesity in patients with Type 2 Diabetes Mellitus

Saleem, Zikria; Saeed, Hamid; Khan, Zohaib Abbas; Khan, Muhammad Imran; Hashmi, Furqan Khurshid; Islam, Muhammad; Bashir, Afzaal; Sadeeqa, Saleha

doi:10.1590/s2175-97902019000118136

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…In this study, findings showed that the mean body mass index (BMI) in the patients was 29.26 ± 2.49 kg/m 2 and indicates overweight, which was consistent with the studied by Wei et al ( 18), Zhou et al (19) and Saleem et al (20). Obesity is very common in type 2 diabetes (≥80% of patients are obese), also it is thought to be part of the pathogenic process.…”

Section: Discussionsupporting

confidence: 91%

Lack of association between diabetic nephropathy and human leukocyte antigen type 2 (HLA II-DQ1) in patients with type 2 diabetes mellitus in west of Iran

et al. 2020

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Introduction: Diabetic nephropathy (diabetic kidney disease) is one of the microvascular complications of diabetes mellitus. The human leukocyte antigen (HLA) is a group of genes that is related to autoimmune diseases, infections and inflammation. Studies regarding the association of type 2diabetes and HLA-II are negligible. Objectives: The aim of this study is to determinate association between diabetic nephropathy and HLA II-DQ1 in diabetes type 2 patients. Patients and Methods: In this study, 120 diabetes type 2 patients were divided into two groups of diabetic nephropathy (case group) and without diabetic nephropathy (control group). Blood samples were taken and DNA was isolated. Asymmetric polymerase chain reaction (PCR) was used to amplify the HLA II-DQ1 exon 2 and exon 3. PCR products were hybridized and labeled with probes on the chip. Determination of HLAII-DQ1 gene typing was conducted by scanning hybrid products and analyzed with PerkinElmer ScanArray software. Results: The results of chi-square test showed no significant difference between expression levels of HLA in the two groups (P<0.05). Conclusion: There was no significant difference between expression levels of HLA in two groups of patients. Various factors such as demographic characteristics, lifestyle, geographic region, and race are the factors influencing the relationship between diabetic nephropathy and DQ1-HLA II. Since this study is conducted in one region and one race and with limited population, it is suggested that future studies should be considered and the association between the mentioned variables with HLA should be considered.

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Section: Discussionsupporting

confidence: 91%

Lack of association between diabetic nephropathy and human leukocyte antigen type 2 (HLA II-DQ1) in patients with type 2 diabetes mellitus in west of Iran

et al. 2020

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“…According to a cross-sectional study of diabetic adults 28-75 years old in the Diabetes Clinic of Golestan Hospital, Ahvaz, Khuzestan Province, Iran, there was a strong association between WC and hypertension prevalence in diabetic patients [47]. Saleem et al [48] suggested that hypertension is closely related to obesity in individuals with diabetes and that hypertension is more likely to be present as weight and obesity increase in individuals with diabetes in Lahore, Pakistan. Our results are in agreement with the results of previous studies [11,46,47,[68][69][70] related to HDC, indicating that WHtR and WC were better indicators than other anthropometric indices in men and women and that BMI was an insufficient predictor of HDC.…”

Section: Plos Onementioning

confidence: 99%

“…However, WC does not consider height, and WHtR, which reflects the ratio of WC to height, has recently been reported as a risk factor for diabetes [37][38][39][40][41][42][43] and hypertension [30,36,44,45]. These obesity-related indicators are also known as risk factors for HDC [46][47][48]. However, these obesityrelated indicators cannot distinguish between body fat mass and muscle mass.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study

