Effect of wet mass on dextromethorphan hydrobromide matrix pellets

Ibrahim, Mohamed A.; Mahrous, Gamal M.

doi:10.1590/s2175-97902018000400228

Cited by 4 publications

(5 citation statements)

References 25 publications

(24 reference statements)

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“…3. Consequently, a typical torque profile that has been reported in previous studies on other powders (for instance, pharmaceutical powder 11,20,23,33,34) ) was obtained even in the case of iron ore powders.…”

Section: Torque Profile As a Function Of Water Contentsupporting

confidence: 66%

“…The measurement of the agitation torque of wet powder has been employed for pharmaceutical powders. 13,[23][24][25] It has been demonstrated that the optimum water content for wet granulation of pharmaceutical powders can be determined based on their PL value. 13,23,25) However, there has been no attempt to utilize the agitation torque of ore powders to determine the optimum water content for wet granulation of iron ore powders.…”

Section: Determining Optimum Water Content For Iron Ore Granulation U...mentioning

confidence: 99%

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Determining Optimum Water Content for Iron Ore Granulation using Agitation Torque of Wet Ore Powder

et al. 2022

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Wet granulation of iron ore powders is a key process in ironmaking. In wet granulation, it is important to determine the optimum content of water added to the original ore powders. To determine the optimum water content, it is important to understand the saturation state in wet ore powder, which can be done by measuring the agitation torque of the wet powder. This study proposes a methodology for determining the optimum water content of various iron ore powders using the agitation torque of wet ore powders. First, measurement of the agitation torque and wet granulation of various iron ore powders were conducted. By comparing the results, it was found that the optimum water content, which was defined as the minimum water content required to diminish fine particles in the original powder, corresponded to the water content exhibiting the maximum agitation torque, regardless of the original powder. Using the agitation torque at different water contents, the saturation degree S, which is the volume ratio of water to the interparticle voids, was calculated, resulting in a range of 0.999 ≤ S ≤ 1.173 at the optimum water content. This suggests that the state between the funicular and capillary states is a suitable saturation state for the wet granulation of ore powders. Consequently, it was demonstrated that it is possible to determine the optimum water content for wet granulation of various iron ore powders based on the water content exhibiting the maximum agitation torque of wet ore powders.

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Section: Torque Profile As a Function Of Water Contentsupporting

confidence: 66%

Section: Determining Optimum Water Content For Iron Ore Granulation U...mentioning

confidence: 99%

Determining Optimum Water Content for Iron Ore Granulation using Agitation Torque of Wet Ore Powder

et al. 2022

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“…A low pellet wet mass consistency enables easy extrusion of pellets and yields small pellets with smoother surfaces. A similar finding was obtained by Ibrahim and Mahrous [22].…”

Section: Effect On Pellet Sizesupporting

confidence: 91%

“…The required volume of the PVP solution was added, and the powder was wetted with the binder solution for 10 min. The obtained wet mass was then subjected to extrusion through a screen pore size of 1 mm Ø (Mini Screw Extruder, Model MSE1014; Caleva, Dorset, UK) at an extrusion speed of 100 rpm [22]. Consequently, the produced rod-shaped extrudates were spheronized for 5-7 min at a speed of 700 rpm using a rotating plate of even cross-hatch geometry (Spheronizer Model 120; Caleva, Dorset, UK).…”

Section: Extrusion/spheronization Proceduresmentioning

confidence: 99%

Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization

Ibrahim

Alshora

2021

Polymers

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Aceclofenac (AC) is a nonsteroidal anti-inflammatory drug used in the treatment of chronic pain in conditions such as rheumatoid arthritis, with frequent administration during the day. The formulation of sustained release matrix pellets can provide a promising alternative dosage form that controls the release of the drug, with less blood fluctuation and side effects—especially those related to the gastric system. The extrusion/spheronization technique was used to formulate AC matrix pellets. The response surface methodology (version 17.2.02.; Statgraphics Centurion) was used to study the impacts of Eudragit RL 100 and PVP K90 binder solution concentrations on the pellets’ wet mass peak torque, pellet size, and the release of the drug. Statistically, a significant synergistic effect of PVP K90 concentration on the peak torque and pellet size was observed (p = 0.0156 and 0.031, respectively), while Eudragit RL 100 showed significant antagonistic effects (p = 0.042 and 0.013, respectively). The peak torque decreased from 0.513 ± 0.022 to 0.41 ± 0.021 when increasing the Eudragit RL 100 from 0 to 20%, and the pellet size decreased from 0.914 ± 0.047 to 0.789 ± 0.074 nm. The tested independent factors did not significantly affect the drug release in the acidic medium within 2 h, but these pellet formulae maintained the drug release at less than 10% in the acidic medium (pH 1.2), which may decrease gastric irritation side effects. In contrast, a highly significant synergistic effect of Eudragit and highly antagonistic effect of the PVP solution on drug release in the alkaline-pH medium were observed (p = 0.002 and 0.007, respectively). The optimized pellet formula derived from the statistical program, composed of 3.21% Eudragit and 5% PVP solution, showed peak torque of 0.861 ± 0.056 Nm and pellet size of 1090 ± 85 µm, and resulted in a significant retardation effect on the release after 8 h compared to the untreated drug.

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“…However, these methods are empirical and trial-and-error. As a comprehensive method to determine the optimum water content, the effectiveness of agitation torque measurement has been reported 10,[20][21][22] ; however, these studies focused on the wet granulation process of organic powders such as pharmaceutical materials 10,[20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Optimum Water Content Estimation for Wet Granulation of Iron Ore Powders with Quicklime Binder

et al. 2023

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water content () for estimating the optimum water content ( ) was individually defined 𝑊 torque 𝑊 exp opt for the types I and II. The was well correlated with the , regardless of the type and 𝑊 torque 𝑊 exp opt blending ratio of the original ore powders and quicklime. Finally, the optimum water content was estimated using the . The estimated water content was confirmed to be in good agreement 𝑊 torque with the experimental results, demonstrating that the optimum water content for the wet granulation of fine ore powder with quicklime can be determined using agitation torque.

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Effect of wet mass on dextromethorphan hydrobromide matrix pellets

Cited by 4 publications

References 25 publications

Determining Optimum Water Content for Iron Ore Granulation using Agitation Torque of Wet Ore Powder

Determining Optimum Water Content for Iron Ore Granulation using Agitation Torque of Wet Ore Powder

Development and Characterization of Eudragit-RL-100-Based Aceclofenac Sustained-Release Matrix Pellets Prepared via Extrusion/Spheronization

Optimum Water Content Estimation for Wet Granulation of Iron Ore Powders with Quicklime Binder

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