The expression of endothelial and inducible nitric oxide synthase and apoptosis in intestinal ischemia and reperfusion injury under the action of ischemic preconditioning and pentoxifylline

Oliveira, Teresinha Regina Ribeiro de; F., Oliveira, Geraldo; Simões, Ricardo Santos; Feitosa, Suellen Maurim; Tikazawa, Eduardo Hiroshi; Monteiro, Hugo P.; Fagundes, Djalma José; Taha, Murched Omar

doi:10.1590/s0102-865020170110000005

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…Direkt mekanik önkoşullanmada doku uzun iskemi peryodu öncesi kısa süreli bir iskemiye maruz bırakılırken, farmakolojik önkoşullanmada ise çeşitli ajanlar bu amaçla kullanılmaktadır (21). Önkoşullanmanın epitelyal hücrelerde apoptozu engellediği, intestinal kontraktiliteyi koruduğu, proinflamatuar sitokin yapımında etki bir transkripsiyon faktörü olan nuklear faktör-kB (NF-kB) aktivasyonunu inhibe ettiği ve nitrik oksit yapımını artırdığı gösterilmiştir (22)(23)(24).…”

Section: Discussionunclassified

İntestinal İskemi/Reperfüzyon Modelinde Tiroid Hormon Ön Koşullanmasının İnce Bağırsak Ve Akciğer Hasarı Üzerine Etkisi

TURAN¹,

Özaçmak²,

Barut³

et al. 2017

MJWBS

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Section: Discussionunclassified

İntestinal İskemi/Reperfüzyon Modelinde Tiroid Hormon Ön Koşullanmasının İnce Bağırsak Ve Akciğer Hasarı Üzerine Etkisi

TURAN¹,

Özaçmak²,

Barut³

et al. 2017

MJWBS

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Ischemic Preconditioning Preventing Downregulation of miR-182 Protects Intestine Against Ischemia/Reperfusion Injury by Inhibiting Apoptosis

Luo

Duan

Bian

et al. 2019

Archives of Medical Research

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The role of atenolol in the modulation of the expression of genes encoding pro- (caspase-1) and anti- (Bcl2L1) apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats

et al. 2018

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Purpose: To investigate the role of atenolol in the gene expression of caspase 1 (Casp1) and Bcl2L1 on vascular endothelium of rat intestine after ischemia and reperfusion (IR). Methods: Eighteen adult male Wistar rats were randomly divided into 3 groups (n=6): SG (Sham group): no clamping of the superior mesenteric artery; IRG: IR plus saline group: IRG+At: IR plus Atenolol group. Rats from IRG and IRG+At were subjected to 60 min of intestinal ischemia and 120 min of reperfusion. Atenolol (2mg/kg) or saline were injected in the femoral vein 5 min before ischemia, 5 min and 55 min after reperfusion. Thereafter, intestinal segments were appropriately removed and processed for Endothelial Cell Biology Rat RT2 Profiler PCR Array. Results: the anti-apoptotic Bcl2L1 gene expression was significantly down-regulated (-1.10) in the IRG and significantly up-regulated in the IRG+At (+14.15). Meanwhile, despite Casp1 gene expression was upregulated in both groups, it was significantly higher in the IRG (+35.06) than the IRG+At (+6.68). Conclusions: Atenolol presents antiapoptotic effects on rat intestine subjected to IR partly by the up-regulation of the anti-apoptotic Bcl2L1 gene expression. Moreover, atenolol can mitigate the pro-apoptotic and pro-inflammatory effects of Casp1 gene on rat intestine after IR.

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The expression of endothelial and inducible nitric oxide synthase and apoptosis in intestinal ischemia and reperfusion injury under the action of ischemic preconditioning and pentoxifylline

Abstract: The BCL-2 and active caspase-3 showed beneficial effects on PTX and IPC. The expression of NOS-2 and NOS-3 in the IPC and IPC-PTX groups showed no synergistic effect.

Cited by 3 publications

References 29 publications

İntestinal İskemi/Reperfüzyon Modelinde Tiroid Hormon Ön Koşullanmasının İnce Bağırsak Ve Akciğer Hasarı Üzerine Etkisi

İntestinal İskemi/Reperfüzyon Modelinde Tiroid Hormon Ön Koşullanmasının İnce Bağırsak Ve Akciğer Hasarı Üzerine Etkisi

Ischemic Preconditioning Preventing Downregulation of miR-182 Protects Intestine Against Ischemia/Reperfusion Injury by Inhibiting Apoptosis

The role of atenolol in the modulation of the expression of genes encoding pro- (caspase-1) and anti- (Bcl2L1) apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats

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