Hee

Lee

2022

PLoS ONE

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Background Hypertension and diabetes are risk factors for severe cardiovascular disease and are prevalent comorbidities. No studies have examined the associations of various risk factors related to anthropometry, bone mineral density and body composition of specific body regions with hypertension and diabetes comorbidity (HDC). This study explored the association between HDC and various risk factors related to specific body regions. Method A total of 7,978 subjects (3,451 men and 4,527 women) aged ≥ 50 years were included in the analysis. A binary logistic regression analysis based on complex sample data analysis was conducted to examine associations between the normal and diabetes groups, between the normal and hypertension groups, and between the normal and HDC groups. Results Among Korean adults aged ≥ 50 years, 11.27% of men and 10.05% of women had both diabetes and hypertension. The HDC prevalence was higher in men than in women. In men, waist-to-height ratio (WHtR, adjusted OR = 1.63 [1.22–2.18], adjusted p<0.001) exhibited a more significant association with HDC than other indices, left leg fat mass (adjusted OR = 0.61 [0.45–0.81], adjusted p = 0.0009) and right leg fat mass (adjusted OR = 0.60 [0.45–0.81], adjusted p = 0.0007) displayed strong negative associations with diabetes, and left leg lean mass (adjusted OR = 0.77 [0.67–0.89], adjusted p = 0.0002) and trunk fat mass (adjusted OR = 1.28 [1.07–1.52], adjusted p = 0.0062) were significantly associated with hypertension. In women, left leg fat mass (adjusted OR = 0.29 [0.22–0.39], adjusted p<0.0001) and right leg fat mass (adjusted OR = 0.32 [0.23–0.45], adjusted p<0.0001) exhibited strong negative associations with HDC, waist circumference (WC) (adjusted OR = 2.15 [1.40–3.30], adjusted p = 0.0005) showed a stronger association with diabetes than did other indices, and WC (adjusted OR = 1.39 [1.11–1.74], adjusted p = 0.0040) and WHtR (adjusted OR = 1.39 [1.09–1.76], adjusted p = 0.0075) were significantly associated with hypertension. Discussion HDC was more strongly associated with fat and lean mass than diabetes and hypertension. The association between HDC and body fat variables was more robust in women than in men.

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Predictors of HbA1c treatment response to add-on medication following metformin monotherapy: a population-based cohort study

Tan,

Hsu,

Lee

et al. 2023

Sci Rep

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Evidence on the influence of patient characteristics on HbA1c treatment response for add-on medications in patients with type 2 diabetes (T2D) is unclear. This study aims to investigate the predictors of HbA1c treatment response for three add-on medications (sulfonylureas (SU), dipeptidyl peptidase-4 (DPP-4) and sodium–glucose cotransporter-2 (SGLT-2) inhibitor) in metformin monotherapy treated patients with T2D. This retrospective cohort study was conducted using the electronic health record data from six primary care clinics in Singapore. A total of 9748 adult patients with T2D on metformin monotherapy receiving SU, DPP-4 or SGLT-2 add-on were 1:1 propensity score matched to patients receiving other add-on medications. Patient demographics, laboratory results, diabetes related complications, comedications, and treatment response at two endpoints (HbA1c reduction ≥ 1% at 6th month, HbA1c goal attainment < 7% at 12th month) were examined. Multiple logistic regression analyses were used to identify patient characteristics associated with the treatment responses. After matching, there were 1073, 517, and 290 paired cohorts of SU, DPP-4 and SGLT-2 respectively. Besides baseline HbA1c, patients with longer hypertension disease duration and higher cholesterol HDL were associated with better treatment response to SU medication add-on. Lower estimated glomerular filtration rate (eGFR), and angiotensin-II receptor medications were associated with better treatment response to DPP-4 add-on. Lower cholesterol HDL, higher creatinine serum, absence of renal complications and beta-blockers medications were associated with better treatment response to SGLT-2 add-on. The cholesterol HDL, creatinine serum, eGFR, hypertension disease duration, angiotensin-II receptors and beta-blockers class of medications can influence the HbA1c treatment response for SU, DPP-4 and SGLT-2 add-on medications. Knowing the patients’ characteristics that influence treatment response can assist in guiding clinical decisions when selecting the appropriate add-on medication, ultimately helping to prevent the development of diabetes-related complications.

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Association of hypertension and dyslipidaemia with increasing obesity in patients with Type 2 Diabetes Mellitus

Cited by 4 publications

References 24 publications

Lack of association between diabetic nephropathy and human leukocyte antigen type 2 (HLA II-DQ1) in patients with type 2 diabetes mellitus in west of Iran

Lack of association between diabetic nephropathy and human leukocyte antigen type 2 (HLA II-DQ1) in patients with type 2 diabetes mellitus in west of Iran

Risk factors for hypertension and diabetes comorbidity in a Korean population: A cross-sectional study

Predictors of HbA1c treatment response to add-on medication following metformin monotherapy: a population-based cohort study

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