Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline

Abstract

The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary phase diagrams were constructed and based on smaller droplet size (24.8 nm), minimum viscosity (153.63 cP) and polydispersity index (0.182), higher percentage transmittance (95%) and in vitro drug release (97%), an optimum system was designated. Liquid SNEDDS was transformed into free-flowing powder by solid adsorption technique followed by compression into tablets. In vitro release of sertraline from liquid and solid SNEDDS was found to be highly significant compared to plain sertraline (p<0.01). Pharmacokinetic studies after oral administration of liquid and solid SNEDDS in rats showed about 6-and 5-fold increased absorption of sertraline compared to the aqueous suspension of sertraline. These studies demonstrate that the solid SNEDDS are promising strategies for successful delivery of poorly water-soluble drug like sertraline.

A Solid Ultra Fine Self-Nanoemulsifying Drug Delivery System (S-SNEDDS) of Deferasirox for Improved Solubility: Optimization, Characterization, and In Vitro Cytotoxicity Studies

“…The increase in the percentage of DFX released from S-SNEDDS formulations is likely due to the spontaneous formation of nanoemulsion with small globules in the nano size once contacted with the dissolution media, which results in higher surface area, which permits a faster rate of drug release and extent [ 34 ]. That could induce a higher absorption and higher oral bioavailability of DFX.…”

Spray-dried nanoemulsion for improved oral delivery of silymarin against hepatic cancer cells

“…The drug content was determined by reported method with slight modification 23 . The instrument for analysis was Shimadzu LC-10AT VP equipped with C18 column (25 cm x 4.6 mm, 5 mm particle size) and UV detector (Shimadzu, Kyoto, Japan).…”

Capsaicin Loaded Solid SNEDDS for Enhanced Bioavailability and Anticancer Activity: In-Vitro, In-Silico, and In-Vivo Characterization

“…Dispersibility, an indication of selfeemulsification time of the developed nano-system was determined as reported by Rahman & Mujahid. 34 In brief, 1 mL of each capsaicin loaded L-SNEDDS was added to 500 mL of 0.1 N HCl maintained at 37 ± 0.5 C in the USP type II dissolution apparatus (Electrolab, India). The whole system was agitated at 50 rpm & visually observed for the appearance, optical clarity, precipitation & further categorized using the grading system, viz.…”

“…Initially, each LeSNEDDS (L-CAP-1 to L-CAP-3) was centrifuged at 3500 rpm for 30 min. Systems that showed no signs of phase separation were subjected to heating (45 C) & cooling cycles (4 C) for 48 h. Formulations stable to heatingecooling cycles were further subjected to freezeethaw cycles operated between À21 C & þ25 C. 25,34,35 Cloud Point Measurements Each nano emulsifying system was diluted 250 times with water, kept in a water bath & heated gradually. The temperature corresponding to the cloudy phase appearance in each system was reported.…”