Intradialytic aerobic training improves inflammatory markers in patients with chronic kidney disease: a randomized clinical trial

Cruz, Lucas; Zanetti, Hugo Ribeiro; Andaki, Alynne Christian Ribeiro; Mota, Gustavo Ribeiro da; Neto, Octávio Barbosa; Mendes, Edmar Lacerda

doi:10.1590/s1980-657420180003e017517

Cited by 10 publications

(23 citation statements)

References 29 publications

(14 reference statements)

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“…Hemodialysis, as renal replacement therapy, could lead to changes in QoL and the health status of patients with CKD [ 19 ]. In this regard, exercise and physical activity could influence the physical, psychological and social factors of patients undergoing hemodialysis [ 40 ]. One of the influential factors, which has recently been of interest is the hemodialysis patients’ perception of exercise benefits and barriers [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis patients perceived exercise benefits and barriers: the association with health-related quality of life

et al. 2021

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Background Patients on hemodialysis have less exercise capacity and lower health-related quality of life than healthy individuals without chronic kidney disease (CKD). One of the factors that may influence exercise behavior among these patients is their perception of exercise benefits and barriers. The present study aimed to assess the perception of hemodialysis patients about exercise benefits and barriers and its association with patients’ health-related quality of life. Methods In this cross-sectional study, 227 patients undergoing hemodialysis were randomly selected from two dialysis centers. Data collection was carried out using dialysis patient-perceived exercise benefits and barriers scale (DPEBBS) and kidney disease quality of life short form (KDQOL-SF). Data were analyzed using SPSS software ver. 21. Results The mean score of DPEBBS was 68.2 ± 7.4 (range: 24 to 96) and the mean KDQOL score was 48.9 ± 23.3 (range: 0 to 100). Data analysis by Pearson correlation coefficient showed a positive and significant relationship between the mean scores of DPEBBS and the total score of KDQOL (r = 0.55, p < 0.001). Moreover, there was a positive relationship between the mean scores of DPEBBS and the mean score of all domains of KDQOL. Conclusion Although most of the patients undergoing hemodialysis had a positive perception of the exercise, the majority of them do not engage in exercise; it could be contributed to the barriers of exercise such as tiredness, muscle fatigue, and fear of arteriovenous fistula injury. Providing exercise facilities, encouraging the patients by the health care provider to engage in exercise programs, and incorporation of exercise professionals into hemodialysis centers could help the patients to engage in regular exercise.

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Section: Discussionmentioning

confidence: 99%

Hemodialysis patients perceived exercise benefits and barriers: the association with health-related quality of life

et al. 2021

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“…The 24 studies included were conducted in Iran [ 19 ], Brazil [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], Poland [ 30 ], the United Kingdom [ 31 , 32 , 33 , 34 , 35 , 36 ], Taiwan [ 37 ], China [ 38 ], Indonesia [ 39 ], Spain [ 40 , 41 ] and Greece [ 42 ], and published from 2010 to 2022.…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the included studies are presented in Table 1 . The 24 studies were clinical trials, of which thirteen were randomized controlled trials [ 19 , 25 , 26 , 27 , 28 , 29 , 35 , 36 , 37 , 38 , 39 , 41 , 42 ], four were uncontrolled trials [ 20 , 21 , 30 , 40 ], one was a non-randomized clinical trial [ 23 ], one was a non-randomized controlled trial [ 32 ], four were randomized crossover trials [ 22 , 24 , 31 , 33 ], and one was a non-randomized crossover trial [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…The methodological quality of the studies was evaluated with the PEDro scale, and scores are shown in Table 2 . In total, seventeen studies were evaluated as being of excellent quality [ 19 , 22 , 24 , 25 , 26 , 27 , 28 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 ], two studies were of good quality [ 23 , 29 ] and five studies were of acceptable quality [ 20 , 21 , 30 , 32 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

