Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice

Wang, Qian; Zhao, Yang; Zhang, Bin

doi:10.1590/s0102-865020200020000004

Cited by 5 publications

(1 citation statement)

References 30 publications

(29 reference statements)

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“…Cytokines IL-10 and IL-13 are considered as anti-inflammatory and upregulated in acute liver injury and liver fibrosis to prevent the damage [ 23 , 45 , 46 ]. Song et al have reported that using sirolimus as an immunosuppressive drug resulted in increased level of IL-10 in liver transplant patients by affecting B cell regulatory cells [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Short-Term Tacrolimus Exposure on Rat Liver: An Insight into Serum Antioxidant Status, Liver Lipid Peroxidation, and Inflammation

Fatima

Sheikh

Satoskar

et al. 2021

Mediators of Inflammation

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Tacrolimus (TAC) is an immunosuppressive drug, optimally used for liver, kidney, and heart transplant to avoid immune rejection. In retrospect, a multitude of studies have reported effects of TAC, such as nephrotoxicity, diabetes, and other complications. However, limited information is available regarding short-term exposure of TAC on the liver. Therefore, the present study was designed to unravel the effects of short-term exposure of TAC on a rat model. The animal model was established by TAC administration for 6, 12, 24, and 48 h time points. Liver histopathological changes were observed with PAS-D, reticulin stain, and immunostaining of PCNA and CK-7 coupled with glycogen quantification in a liver homogenate. TUNEL assay was performed to evaluate the DNA damage in the liver. Concentration of GSH and activities of SOD and CAT in the serum were measured to assess the antioxidant status, whereas liver tissue MDA level was measured as a biomarker of oxidative stress. Hepatic gene expression analysis of IL-10, IL-13, SOCS-2, and SOCS-3 was performed by RT-PCR. Results revealed marked changes in liver architecture of all TAC-treated groups, as evidenced by sinusoid dilation, hepatocyte derangement, glycogen deposition, and collapsed reticulin fibers. Significant increase in PCNA and CK-7 immunostaining along with the presence of TUNEL-positive cells was revealed in treatment groups as compared to the control group. Serum antioxidant enzyme status was markedly decreased, whereas the liver MDA level was increased in TAC treatment groups indicating oxidative stress induction. The gene expression profile of cytokines was significantly upregulated in treatment groups highlighting an inflammatory response. In conclusion, results of the current study propose that even a short-term TAC exposure can induce change in antioxidant status and lipid peroxidation. Therefore, these factors should be considered to avoid and minimize immunosuppression-related issues in a prolonged course of treatment.

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Section: Discussionmentioning

confidence: 99%

Effect of Short-Term Tacrolimus Exposure on Rat Liver: An Insight into Serum Antioxidant Status, Liver Lipid Peroxidation, and Inflammation

Fatima

Sheikh

Satoskar

et al. 2021

Mediators of Inflammation

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show abstract

Luteolin-7-O-rutinoside from Pteris cretica L. var. nervosa attenuates LPS/D-gal-induced acute liver injury by inhibiting PI3K/AKT/AMPK/NF-κB signaling pathway

Xiong

Cui

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Platycodon grandiflorus Polysaccharide with Anti-Apoptosis, Anti-Oxidant and Anti-Inflammatory Activity Against LPS/D-GalN Induced Acute Liver Injury in Mice

Cheng

et al. 2021

J Polym Environ

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Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice

Abstract: Conception and design of the study, critical revision, supervised all phases of the study.

Cited by 5 publications

References 30 publications

Effect of Short-Term Tacrolimus Exposure on Rat Liver: An Insight into Serum Antioxidant Status, Liver Lipid Peroxidation, and Inflammation

Effect of Short-Term Tacrolimus Exposure on Rat Liver: An Insight into Serum Antioxidant Status, Liver Lipid Peroxidation, and Inflammation

Luteolin-7-O-rutinoside from Pteris cretica L. var. nervosa attenuates LPS/D-gal-induced acute liver injury by inhibiting PI3K/AKT/AMPK/NF-κB signaling pathway

Platycodon grandiflorus Polysaccharide with Anti-Apoptosis, Anti-Oxidant and Anti-Inflammatory Activity Against LPS/D-GalN Induced Acute Liver Injury in Mice

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