The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection

Abstract

Purpose To evaluate serum levels of high-sensitivity C-reactive protein (hs-CRP) in chronic gastritis patients to predict Helicobacter pylori (HP) infection, inflammatory activity, and precancerous lesions. Methods A total of 811 patients with upper gastrointestinal symptoms and histopathological diagnosis of chronic gastritis were enrolled in the study. On endoscopy, five gastric biopsies were taken according to Modified Sydney protocol, which were stained with hematoxylin & eosin and Giemsa Results HP infection was found in 28.6% of patients, being significantly more common in specimens with acute and chronic inflammatory activity. Mucosal atrophy, intestinal metaplasia, and dysplasia were found in 20.2%, 18.8% and 2.7% of biopsy specimens. Mean hs-CRP was 1.9±1.6 mg/dl for males and 2.2±1.9 mg/dl for females. hs-CRP average were significantly higher in patients with severe acute inflammation (p:0.049), in patients with severe chronic inflammation (p:0.015) and in those with HP (p: 0.001) . The severity of HP infection increased significantly with the increased degree of acute inflammation, chronic inflammation and hs-CRP level (p=0.001 for both). Conclusion Serum hs-CRP level increases in patients with chronic gastritis, it could be an indicator of severity of acute or chronic mucosal inflammation, and presence of HP infection. Therefore, hs-CRP may aid the diagnosis of chronic gastritis, but it is not associated with pre-cancerous lesions.

Biomarkers for Gastric Cancer Screening and Early Diagnosis

“…Another protein biomarker that could be useful to identify premalignant lesions is high-sensitivity C-reactive protein (hs-CRP). Altun et al studied serum levels of 811 patients, finding that those patients with chronic gastritis had higher levels of hs-CRP, although the authors suggested that this biomarker is not useful for cancer or precancerous lesions screening [56]. In another study on 378 patients, the authors found that a combination of serum hs-CRP levels and PGI:II ratio showed sensitivity and specificity values of 67% and 72% for the detection of IM patients.…”

Helikobakter Pilori Enfeksiyonu ile Nötrofil-Lenfosit Oranı, Trombosit-Lenfosit Oranı Ve Nötrofil-Monosit Oranları Arasındaki İlişki

“…Most patients have an asymptomatic but chronic inflammation (5). Previous studies have investigated several parameters such as leukocytes, C-reactive protein, and procalcitonin as markers of inflammation in HP-associated gastritis (6). Components of complete blood count (CBC), a simple and inexpensive test, such as leukocytes, neutrophils, lymphocytes, platelets, mean platelet volume (MPV), neutrophil-tolymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) can help differentiate the causes of hematological diseases and predict some inflammatory events.…”

The Role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratios in Predicting H Pylori Positivity And Severity in Patients with Chronic Gastritis

“…In societies with a low socioeconomic level, the infection rate is high, and gastritis occurs in almost all infected people. In previous studies, many parameters such as WBC, CRP, and procalcitonin were evaluated as an indicator of inflammation in gastritis due to H pylori 4 . Blood count devices can test the complete blood cell count (CBC), the white blood cells count (WBC), neutrophil, lymphocyte (LYM), platelet counts (PLT) parameters, such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).…”