Effects of long-term controlled internal drug release reuse on reproductive performance, hormone profiles, and economic profit of sheep

Abstract

ReproductionFull-length research article Effects of long-term controlled internal drug release reuse on reproductive performance, hormone profiles, and economic profit of sheep ABSTRACT -Fifty-seven multiparous Awassi ewes in the breeding season were used to compare the effects of controlled internal drug release (CIDR) reuse on hormone profiles, reproductive performance, and economic production. Ewes were randomly allotted to one of three CIDR treatments: new (control), once-used, and twice-used; treatment lasted 12 days. Blood samples were collected from all groups at the time of CIDR insertion, three and six days following insertion, at withdrawal time, and at insemination. Serum estradiol (E2) and progesterone (P4) concentrations were measured. Timed insemination was performed 48 h post CIDR withdrawal in all groups. Pregnancy was diagnosed by ultrasonography at day 23 post insemination. No significant differences were detected among groups in pregnancy rate/ewes in heat, twinning rate, fecundity, abortion rate, and prolificacy. However, estrus detection rate was significantly higher in control (100%) than in other groups. The P4 concentration was significantly higher in control than in other groups during treatment period; at insemination, P4 concentration was significantly higher in control than in other groups; at insemination time, E2 concentration was significantly higher in control than in the other groups; and the net profit was higher in once-used than in other groups. One-time reuse of CIDR for the long term (12 days) can synchronize estrus in ewes efficiently with higher net profit than the new or twice-used CIDR.

Estrous synchronization in sheep with reused progesterone devices and eCG

“…Despite the fact that long protocols based on P4 and eCG have been related with alterations in the quality of oocytes (development of persistent follicles, premature nuclear maturation) that determine low fertility rates and deteriorated embryonic development (Viñoles et al, 2001;Berlinguer et al, 2007;Swelum et al, 2019), in the present study, we obtained an adequate response in gestation rate and fertility with the association of long P4 protocols and 300 or 400 IU of eCG, although a higher gestation rate was obtained (93.75%) when using 10dCIDR and 300 IU eCG.…”

“…Several studies with reused CIDR have been conducted (Cox et al, 2012;Pinna et al, 2012;Bazzan et al, 2013;Silva et al, 2014) with 6-d protocols reusing CIDR up to three times in sheep, obtaining a good response to estrus (Vilariño et al, 2011;Swelum et al, 2018). The results indicate that the cost of CIDR is reduced when reusing it in long protocols (Swelum et al, 2019), which also Estrous synchronization in sheep with reused progesterone devices and eCG López-García et al reduces environmental contamination due to the lower amount of residual hormones in the device (Gonzalez-Bulnes et al, 2020).…”

Los dispositivos reutilizados en protocolos cortos de sincronización tienen el mismo efecto sobre el desempeño reproductivo y perfiles de progesterona en ovejas Pelibuey

“…Esto se debe a que la cantidad de P4 liberada de los dispositivos, depende de la etapa del ciclo estral en que la hembra se encuentre, siendo mayor las cantidades liberadas cuando las concentraciones endógenas son bajas (Vilariño et al, 2013). Los niveles de P4 residual en los dispositivos y las características de farmacocinética de liberación, hace posible reutilizar los dispositivos en programas cortos de sincronización del estro en ovejas (Vilariño et al, 2013) con ahorros de hasta un 60 % en comparación con los CIDR nuevos (Cox et al, 2012;Swelum et al, 2019).…”