Expression of stromal elements of prostatic adenocarcinoma in different gleason scores

Osorio, Clarice Fraga Esteves Maciel; Costa, Waldemar S.; Gallo, C.; Sampaio, Francisco J.B.

doi:10.1590/s0102-865020190100000005

Cited by 6 publications

(2 citation statements)

References 23 publications

(33 reference statements)

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“…Patients’ data also show a strong positive correlation between collagen-mediated tumor stiffness and tumor evolution and aggressiveness. Recently, the quantification of ECM elements in prostate adenocarcinoma of different Gleason scores revealed an increase of collagen fibers in the tumor area compared to the non-tumor area [ 72 ]. Gleason score is the standard grading system used to assess the disease’s aggressiveness [ 73 , 74 ].…”

Section: The Extracellular Matrix Stiffness Contributes To the Progre...mentioning

confidence: 99%

The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?

Luthold

Hallal

Labbé

et al. 2022

Cancers

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Despite advancements made in diagnosis and treatment, prostate cancer remains the second most diagnosed cancer among men worldwide in 2020, and the first in North America and Europe. Patients with localized disease usually respond well to first-line treatments, however, up to 30% develop castration-resistant prostate cancer (CRPC), which is often metastatic, making this stage of the disease incurable and ultimately fatal. Over the last years, interest has grown into the extracellular matrix (ECM) stiffening as an important mediator of diseases, including cancers. While this process is increasingly well-characterized in breast cancer, a similar in-depth look at ECM stiffening remains lacking for prostate cancer. In this review, we scrutinize the current state of literature regarding ECM stiffening in prostate cancer and its potential association with disease progression and castration resistance.

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Section: The Extracellular Matrix Stiffness Contributes To the Progre...mentioning

confidence: 99%

The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?

Luthold

Hallal

Labbé

et al. 2022

Cancers

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“…1,7,16 Derajat diferensiasi adenokarsinoma prostat ditentukan berdasarkan skor Gleason, yaitu diferensiasi baik (well differentiated) untuk skor Gleason ≤6, diferensiasi sedang (moderate differentiated) untuk skor Gleason 7, dan diferensasi buruk (poorly differentiated) untuk skor Gleason 8-10. 17,18 Pengukuran prognosis kanker prostat menggunakan prognostic grade group (PGG) yang diadopsi oleh WHO 2016 dari Konsensus ISUP 2014. 15 Prognostic grade group pada penelitian diberi skor sesuai dengan gradenya, misal PGG 1 nilai skor 1, PGG 2 nilai skor 2 dan seterusnya untuk memudahkan analisis.…”

Section: Deteksi Ekspresi Estrogen Receptor Menggunakan Metode Immuno...unclassified

Hubungan Ekspresi Estrogen Receptor Dengan Skor Gleason, Derajat Diferensiasi, Dan Prognostic Grade Group Pada Adenokarsinoma Prostat

