Antifungal effect of sesame medicinal herb on Candida Species: original study and mini-review

Abstract

The aim of this study was to evaluate the antifungal susceptibility patterns of three antifungals, methanolic extracts and N-hexane oil of sesame seeds on C. albicans and C. glabrata, isolated from oral cavity of liver transplant recipients. The results were compared with other reports to develop a mini review as well. Candida species were isolated from liver transplant recipients. To evaluate the antifungal activity of sesame seed oil and methanolic extract, fluconazole, caspofungin and nystatin, the corresponding minimum inhibitory concentrations were determined by CLSI M27-A3 standard method. Minimum fungicidal concentration was also evaluated. The most prevalent species was C. albicans, followed by C. glabrata. Findings indicated sensitivity to antifungal agents and resistance to methanolic extract and N-hexane oil for all C. albicans and C. glabrata isolates. The rate of Candida colonization in the oral cavity of liver transplant recipients was high. Our results revealed that the methanolic and N-hexan extracts of sesame seeds are not effective on C. albicans and C. glabrata species, isolated from the patients. The sesame seed oil pulling and mouthwash cannot effectively cleanse and remove the Candida species in the mouth. Investigation of other medicinal plants or other parts of sesame like leaves and roots are suggested.

Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis

“…It means the SO-to-Compritol ratio and Labrasol concentration of the NLCs could restrict fungal growth in the selected medium with their increased concentrations. The reasons for this were the antifungal activity of SO (Lavaee et al., 2019 ) and the emulsification property of Labrasol, which increased the antifungal activity via the accelerating permeability (Alkhalidi et al., 2021 ) of MZ-SO-loaded NLCs. Additionally, the contour plot and 3D surface plot ( Figure 4 ) exhibited the impacts of independent factors on the inhibition zone of various fabricated NLCs.…”

Antibiofilm Potential of Medicinal Plants against Candida spp. Oral Biofilms: A Review

“…A variety of local and systemic predisposing factors can lead to the transition from commensal to pathogenic Candida , namely the use of dentures, corticosteroid inhalers, and xerostomia, and systemic factors such as immunosuppressive states, HIV infection, malnutrition, diabetes, systemic chemotherapy, and radiotherapy, among others [ 63 ]. Therefore, about 65% of oral candidiasis are identified in the elderly, usually due to the use of dentures, and other pathologies associated with this age group, and about 16.7% in patients with hematological disorders [ 64 ]. Other factors, such as the diversity of microorganisms, the presence of saliva, vascularization, contamination by food residues, and trauma resulting from lack of hygiene, increase the inflammatory process, healing time, and patient discomfort [ 65 , 66 ].…”

From Treatise to Test: Evaluating Traditional Remedies for Anti-Biofilm Potential

“…This is important given that plant-based formulations have been shown to possess varied biofilm activity, depending on whether they are prepared via traditional methods or chemical extractions (Lyles et al, 2017). Further, sesame oil is itself known to possess antimicrobial properties (Nigam et al, 2015;Heidari-Soureshjani, 2016;Lavaee et al, 2019). Remedies of each type of medicinal plant, Kalanchoe pinnata (Lam.)…”

“…Based on historical findings, we reconstituted three traditional plant-based remedies in sesame oil, Kalanchoe pinnata or "Parnabeeja," Ocimum tenuiflorum or "Tulsi," Cynodon dactylon or "Durva." Sesame seed oil (Sesamum indicum) is known to possess antimicrobial properties (Nigam et al, 2015;Heidari-Soureshjani, 2016;Lavaee et al, 2019), and is widely used as an "oil pulling" agent to combat dental plaque formation (Anand et al, 2008;Thaweboon et al, 2011;Naseem et al, 2017;Shanbhag, 2017). In an in vitro model of oral infection with saliva-coated microtiter plates, sesame oil displayed antibacterial activity against S. mutans biofilms.…”