“…Previous studies have reported considerable biological activities when substitution occurs at position 1-, 3- and 5- of the pyrazoline ( Figure 1 ), such as anticonvulsant, antimalarial [ 2 ], anti-cardiovascular [ 3 ], anticancer [ 4 ], anti-amoebic [ 5 ], antimicrobial [ 6 , 7 ] and anti-tumor activities [ 8 ]. Meanwhile, carbothioamide derivatives were found to have significant pharmacological activities, such as monoamine oxidase (MAO) inhibitors [ 9 , 10 ], antituberculosis [ 11 , 12 , 13 ] and anticonvulsant activities [ 14 , 15 , 16 ].…”