Determination of cefotaxime, cefoperazone, ceftazidime and cefadroxil using surface plasmon resonance band of silver nanoparticles

Abstract

The aim of this work is to evaluate simple, sensitive, effective and validated procedures for the determination of cefotaxime, cefoperazone, ceftazidime and cefadroxil. In this study, the methods based on the ability of the cited drugs to reduce Ag + ions to silver nanoparticles (Ag-NPs) in the presence of Polyvinyl Pyrrolidone (PVP) as a stabilizing agent producing very intense surface plasmon resonance peak of Ag-NPs (λ max. = 410-430 nm). The plasmon absorbance of the Ag-NPs allows the quantitative spectrophotometric determination of the cited drugs. The calibration curves are linear with concentration ranges of 0.4-3.2, 1-8, 0.5-4.0 and 1.5-9.0 µg/mL for cefotaxime, cefoperazone, ceftazidime and cefadroxil, respectively. Apparent molar absorptivity, detection and quantitative limits are calculated. Applications of the proposed methods to representative pharmaceutical formulations are successfully presented. The extracellular synthesis of nanoparticles is fast, and the method doesn ' t require various elaborate treatments and tedious extraction procedures.

An Overview of the Polymeric Materials that can be Used to Prevent Metal Corrosion: A Review

“…Numerous analysts have as of late centred around corrosion avoidance strategies utilizing green inhibitors for mild steel in acidic solution for imitate modern procedures. Some papers suggested triazines, anilinopropionates, polymers, dyes, drugs, ionic liquids, natural products (plant extract) N-(6methoxyquinolin-4-yl)-pentane-1,4-diamine (MPD), N'-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4diamine (CDPD), thiosemicarbazide, phenyl isothiocyanate, N-phenylhydrazine-1,2dicarbothioamide (PDA) and azorubine dye (AZB), streptomycin, cephalexin, ceftadizime (CZD), and eco-friendly polyaspartic acid (PASP) (25,(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) as different effective class of corrosion inhibitors on mild steel in HCl and H2SO4 solution interface and found the inhibitor efficiency to be about 90% and more respectively. To increase the counter consumption and scale restriction properties of metal surfaces, an uncovered multi-use bearer of mesoporous titanium dioxide whiskers (TiO2(w) (41) was contrived in epoxy covering and altered by ethylenediamine tetra (methylene phosphonic corrosive) (EDTMPA) and imidazoline, whereas (42) ginger concentrate as consumption inhibitor from normal assets was concentrated to forestall corrosion of mild steel in corrosive media.…”

Voltammetric study of cefotaxime at the macroscopic and miniaturized interface between two immiscible electrolyte solutions

“…Cefotaxime (CTX, Fig. 1C) is the most active among third-generation CFS, particularly against Gram-negative bacteria as compared with the 1st and 2nd CFS generations [2]. In humans, these antibiotics are often used to treat urinary and respiratory tract bacterial infections.…”

The synthesis, characterization and applications of poly[N-isopropylacrylamide-co-3-allyloxy-1,2-propanediol] grafted onto modified magnetic nanoparticles

“…2 It is also used in the empirical therapy of febrile neutropenia in combination with other antibiotics. 3 The analysis of ceazidime is performed by HPLC, 4 UV/Vis, 5 GC/MS, [6][7][8][9] LC/MS, 10,11 IR, 12 LC/MS/MS, 13 capillary electrophoresis, [14][15][16] and chemiluminescence 17 in biological samples. Recently, magnetic nanoparticles (MNPs) have been widely used as drug carriers due to their size, shape, and magnetic eld.…”