Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy

Li, Hongxia; Liu, Bofeng; Gu, Chunyan; Zeng, Xiao; Liu, Yali; Zhang, Susu; Gong, Haiye; Shao, Yina; Yao, Zhenwei; An, Ruifang

doi:10.1590/s0102-865020190040000001

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…In this study, HMOX1 participated in the HIF-1 signaling pathway and angiogenesis pathway. HMOX1 has anti-in ammatory, anti-oxidative stress and anti-proliferation effects, can promote the survival of neurons and oligodendrocytes, and can reduce the degree of HIBD nerve damage [41][42]. In this study, EGR1 participated in the interleukin-1 mediated signaling pathway and GnRH signaling pathway.Previous studies have shown that ERG1 induced by hypoxia-ischemia can reduce the expression of BDNF and aggravate brain damage [43].We applied the GEO data set to verify 4 hematologic/immune systemspeci c genes and indirectly con rmed the continuous differential expression of ERG1 and HMOX1 in the pathogenesis of HIBD (24h-8 weeks).…”

Section: Discussionmentioning

confidence: 75%

Identification of Potential Biomarkers and Pathways in Neonatal Hypoxic-Ischemic Brain Injury: Based on Bioinformatics Technology

Li¹,

Li²,

Zhao³

et al. 2021

Preprint

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Background Neonatal hypoxic-ischemic brain damage (HIBD) is one of the most common serious diseases in newborns, with a high mortality and disability rate. This study aims to use the bioinformatics analysis to identify potential hematologic/immune systems tissue-specific genes and related signaling pathways neonatal HIBD.Methods Microarray datasets in HIBD were downloaded from the Gene Expression Omnibus database, and DEGs were identified by R software.Enrichment analyses were performed and protein–protein interaction networks were constructed to understand the functions and enriched pathways of DEGs and to identify central genes and key modules. Results In the cerebral cortex tissue with HIBD, 2598 DEGs were identified, including 2362 up-regulated and 236 down-regulated DEGs. In the blood with HIBD, 1442 DEGs were identified, including 540 up-regulated and 902 down-regulated DEGs. The results of biological processes and KEGG enrichment were very similar in DEGs of the two kinds of tissues, and both involved inflammation, immunity and apoptosis. The common DEGs of the two kinds of tissues also showed similar results in biological processes and KEGG enrichment.and four hematologic/immune system tissues specifically expressed potential biomarker genes were confirmed through a variety of methods, which were verified by GEO datasets and published experimental research. Conclusion The DEGs of HIBD including the potential peripheral biomarkers TYROBP, ITGAM, EGR1 and HMOX1, which may play a role in the pathogenesis of HIBD through inflammation and immune-mediated signaling pathways.

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Section: Discussionmentioning

confidence: 75%

Identification of Potential Biomarkers and Pathways in Neonatal Hypoxic-Ischemic Brain Injury: Based on Bioinformatics Technology

Li¹,

Li²,

Zhao³

et al. 2021

Preprint

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“…Brain injury is a critical complication in cholestasis/cirrhosis [139,140]. Several mechanisms have been proposed for cholestasis/cirrhosis-induced brain injury [139][140][141][142].…”

Section: Discussionmentioning

confidence: 99%

“…Brain injury is a critical complication in cholestasis/cirrhosis [139,140]. Several mechanisms have been proposed for cholestasis/cirrhosis-induced brain injury [139][140][141][142]. The first, and probably the most important one, is the disruption of the urea cycle in the liver and the accumulation of ammonia in plasma and brain tissue [139].…”

Section: Discussionmentioning

confidence: 99%

Cellular and mitochondrial taurine depletion in bile duct ligated rats: a justification for taurine supplementation in cholestasis/cirrhosis

Najibi¹,

Rezaei²,

Manthari³

et al. 2022

ceh

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Taurine (TAU) is a free amino acid abundant in the human body. Various physiological roles have been attributed to TAU. At the subcellular level, mitochondria are the primary targets for TAU function. Meanwhile, it has been found that TAU depletion is associated with severe pathologies. Cholestasis is a severe clinical complication that can progress to liver fibrosis, cirrhosis, and hepatic failure. Bile duct ligation (BDL) is a reliable model for assessing cholestasis/cirrhosis and related complications. The current study was designed to investigate the effects of cholestasis/cirrhosis on tissue and mitochondrial TAU reservoirs. Cholestatic rats were monitored (14 and 42 days after BDL surgery), and TAU levels were assessed in various tissues and isolated mitochondria. There was a significant decrease in TAU in the brain, heart, liver, kidney, skeletal muscle, intestine, lung, testis, and ovary of the BDL animals (14 and 42 days after surgery). Mitochondrial levels of TAU were also significantly depleted in BDL animals. Tissue and mitochondrial TAU levels in cirrhotic animals (42 days after the BDL operation) were substantially lower than those in the cholestatic rats (14 days after BDL surgery). These data indicate an essential role for tissue and mitochondrial TAU in preventing organ injury induced by cholestasis/cirrhosis and could justify TAU supplementation for therapeutic purposes.

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Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, Pgc-1α and Tfam genes involved in apoptosis and mitochondrial biogenesis in the striatum of male rats

et al. 2019

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Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy

Cited by 6 publications

References 22 publications

Identification of Potential Biomarkers and Pathways in Neonatal Hypoxic-Ischemic Brain Injury: Based on Bioinformatics Technology

Identification of Potential Biomarkers and Pathways in Neonatal Hypoxic-Ischemic Brain Injury: Based on Bioinformatics Technology

Cellular and mitochondrial taurine depletion in bile duct ligated rats: a justification for taurine supplementation in cholestasis/cirrhosis

Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, Pgc-1α and Tfam genes involved in apoptosis and mitochondrial biogenesis in the striatum of male rats

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