Effect of preconditioning and postoperative hyperbaric oxygen therapy on colonic anastomosis healing with and without ischemia in rats

Fontoura-Andrade, José Luiz; Pinto, Leonardo Mendes; Carneiro, Fabiana Pirani; Sousa, João Batista de

doi:10.1590/s0102-865020200050000003

Cited by 3 publications

(3 citation statements)

References 29 publications

(47 reference statements)

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“…Concurrently, another investigation revealed that during lung ischemia–reperfusion, the release of mitochondrial DNA (mtDNA) induces the formation of TLR9-mediated NETs, intensifying lung injury [ 175 ]. Given that injuries from bowel anastomosis are essentially ischemic reperfusion injuries or arise from tissue hypoxia [ 176 ], it is possible that the generation of NETs has a negative impact on the repair of tissues affected by ischemia and hypoxia. Contrarily, in vitro analyses have indicated that under suboptimal concentrations, NETs might bolster the proliferation of keratinocytes, driven by the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway [ 177 ].…”

Section: Reviewmentioning

confidence: 99%

Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation

Lu,

Elrod,

Herrmann

et al. 2024

Cells

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Post-surgical abdominal adhesions, although poorly understood, are highly prevalent. The molecular processes underlying their formation remain elusive. This review aims to assess the relationship between neutrophil extracellular traps (NETs) and the generation of postoperative peritoneal adhesions and to discuss methods for mitigating peritoneal adhesions. A keyword or medical subject heading (MeSH) search for all original articles and reviews was performed in PubMed and Google Scholar. It included studies assessing peritoneal adhesion reformation after abdominal surgery from 2003 to 2023. After assessing for eligibility, the selected articles were evaluated using the Critical Appraisal Skills Programme checklist for qualitative research. The search yielded 127 full-text articles for assessment of eligibility, of which 7 studies met our criteria and were subjected to a detailed quality review using the Critical Appraisal Skills Programme (CASP) checklist. The selected studies offer a comprehensive analysis of adhesion pathogenesis with a special focus on the role of neutrophil extracellular traps (NETs) in the development of peritoneal adhesions. Current interventional strategies are examined, including the use of mechanical barriers, advances in regenerative medicine, and targeted molecular therapies. In particular, this review emphasizes the potential of NET-targeted interventions as promising strategies to mitigate postoperative adhesion development. Evidence suggests that in addition to their role in innate defense against infections and autoimmune diseases, NETs also play a crucial role in the formation of peritoneal adhesions after surgery. Therefore, therapeutic strategies that target NETs are emerging as significant considerations for researchers. Continued research is vital to fully elucidate the relationship between NETs and post-surgical adhesion formation to develop effective treatments.

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Section: Reviewmentioning

confidence: 99%

Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation

Lu,

Elrod,

Herrmann

et al. 2024

Cells

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“…Individual weight loss greater than 20% of baseline weight at any point in the experiment was identified as a humane endpoint. 16…”

Section: Estimation Of Body Weight Of Animalsmentioning

confidence: 99%

Study of Morphological Changes in Rat Liver Caused by Occlusion of Inferior Vena Cava

Tanabayeva¹,

Almabayev²,

Kamyspaev³

et al. 2022

Journal of Clinical and Experimental Hepatology

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“…Conversely, Fontoura-Andrade et al have compared pre and postoperative hyperbaric oxygen therapy on anastomosis in rats, using 100% oxygen at a maximal pressure of 2.4 atmospheres for 60 min in two preoperative sessions and four postoperative ones. They concluded that the HBOT does not change the outcome of anastomosis healing (41). Nowadays, HBOT represents just a support to prevent anastomotic dehiscence.…”

Section: Pathological Consequencesmentioning

confidence: 99%

Revisited Hyperoxia Pathophysiology in the Perioperative Setting: A Narrative Review

et al. 2021

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The widespread use of high-dose oxygen, to avoid perioperative hypoxemia along with WHO-recommended intraoperative hyperoxia to reduce surgical site infections, is an established clinical practice. However, growing pathophysiological evidence has demonstrated that hyperoxia exerts deleterious effects on many organs, mainly mediated by reactive oxygen species. The purpose of this narrative review was to present the pathophysiology of perioperative hyperoxia on surgical wound healing, on systemic macro and microcirculation, on the lungs, heart, brain, kidneys, gut, coagulation, and infections. We reported here that a high systemic oxygen supply could induce oxidative stress with inflammation, vasoconstriction, impaired microcirculation, activation of hemostasis, acute and chronic lung injury, coronary blood flow disturbances, cerebral ischemia, surgical anastomosis impairment, gut dysbiosis, and altered antibiotics susceptibility. Clinical studies have provided rather conflicting results on the definitions and outcomes of hyperoxic patients, often not speculating on the biological basis of their results, while this review highlighted what happens when supranormal PaO2 values are reached in the surgical setting. Based on the assumptions analyzed in this study, we may suggest that the maintenance of PaO2 within physiological ranges, avoiding unnecessary oxygen administration, may be the basis for good clinical practice.

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Effect of preconditioning and postoperative hyperbaric oxygen therapy on colonic anastomosis healing with and without ischemia in rats

Abstract: Conception and design of the study, technical procedures, acquisition and interpretation of data, statistics analysis, manuscript preparation and writing, critical revision, final approval.

Cited by 3 publications

References 29 publications

Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation

Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation

Study of Morphological Changes in Rat Liver Caused by Occlusion of Inferior Vena Cava

Revisited Hyperoxia Pathophysiology in the Perioperative Setting: A Narrative Review

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