Hepatoprotective effect of Phytosome Curcumin against paracetamol-induced liver toxicity in mice

Abstract

Curcuma longa, which contains curcumin as a major constituent, has been shown many pharmacological effects, but it is limited using in clinical due to low bioavailability. In this study, we developed a phytosome curcumin formulation and evaluated the hepatoprotective effect of phytosome curcumin on paracetamol induced liver damage in mice. Phytosome curcumin (equivalent to curcumin 100 and 200 mg/kg body weight) and curcumin (200 mg/kg body weight) were given by gastrically and toxicity was induced by paracetamol (500 mg/kg) during 7 days. On the final day animals were sacrificed and liver function markers (ALT, AST), hepatic antioxidants (SOD, CAT and GPx) and lipid peroxidation in liver homogenate were estimated. Our data showed that phytosome has stronger hepatoprotective effect compared to curcumin-free. Administration of phytosome curcumin effectively suppressed paracetamol-induced liver injury evidenced by a reduction of lipid peroxidation level, and elevated enzymatic antioxidant activities of superoxide dismutase, catalase, glutathione peroxidase in mice liver tissue. Our study suggests that phytosome curcumin has strong antioxidant activity and potential hepatoprotective effects.Uniterms: Curcumin/effects. Curcumin/antioxidant activity. Curcuma longa. Phytosome. Hepatoprotective.

Formulation and Evaluation of Phytosome-Loaded Maltodextrin-Gum Arabic Microsphere System for Delivery of Camellia sinensis Extract

“…The results were in accordance with the results obtained by Tung, Hai, and Son in 2017, 16 where the vesicles formed have a spherical shape. The results were shown in Figure. Particle Size Distribution, Polydispersity Index, and Zeta potential DLS method can also measure the polydispersity index (PDI).…”

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

“…Several agents, such as alcohol, drugs, pollutants, parasites, and dietary components, among others, can trigger acute and chronic liver injuries, including liver fibrosis, non-alcoholic steatohepatitis, non-alcoholic liver disease, and even cirrhosis. Curcumin has been extensively studied for its hepatoprotective effects (Rahmani et al, 2016;Tung et al, 2017;Peng et al, 2018;Macıás-Peŕez et al, 2019). Choudhury et al (2016) demonstrated that a curcumin injection (8.98 µM) in Swiss albino rats with CCl 4 -induced hepatotoxicity decreased the NADH oxidase level and increased the GR and GST levels and succinate dehydrogenase activity.…”

“…Several agents, such as alcohol, drugs, pollutants, parasites, and dietary components, among others, can trigger acute and chronic liver injuries, including liver fibrosis, non-alcoholic steatohepatitis, non-alcoholic liver disease, and even cirrhosis. Curcumin has been extensively studied for its hepatoprotective effects ( Rahmani et al., 2016 ; Tung et al., 2017 ; Peng et al., 2018 ; Macías-Pérez et al., 2019 ).…”

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

“…Nanoparticulated curcumin has been evidenced to maintain cellular ROS levels, increase cellular antioxidant enzymes, prevent excessive mitochondrial destruction, and decrease fatty changes and inflammation in CCl 4 -treated rat hepatocytes [ 112 ]. Enzymes, such as aspartate aminotransferase (AST) and alanine transaminase (ALT), in serum, are the main liver transaminases for liver damage assessment, and the hepatic GSH content indicates oxidative stress in the liver [ 113 ]. Turmeric extract and curcumin are found to suppress CCl 4 -induced hepatic oxidative stress.…”