Relationship between serum MMP-9 level and prognosis after radical resection for Hilar cholangiocarcinoma patients

Abstract

Purpose: To analyze the preoperative serum matrix metalloproteinase-9 (MMP-9) levels and prognosis of patients with hilar cholangiocarcinoma (HC) undergoing radical resection. Methods: Preoperative serum MMP-9 levels in patients with HC undergoing radical resection were detected by enzyme-linked immunosorbent assay (ELISA). The ROC curve assay was used to analyze the preoperative serum MMP-9 level to determine the most valuable cut-off point. The relationship between MMP-9 and clinicopathological features of HC patients was analyzed. Kaplan-Meier method was used to analyze the prognostic factors, and COX regression model was used to analyze the independent risk factors affecting prognosis. Results: Preoperative serum MMP-9 levels were significantly elevated in the death patients compared with the survival patients. The most valuable cut-off point for preoperative serum MMP-9 for prognosis was 201.93 ng/mL. Preoperative serum MMP-9 was associated with Bismuth-Corlette classification) and lymph node metastasis. Kaplan-Meier analysis showed that MMP-9, Bismuth-Corlette classification, Lymph node metastasis, Portal vein invasion, Hepatic artery invasion, Liver invasion, Incised margin, and Preoperative biliary drainage were related to prognosis. Cox regression model confirmed that hepatic artery invasion, liver invasion, incised margin, and MMP-9 have the potential to independence predicate prognosis in HC patients. Conclusion: Preoperative serum MMP-9 has high predictive value for prognosis and is an independent influencing factor for the prognosis of patients with hilar cholangiocarcinoma.

Bioinformatic analysis of the LCN2–SLC22A17–MMP9 network in cancer: The role of DNA methylation in the modulation of tumor microenvironment

“…Interestingly, the expression of both LNC2 and MMP9 genes was increased in 16 tumor types, demonstrating their involvement in tumor development. This result was consistent with those reported in the literature for several tumors, including BLCA ( Ricci et al, 2015 ; Candido et al, 2016b ), CESC ( Li et al, 2012 ), CHOL ( Leelawat et al, 2011 ; Nair et al, 2018 ; Li et al, 2019 ), ESCA ( Zhang et al, 2007 ), HNSC ( Ruokolainen et al, 2005 ; Hiromoto et al, 2011 ; Stanciu et al, 2016 ; Verma et al, 2017 ), KIRP ( Cho et al, 2003 ; Zhang et al, 2015 ), LIHC ( Chen et al, 2012 ; Abdelsameea et al, 2020 ), LUAD ( Ruiz-Morales et al, 2015 ), OV ( Cho and Kim, 2009 ; Gupta et al, 2022 ); PAAD ( Kaur et al, 2013 ), STAD ( Du et al, 2011 ), UCEC ( Cymbaluk-Płoska et al, 2017 ), COAD ( Yang et al, 2014 ; Ozemir et al, 2016 ; Liang and Chang, 2018 ), LUSC ( Lee et al, 2015 ), PRAD ( Ma et al, 2017 ; Muşlu et al, 2017 ; Ulusoy et al, 2021 ), READ ( Zhang et al, 2009 ; Annaházi et al, 2016 ), and THCA ( Barresi et al, 2012 ; Liu et al, 2019 ; Xu et al, 2019 ).…”

Effect of hepatic artery resection and reconstruction on the prognosis of patients with advanced hilar cholangiocarcinoma

“…Alanine amino transferase and AST can be used to evaluate the extent of hepatocellular injury, with the elevation of ALT being roughly parallel to the degree of cellular injury[ 18 , 19 ]. The vast majority of TBIL in the human body comes from aging red blood cells, which are metabolized by the liver.…”

Role of Leptin in Neoplastic and Biliary Tree Disease

“…The most used serum markers are carbohydrate antigen (CA19.9) and carcino-embryonic antigen (CEA). The sensitivity and specificity of these markers is low, and they cannot provide a certain diagnosis of cholangiocarcinoma, they can have high values even for benign disease (15,16).…”