Preparation, characterization, and antiproliferative activities of biotin-decorated docetaxel-loaded bovine serum albumin nanoparticles

Cheng, Kai; Sun, Song Yung; Gong, Xianfeng

doi:10.1590/s2175-97902018000217295

Cited by 10 publications

(5 citation statements)

References 48 publications

(42 reference statements)

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“…A further improvement of docetaxelloaded nanoparticles is to functionalize the surface of the albumin-based nanoparticles with ligands able to recognize specific receptors on the surface of the tumor. In the case of docetaxel, Cheng et al 118 formulated biotin-decorated docetaxel-loaded BSA nanoparticles to specifically target the corresponding receptors of carcinoma. The nanoparticles were prepared via desolvation technique and cross-linked with glutaraldehyde at the end.…”

Section: Albumin-based Formulations For the Delivery Of Other Therape...mentioning

confidence: 99%

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

et al. 2021

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Albumin is an appealing carrier in nanomedicine because of its unique features. First, it is the most abundant protein in plasma, endowing high biocompatibility, biodegradability, nonimmunogenicity, and safety for its clinical application. Second, albumin chemical structure and conformation allows interaction with many different drugs, potentially protecting them from elimination and metabolism in vivo, thus improving their pharmacokinetic properties. Finally, albumin can interact with receptors overexpressed in many diseased tissues and cells, providing a unique feature for active targeting of the disease site without the addition of specific ligands to the nanocarrier. For this reason, albumin, characterized by an extended serum half-life of around 19 days, has the potential of promoting half-life extension and targeted delivery of drugs. Therefore, this article focuses on the importance of albumin as a nanodrug delivery carrier for hydrophobic drugs, taking advantage of the passive as well as active targeting potential of this nanocarrier. Particular attention is paid to the breakthrough NAB-Technology, with emphasis on the advantages of Nab-Paclitaxel (Abraxane), compared to the solventbased formulations of Paclitaxel, i.e., CrEL-paclitaxel (Taxol) in a clinical setting. Finally, the role of albumin in carrying anticancer compounds is depicted, with a particular focus on the albumin-based formulations that are currently undergoing clinical trials. The article sheds light on the power of an endogenous substance, such as albumin, as a drug delivery system, signifies the importance of the drug vehicle in drug performance in the biological systems, and highlights the possible future trends in the use of this drug delivery system.

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Section: Albumin-based Formulations For the Delivery Of Other Therape...mentioning

confidence: 99%

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

et al. 2021

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“…XRD results of D-BSA NPs cross-linked by catechol-V(III) coordination showed a weak broad signal between 15 and 40°( 2θ) which originated from the amorphous structure of NPs (Figure S4). 57,58 However, aggregates of D-BSA proteins upon acetone addition decomposed in water without V(III)-based cross-linking. The pictures of samples obtained with the crosslinker of V(III) and without V(III) are also shown in Figure S5.…”

Section: Synthesis and Characterization Of D-bsa Proteinmentioning

confidence: 99%

Dopamine-Conjugated Bovine Serum Albumin Nanoparticles Containing pH-Responsive Catechol-V(III) Coordination for In Vitro and In Vivo Drug Delivery

Argitekin,

Ersoz-Gulseven,

Cakan-Akdogan

et al. 2023

Biomacromolecules

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V(III) instead of commonly used Fe(III) provided a rich tris-catechol-metal coordination at pH 7.4, which is important for slow drug release at physiological pH. Bovine serum albumin (BSA) functionalized with catechol-containing dopamine (D) and cross-linked using tris-catechol-V(III) coordination yielded pH-responsive compact D-BSA NPs (253 nm). However, conversion to bis- and/or mono-catechol-V(III) complexes in an acidic medium resulted in degradation of NPs and rapid release of doxorubicin (DOX). It was shown that D-BSA NPs entered cancerous MCF-7 cells (66%) more efficiently than non-cancerous HEK293T (33%) in 3 h. Also, DOX-loaded NPs reduced cell viability of MCF-7 by 75% and induced apoptosis in a majority of cells after 24 h. Biodegradability and lack of hemolytic activity were shown in vitro, whereas a lack of toxicity was shown in histological sections of zebrafish. Furthermore, 30% of circulating tumor cells in vasculature in 24 h were killed by DOX-loaded NPs shown with the zebrafish CTC xenograft model.

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“…The PDI values observed for the formulations were lower than 0.26. Lower PDI indicated good dispersibility, a prerequisite of good stability (Cheng, Sun, Gong, 2018;Danaei et al, 2018) indicating that the nanoparticles were homogenous and had narrow size distribution. The qualitative-quantitative composition and method of preparation of the nanoparticles are determinants of the mean diameter and the polydispersity of the particles (Sharma, Madan, Lin, 2016).…”

Section: The Size Distribution Pi and Zp Of The Polymeric Nanoparticlementioning

confidence: 99%

Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

Rodrigues

Couto

Sinisterra

et al. 2020

Braz. J. Pharm. Sci.

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This paper reports on the development of nanoparticles aiming at the in vitro controlled release of simvastatin (SVT). The nanoparticles were prepared by the nanoprecipitation method with polymers Eudragit ® FS30D (EDGFS) or Eudragit ® NE30D (EDGNE). EDGFS+SVT nanoparticles showed mean size of 148.8 nm and entrapment efficiency of 76.4%, whereas EDGNE+SVT nanoparticles showed mean size of 105.0 nm and entrapment efficiency of 103.2%. Infrared absorption spectra demonstrated that SVT incorporated into the polymer matrix, especially EDGNE. Similarly, the differential scanning calorimeter (DSC) curve presented no endothermic peak of fusion, indicating that the system is amorphous and the drug is not in the crystalline state. The maintenance of SVT in the amorphous state may favors its solubilization in the target release sites. In the in vitro dissolution assay, the SVT incorporated into the EDGFS+SVT nanoparticles showed a rapid initial release, which may be related to the pH of the dissolution medium used. Regarding the EDGNE+SVT nanoparticles, the in vitro release occurred in a bimodal behavior, i.e., an initial "burst" followed by a sustained delivery, with the kinetics of drug release following Baker-Lonsdale's mathematical model. All these features suggest the nanoparticulate system's potential to modulate SVT delivery and enhance its bioavailability.

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Preparation, characterization, and antiproliferative activities of biotin-decorated docetaxel-loaded bovine serum albumin nanoparticles

Abstract: The aim of the present study was to characterize biotin-decorated docetaxel-loaded bovine serum albumin nanoparticles (DTX-BIO-BSA-NPs) and evaluate their antiproliferative activity in vitro. The particle size of prepared DTX-BIO-BSA-NPs was found to be always lower than

Cited by 10 publications

References 48 publications

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

The Uniqueness of Albumin as a Carrier in Nanodrug Delivery

Dopamine-Conjugated Bovine Serum Albumin Nanoparticles Containing pH-Responsive Catechol-V(III) Coordination for In Vitro and In Vivo Drug Delivery

Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

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