Comparison of the prognostic value of platelet-based prognostic models in patients with malignant hepatic tumors after TACE therapy

Du, Qian; Hu, Chen; Wang, Yan Yan; Zhou, Ying

doi:10.1590/s0102-865020190070000010

Cited by 2 publications

(4 citation statements)

References 36 publications

(36 reference statements)

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“…), and lipid metabolism (including apolipoprotein A, total cholesterol, etc.) [15][16][17][18][19][20][21]. However, few of them have achieved worldwide acknowledgment.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma Receiving Transarterial Chemoembolization

Chen

Jiang

et al. 2021

The Oncologist

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Purpose. To investigate the predictive capability of Neutrophil-to-Apolipoprotein A1 ratio (NAR) for predicting overall survival (OS) among hepatocellular carcinoma (HCC) patients receiving transarterial chemoembolization (TACE). Patients and methods. We investigated the clinical features of 554 HCC patients receiving TACE and assessed NAR's predictive value for OS with 222 consisting the discovery cohort and 332 consisting the validation cohort. The association of NAR with circulation LOX-1 + polymorphonuclear myeloidderived suppressor cells (PMN-MDSC) were illustrated. Results. Multivariate Cox regression revealed lymphocyte count, TNM stage and NAR were independent prognostic factors in discovery cohort. Validation cohort confirmed the independent prognostic value of TNM stage and NAR. Patients with low NAR (<2.7) displayed significantly increased OS in the discovery cohort (59.8 months vs 21 months), validation group (38.0 months vs 23.6 months) and the total cohort (44.1 months vs 22.0 months). Then Cox proportional hazards model was conducted to combine Cancer of the Liver Italian Program (CLIP) score with discretized NAR. C-index illustrated that NAR integrated CLIP score was best model compared with NAR and CLIP score. Furthermore, NAR-CLIP presented superior predictive capacity for 10, 20, 30, 40, 50 and 60-month survival compared with CLIP by survival ROC analysis in the discovery cohort, validation cohort and total cohort. NAR was significantly associated with LOX-1 + PMN-MDSC by linear regression. Conclusion. In summary, the present study identified NAR as an independent predictor for OS among HCC patients receiving TACE. NAR reflected circulation LOX-1 + PMN-MDSC level. The Oncologist 2021;9999:• • Implications for Practice: The present study identified Neutrophil-to-Apolipoprotein A1 Ratio (NAR) as an independent predictor for overall survival among hepatocellular carcinoma patients receiving Transarterial Chemoembolization. NAR reflected circulation LOX-1+ PMN-MDSC level.

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“…), and lipid metabolism (including apolipoprotein A, total cholesterol, etc.) [15][16][17][18][19][20][21]. However, few of them have achieved worldwide acknowledgment.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma Receiving Transarterial Chemoembolization

Chen

Jiang

et al. 2021

The Oncologist

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“…A previous study by Du et al (32) analyzed the prognostic value of PLT-based prognostic scores in patients with advanced malignant hepatic tumors who had received transarterial chemoembolization (TACe) therapy and reported that APgA is an independent risk factor for the overall survival rate. however, the present study determined the performance value of various scoring systems on the prognostic of patients with malignant hepatic tumors who received various types of therapy, including TACe and hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

“…however, the present study determined the performance value of various scoring systems on the prognostic of patients with malignant hepatic tumors who received various types of therapy, including TACe and hepatectomy. In addition, only a small number of cases were included in previous studies and these studies only focused on the overall survival rate of patients (25,32).…”

Section: Discussionmentioning

confidence: 99%

“…Although recent studies have demonstrated that abnormal PLT counts are associated with a poor prognosis in patients with cancer, this association remains controversial (27,28). In addition, previous studies have reported a correlation between PLT-based models and the recurrence and overall survival rate in patients with malignant hepatic tumors (15,(29)(30)(31)(32). In the present study, 18 PLT-based models were used to predict the overall survival and recurrence-free survival in patients with malignant hepatic tumors.…”

Section: Introductionmentioning

confidence: 87%

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Relationship between platelet‑based models and the prognosis of patients with malignant hepatic tumors

Wang

et al. 2020

Oncol Lett

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Platelets (PLTs) are involved in tumor growth, metabolism and vascular activation. PLT-based models have been reported to have significant value on the recurrence of malignant hepatic tumors. The present study aimed to investigate the effect of PLT count and 18 PLT-based models on the prognosis of patients with malignant hepatic tumors. The clinical data from 189 patients with malignant hepatic tumors were retrospectively analyzed and used to calculate the scores of the 18 PLT-based models. Receiver operating characteristic curve was used to determine the suitable cutoff values of mortality and recurrence in patients with malignant hepatic tumors. The overall survival and cumulative recurrence rates of patients were calculated using Kaplan-Meier survival curves and the difference was analyzed using log-rank test. Multivariate analysis was performed to determine the independent risk factors of recurrence-free survival and overall survival. In the present study, 11 models were considered as predictors of mortality (P<0.05) and six models were considered as predictors of recurrence (P<0.05). The results from multivariate analysis demonstrated that vascular cancer embolus, uric acid >231 µmol/l, hemoglobin >144 g/l and the Lok index model >0.695 were considered as independent risk factors of mortality (P<0.05). Furthermore, vascular cancer embolus, PLT to lymphocyte ratio (PLR) >175 and fibrosis-4 (FIB-4) >4.82 were independent factors of recurrence (P<0.05). In addition, the results from this study indicated that the Lok-index could be considered as a predictor of the overall survival rate. In conclusion, the FIB-4 and PLR model may be valuable for predicting the recurrence-free rate of patients with malignant hepatic tumors.

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Comparison of the prognostic value of platelet-based prognostic models in patients with malignant hepatic tumors after TACE therapy

Abstract: Intellectual, scientific, conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis; manuscript preparation, final approval.

Cited by 2 publications

References 36 publications

Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma Receiving Transarterial Chemoembolization

Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma Receiving Transarterial Chemoembolization

Relationship between platelet‑based models and the prognosis of patients with malignant hepatic tumors

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