Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation

Wang, Zhishun; Han, Qianqian; Guo, Yonglian; Liu, Xiuheng; Qiu, Tao

doi:10.1590/s0102-865020180030000006

Cited by 11 publications

(10 citation statements)

References 32 publications

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“…This effect can only be explained by the direct infusion of energy currents into mitochondria. Since abnormal inflammasome activation is a prominent feature of various chronic conditions like Alzheimer's, autoimmune disorders, cardiac and renal disease, as well as acute inflammatory syndromes like Covid-19, it has been suggested that ozone PC could modulate disease activity in these circumstances [168][169][170][171][172][173][174][175][176][177][178][179][180][181][182][183].…”

Section: Ozone Preconditioningmentioning

confidence: 99%

Ozone Preconditioning: Waking up the dragon

Thorp¹,

Thorp²

2021

The GMS

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It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science.

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Section: Ozone Preconditioningmentioning

confidence: 99%

Ozone Preconditioning: Waking up the dragon

Thorp¹,

Thorp²

2021

The GMS

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“… Morphology : alleviated the morphological damages, attenuated the injury of brush border of proximal renal tubular, restrained the expression level of NF- κBp65 in renal tissue, suppressed the expression of HMGB1 in renal tissue. ( Wang et al, 2018b ) 150 mg/kg, intraperitoneally, single dose for 10 days, at the same time Escherichia coli toxin (LPS) (20 mg/kg). Reduction : lactate dehydrogenase (LDH) (Liver, Kidney, Lungs, Heart).…”

Section: Effect Of Ozone Oxidative Preconditioning On Oxidative Stresmentioning

confidence: 99%

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Scassellati

Galoforo

Bonvicini

et al. 2020

Ageing Research Reviews

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Highlights Aging and neurodegenerative diseases are characterized by complex and multifactorial aetiology and challenges regarding treatments efficacy and costs persist. Oxygen-ozone (O 2 -O 3 ) therapy is a non-invasive, non-pharmacological, low cost and no-side effect procedure based on antioxidant capacity of O 3 . A plethora of scientific evidence supports other crucial properties of O 3 in physiopathological processes. Nrf2 is one of the principal molecular signalling on which O 3 exercises its antioxidant/anti-apoptotic/pro-autophagy effects, involved in aging and in neurodegenerative disorders. This review provides a consistent rationale to implement future clinical studies to apply the O 2 -O 3 treatment along with other antioxidants (polyphenols, mushrooms) in aging and in neurodegeneration.

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“…These data gave us a clue that HSP20 may possess certain degree of antioxidant properties. Of note, preconditioning of ozone has long been reported to be protective in animal organs against various kinds of oxidative insults in rats, such as liver ischaemia–reperfusion (I/R) injury [ 29 ], cisplatin-induced nephrotoxicity [ 30 ], renal transplantation [ 31 ], etc. Most of these studies reported the protective functions of ozone preconditioning were biophysiologically attributed to the maintenance of redox balance, of which the underlying mechanisms remain elusive.…”

Section: Discussionmentioning

confidence: 99%

Inducible expression of heat shock protein 20 protects airway epithelial cells against oxidative injury involving the Nrf2-NQO-1 pathway

Bao¹,

Ma²,

Zhang³

et al. 2020

Cell Biosci

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Background Heat shock protein (HSP) 20 is a molecular chaperone that exerts multiple protective functions in various kinds of tissues. However, the expression of HSP20 and its specific functions in airway epithelial cells (AECs) remain elusive. Results In current study, we first confirmed the inducible expression of HSP20 in mouse AECs and in a human bronchial epithelial cell line BEAS-2B cells, under different oxidant stressors. Then by establishing a HSP20-abundant mouse model with repeated low-level-ozone exposures and stimulating this model with a single high-level ozone exposure, we found that the HSP20 abundance along with its enhanced phosphorylation potentially contributed to the alleviation of oxidative injuries, evidenced by the decreases in the bodyweight reduction, the BAL neutrophil accumulation, the AECs shedding, and the BAL concentrations of albumin and E-cadherin. The biological function of HSP20 and its molecular mechanisms were further investigated in BEAS-2B cells that were transfected with HSP20-, unphosphorylatable HSP20(Ala) or empty vector plasmids prior to the stimulation of H2O2, of which its oxidant capacity has been proved to be similar with those of ozone in an air–liquid culture system. We found that the H2O2-induced intracellular ROS level and the early cell apoptosis were attenuated in the HSP20- but not HSP20(Ala)- transfected cells. The intracellular expression of NQO-1 (mRNA and protein) and the intranuclear content of Nrf2 were significantly increased in the HSP20- transfected cells but not in the HSP20(Ala)- and empty vector-transfected cells after the stimulation of H2O2. Conclusions The inducible expression of HSP20 in AECs by oxidative stress exerts protective roles against oxidative damages, which may involve the activation of the Nrf2-NQO-1 pathway.

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Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation

Abstract: Ozone oxidative preconditioning could attenuate the inflammatory reaction and oxidative stress injury in renal allograft, which might be related with the enhancement of anti-oxidative system and suppression of inflammatory reaction.

Cited by 11 publications

References 32 publications

Ozone Preconditioning: Waking up the dragon

Ozone Preconditioning: Waking up the dragon

Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders

Inducible expression of heat shock protein 20 protects airway epithelial cells against oxidative injury involving the Nrf2-NQO-1 pathway

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