Roles of Hedgehog signaling pathway in adipogenic differentiation potential of porcine adipose-derived mesenchymal stem cells

Fan, Caiyun; Zhang, Yunhai; Wang, Juhua; Cheng, Jianbo

doi:10.1590/rbz4720170019

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…In mice, subcutaneous fat pad and WAT decrease when the Hh pathway is activated (Li et al, 2008). Fan et al (2018) reported that Hh signaling primarily acts on the later stages of adipocytes differentiation in porcine adipose-derived MSCs. It was revealed that the expression pattern of Gli1, C/EBPα and PPARγ were changed on the fourth day of activation of the pathway.…”

Section: Hedgehog Signaling Pathwaymentioning

confidence: 99%

“…Inhibition of fat formation by Hh signaling pathway was retained both in vertebrates and invertebrates (Liang et al, 2015). While it has been revealed that activation of Hh signaling impairs adipogenesis, it is also counterintuitively reported that decrease or blockade of Hh pathway is necessary but not sufficient to trigger adipocyte differentiation (Fontaine et al, 2008;Fan et al, 2018).…”

Section: Hedgehog Signaling Pathwaymentioning

confidence: 99%

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Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

Ahmad¹,

Serpell²,

Fong³

et al. 2020

Front. Mol. Biosci.

122

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Obesity is now a widespread disorder, and its prevalence has become a critical concern worldwide, due to its association with common co-morbidities like cancer, cardiovascular diseases and diabetes. Adipose tissue is an endocrine organ and therefore plays a critical role in the survival of an individual, but its dysfunction or excess is directly linked to obesity. The journey from multipotent mesenchymal stem cells to the formation of mature adipocytes is a well-orchestrated program which requires the expression of several genes, their transcriptional factors, and signaling intermediates from numerous pathways. Understanding all the intricacies of adipogenesis is vital if we are to counter the current epidemic of obesity because the limited understanding of these intricacies is the main barrier to the development of potent therapeutic strategies against obesity. In particular, AMP-Activated Protein Kinase (AMPK) plays a crucial role in regulating adipogenesis -it is arguably the central cellular energy regulation protein of the body. Since AMPK promotes the development of brown adipose tissue over that of white adipose tissue, special attention has been given to its role in adipose tissue development in recent years. In this review, we describe the molecular mechanisms involved in adipogenesis, the role of signaling pathways and the substantial role of activated AMPK in the inhibition of adiposity, concluding with observations which will support the development of novel chemotherapies against obesity epidemics.

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Section: Hedgehog Signaling Pathwaymentioning

confidence: 99%

Section: Hedgehog Signaling Pathwaymentioning

confidence: 99%

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

Ahmad¹,

Serpell²,

Fong³

et al. 2020

Front. Mol. Biosci.

122

View full text Add to dashboard Cite

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Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

Bomkamp¹,

Musgrove

Marques

et al. 2022

Mar Biotechnol

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Cultivated meat, also known as cultured or cell-based meat, is meat produced directly from cultured animal cells rather than from a whole animal. Cultivated meat and seafood have been proposed as a means of mitigating the substantial harms associated with current production methods, including damage to the environment, antibiotic resistance, food security challenges, poor animal welfare, and—in the case of seafood—overfishing and ecological damage associated with fishing and aquaculture. Because biomedical tissue engineering research, from which cultivated meat draws a great deal of inspiration, has thus far been conducted almost exclusively in mammals, cultivated seafood suffers from a lack of established protocols for producing complex tissues in vitro. At the same time, fish such as the zebrafish Danio rerio have been widely used as model organisms in developmental biology. Therefore, many of the mechanisms and signaling pathways involved in the formation of muscle, fat, and other relevant tissue are relatively well understood for this species. The same processes are understood to a lesser degree in aquatic invertebrates. This review discusses the differentiation and maturation of meat-relevant cell types in aquatic species and makes recommendations for future research aimed at recapitulating these processes to produce cultivated fish and shellfish.

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Roles of Hedgehog signaling pathway in adipogenic differentiation potential of porcine adipose-derived mesenchymal stem cells

Cited by 2 publications

References 29 publications

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase

Differentiation and Maturation of Muscle and Fat Cells in Cultivated Seafood: Lessons from Developmental Biology

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