Ulfaningtyas

Norahmawati

Anita

et al. 2021

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Kanker prostat yang didominasi oleh adenokarsinoma prostat adalah salah satu keganasan yang sering didapatkan pada laki-laki. Studi terkini menyebutkan bahwa estrogen receptor berhubungan dengan kanker prostat. namun masih didapatkan kontroversi hubungan reseptor ini dengan kanker prostat dan prognosis kanker prostat. Sejauh ini, di Indonesia belum ada penelitian yang dilakukan untuk mencari hubungan ER dengan prognosis pasien kanker prostat. Penelitian ini bertujuan untuk membuktikan adanya hubungan antara ekspresi ER dengan skor Gleason, derajat diferensiasi, dan prognostic grade group pasien adenokarsinoma prostat. Desain penelitian adalah observasional analitik, menggunakan 31 sampel adenokarsinoma prostat berdasarkan perhitungan statistik. Ekspresi ER diukur pada kelompok spesimen jaringan adenokarsinoma prostat, yang kemudian dilakukan uji korelasi Spearman terhadap skor Gleason, derajat diferensiasi serta prognostic grade group (PGG). Pada penelitian ini didapatkan nilai p > 0,05 pada uji korelasi spearman antara ekspresi reseptor estrogen terhadap skor Gleason (p = 0,601), derajat diferensiasi (p = 0,754 ) dan prognostic grade group (p = 0,596) pada adenokarsinoma prostat. Hasil penelitian juga menunjukkan kecenderungan rerata ekspresi reseptor estrogen pada kelompok poorly differentiated adenokarsinoma prostat lebih tinggi dibandingkan kelompok moderately differentiated. Namun, pada prognostic grade group terdapat kecenderungan rerata ekspresi reseptor estrogen meningkat pada PGG yang lebih tinggi. Kesimpulannya, tidak didapatkan korelasi yang bermakna antara ekspresi reseptor estrogen dengan skor Gleason, derajat diferensiasi, dan prognostic grade group pada adenokarsinoma prostat. Disarankan untuk menentukan prognosis kanker prostat dari berbagai aspek, tidak hanya dari skor Gleason, derajat diferensiasi, dan prognostic grade group, tetapi juga mempertimbangkan stadium TNM dan kadar prostate spesific antigen (PSA).

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Zonal regulation of collagen‐type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry

et al. 2020

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BackgroundThe emergence of reactive stroma is a hallmark of prostate cancer (PCa) progression and a potential source for prognostic and diagnostic markers of PCa. Collagen is a main component of reactive stroma and changes systematically and quantitatively to reflect the course of PCa, yet has remained undefined due to a lack of tools that can define collagen protein structure. Here we use a novel collagen‐targeting proteomics approach to investigate zonal regulation of collagen‐type proteins in PCa prostatectomies.MethodsProstatectomies from nine patients were divided into zones containing 0%, 5%, 20%, 70% to 80% glandular tissue and 0%, 5%, 25%, 70% by mass of PCa tumor following the McNeal model. Tissue sections from zones were graded by a pathologist for Gleason score, percent tumor present, percent prostatic intraepithelial neoplasia and/or inflammation (INF). High‐resolution accurate mass collagen targeting proteomics was done on a select subset of tissue sections from patient‐matched tumor or nontumor zones. Imaging mass spectrometry was used to investigate collagen‐type regulation corresponding to pathologist‐defined regions.ResultsComplex collagen proteomes were detected from all zones. COL17A and COL27A increased in zones of INF compared with zones with tumor present. COL3A1, COL4A5, and COL8A2 consistently increased in zones with tumor content, independent of tumor size. Collagen hydroxylation of proline (HYP) was altered in tumor zones compared with zones with INF and no tumor. COL3A1 and COL5A1 showed significant changes in HYP peptide ratios within tumor compared with zones of INF (2.59 ± 0.29, P value: .015; 3.75 ± 0.96 P value .036, respectively). By imaging mass spectrometry COL3A1 showed defined localization and regulation to tumor pathology. COL1A1 and COL1A2 showed gradient regulation corresponding to PCa pathology across zones. Pathologist‐defined tumor regions showed significant increases in COL1A1 HYP modifications compared with COL1A2 HYP modifications. Certain COL1A1 and COL1A2 peptides could discriminate between pathologist‐defined tumor and inflammatory regions.ConclusionsSite‐specific posttranslational regulation of collagen structure by proline hydroxylation may be involved in reactive stroma associated with PCa progression. Translational and posttranslational regulation of collagen protein structure has potential for new markers to understand PCa progression and outcomes.

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Expression of stromal elements of prostatic adenocarcinoma in different gleason scores

Cited by 6 publications

References 23 publications

The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?

The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?

Hubungan Ekspresi Estrogen Receptor Dengan Skor Gleason, Derajat Diferensiasi, Dan Prognostic Grade Group Pada Adenokarsinoma Prostat

Zonal regulation of collagen‐type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry

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