Spectrophotometric determination of rosuvastatin in pharmaceutical formulations using quinalizarin

Abstract

This work presents the development of a methodology based on the formation of a charge transfer complex between quinalizarin and rosuvastatin, allowing for the spectrophotometric determination of rosuvastatin at 579 nm. The factors involved in the sensitivity of the technique were studied (nature and proportion of the solvent, reaction time, pH of aqueous phase and quinalizarin concentration). The proposed spectrophotometric procedures were validated with respect to linearity, ranges, precision, accuracy, detection and quantification limits. Calibration curves of the formed color products showed good linear relationships over the concentration range of 6-15 mg L -1 . The proposed method has been successfully applied, which can be confirmed by interference test (comparison between the standard curves and addition of analyte), method precision (RSD 2.3% to 6 mg L -1 ), and by accuracy (statistically equivalent results between the proposed method and a chromatographic method of reference).

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review

“…Spectrophotometric methods with UV-Visible detection have been developed for ROS analysis alone and in simultaneous determination as presented in Table 1. [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64] The matrices most employed in the studies were standard and pharmaceutical formulations, except for the spectrofluorimetric method developed by Braga et al [53] , which analyzed ROS in urine samples. The solvent most employed in spectrophotometric method was methanol (MeOH).…”

“…Derivative spectrophotometric determination of ROS was performed with the respective reagents and wavelength detection: safranin at 530 nm, methylene blue at 655 nm, iodine at 291 and 360 nm, quinalizarin at 579 nm, and bromocresol green at 416 nm. [50][51][52]54] Spectrophotometric methods were developed for the estimation of ROS combined with fenofibrate in dosage formulations. [57,59,61,62] Considering the analysis of ROS in combination or alone, the linearity was observed in concentrations from 0.48 mg/mL to 500 mg/mL, nevertheless, in most cases, the typical range was around 1-10 mg/mL.…”

A novel sustainable second‐derivative synchronous spectrofluorimetric method for the simultaneous determination of olmesartan medoxomil and rosuvastatin calcium in bulk and formulations: Integrated greenness and whiteness evaluation

“…These methods are available for determining OML either in formulations or in biological samples. Similarly, a literature review for ROS, either singly or in combination, includes LC-MS/MS [19,20], HPLC [21][22][23][24], spectrophotometry [25][26][27][28], and spectrofluorimetry [29][30][31]. Only two analytical methods for the measurement of OML and ROS in pharmaceutical dosage forms using RP-HPLC have been provided to date [3,32].…”

Quantitative Analysis of Rosuvastatin Calcium in Bulk and Solid Pharmaceutical Dosage Forms Using Green and Rapid Fourier-Transform Infrared Spectroscopic Method

“…Various methods have been developed so far by the analysts across the globe for the assessment of rosuvastatin calcium in individual or combined dosage form based on various analytical techniques. Those established method includes spectrophotometric [7][8][9][10][11][12][13][14][15][16] , High Performance Liquid Chromatography (HPLC) , Ultra Performance Liquid Chromatography (UPLC) [51,52] , electrode [53] , High Performance Thin Layer Chromatography (HPTLC) [54,55] , Capillary zone www.ijpsonline.com…”