Meléndez‐Oliva

Villafañe

Pérez

et al. 2022

JPM

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Background: In recent years, physical exercise has been investigated for its potential as a therapeutic tool in patients with end-stage renal disease (ESRD) undergoing hemodialysis maintenance treatment (HD). It has been shown that regular practice of moderate-intensity exercise can improve certain aspects of immune function and exert anti-inflammatory effects, having been associated with low levels of pro-inflammatory cytokines and high levels of anti-inflammatory cytokines. Purpose: The aim of this review is to examine the studies carried out in this population that analyzed the effect of intradialytic exercise on the inflammatory state and evaluate which exercise modality is most effective. Methods: The search was carried out in the MEDLINE, CINAHL Web of Science and Cochrane Central Register of Controlled Trials databases from inception to June 2022. The PEDro scale was used to assess methodological quality, and the Cochrane Risk of Bias Tool and MINORS were used to evaluate the risk of bias. The quality of evidence was assessed with GRADE scale. The outcome measures were systemic inflammation biomarkers. Results: Mixed results were found in terms of improving inflammation biomarkers, such as CRP, IL-6 or TNFα, after exercise. Aerobic exercise seems to improve systemic inflammation when performed at medium intensity while resistance training produced better outcomes when performed at high intensity. However, some studies reported no differences after exercise and these results should be taken with caution. Conclusions: The low quality of the evidence suggests that aerobic and resistance exercise during HD treatment improves systemic inflammation biomarkers in patients with ESRD. In any case, interventions that increase physical activity in patients with ESRD are of vital importance as sedentary behaviors are associated with mortality. More studies are needed to affirm solid conclusions and to make intervention parameters, such as modality, dose, intensity or duration, sufficiently clear.

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“…The current literature showed that both types of physical exercise (warming and aerobic physical exercises) have a positive impact on physical outcomes such as improving inflammatory markers [20], and psychological outcomes such as depression [7]. Furthermore the literature revealed the feasibility and safety for conducting the physical exercises during dialysis session [7] [16].…”

Section: Physical Exercises Among Patients Undergoing Hemodialysismentioning

confidence: 99%

The Effectiveness of Physical Exercise on Psychological Status, and Sleep Quality among Jordanian Patients Undergoing Hemodialysis: Literature Review

Alradaydeh¹,

Khalil²

2019

OJN

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Background: Patients receiving hemodialysis are suffered from several psychological complications, and they required to receive safe, feasible, and applicable interventions to improve their psychological health. Practicing physical exercises were used in the literature as a possible intervention to improve patient's outcomes. Purpose: The current literature review aimed to evaluate the effectiveness of physical exercises on psychological status, and sleep quality among patients undergoing hemodialysis, and to detect the gab in the Jordanian literature about the effectiveness of practicing physical exercises on psychological status, and sleep quality among patients undergoing hemodialysis. Methods: The design of the current article was literature review of fifty studies. Results: The current review revealed that most of the research studies were conducted to describe the levels and prevalence's of psychological and mental complication of hemodialysis process, and to evaluate the impact of different types and methods of physical exercises on physical, psychological, and functional outcomes among patients undergoing hemodialysis. However, there are no agreement about the type, time, and intensity of physical exercises, and its impact on patients' psychological outcomes. In Jordanian context, there are no experimental studies were conducted about the effectiveness of physical exercises on psychological status and sleep quality among patients undergoing hemodialysis. Conclusion: It is imperative for researchers to fill the gap that existed in the body of knowledge regarding the effectiveness of physical exercises on psychological outcomes among patients undergoing hemodialysis in order to improve psychological well-being and improve both quality of life for patients, and quality of nursing care.

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Intradialytic aerobic training improves inflammatory markers in patients with chronic kidney disease: a randomized clinical trial

Cited by 10 publications

References 29 publications

Hemodialysis patients perceived exercise benefits and barriers: the association with health-related quality of life

Hemodialysis patients perceived exercise benefits and barriers: the association with health-related quality of life

Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

The Effectiveness of Physical Exercise on Psychological Status, and Sleep Quality among Jordanian Patients Undergoing Hemodialysis: Literature Review

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