Can Hemophilia Impact on the Oral Health Conditions of Children and Adolescents? A Systematic Review and Metanalysis

Silva, Leandro Tavares da; Souza, Juliana Feltrin de; Wambier, Letícia Maíra; Menezes, José Vitor Nogara Borges de; Torres‐Pereira, Cassius Carvalho; Fraiz, Fabián Calixto

doi:10.1590/pboci.2022.053

Cited by 2 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, four duplicates were excluded. This led to 11 articles included for full-text review from which four articles were excluded [25][26][27][28] Table 1: List of excluded articles and reasons for exclusion. After a stringent full-text review, seven articles were included for final qualitative analysis, [13][14][15][19][20][21][22] Out of these final seven articles, four articles were included for quantitative analysis as control group was present in these four articles (Figure 3).…”

Section: Study Characteristicsmentioning

confidence: 99%

Prevalence of temporomandibular disorders (TMD) in bleeding disorders: A systematic review with meta‐analysis

Minervini,

Marrapodi,

Tirupathi

et al. 2023

J of Oral Rehabilitation

View full text Add to dashboard Cite

BackgroundHaemophilia A, B and von Willebrand disease are the most common bleeding disorders. There is an increased tendency of spontaneous bleeding into joints resulting in intra‐articular infection. It is believed that Temporomandibular Joint (TMJ) can be affected in a similar manner which can further lead to limited mouth opening and ankylosis. The association between bleeding disorders (BD) and development of temporomandibular disorders (TMD) is poorly understood. This systematic review intends to evaluate the association of TMD in individuals with inherited bleeding disorders as compared to healthy controls.MethodsPubMed, Ovid SP and Google Scholar were searched for articles published between the times of inception to 1 May 2023. All the articles were subjected to Population, Exposure, Comparison and Outcome model (PECO) based on which inclusion and exclusion criteria were applied. Participants (P) is children, adults or adolescents; Exposure (E) is children, adults or adolescents with a diagnosis of Haemophilia or bleeding disorder (BD); Comparator (C) is age and gender‐matched healthy controls who do not have Haemophilia or bleeding disorder; Outcome (O) is prevalence of any signs or symptoms (clinical, radiographic) that is suggestive of temporomandibular disorder (TMD). Studies showing the prevalence of TMD are included for qualitative analysis. Only the studies which provided data of the prevalence of TMD in both the groups (BD and healthy controls) were included in the quantitative analysis. TMD diagnosis can be by clinical signs and symptoms, radiographic criteria, Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) or any other imaging criteria (MRI). We have set the exclusion criteria as articles without a control group, diagnostic sensitivity studies, case reports and systematic reviews and narrative reviews. The software Review Manager version 5.4 (Cochrane Collaboration) was used to perform the pooled analysis. We measured the risk ratio (RR) between the two groups (BD and healthy controls) for the outcome TMD.ResultsA total of seven studies are included for qualitative analysis of data. The age of the population (BD and control) in the included studies ranged between 2 and 57 years. The prevalence of TMD in individual studies varied from 2% to 77%, and controls in the individual studies varied from 2% to 14%. Among the included studies, only clinical signs, symptoms and history were taken into consideration in four studies. Four studies were included for meta‐analysis, the pooled result of the four studies suggests there is no significant difference in the prevalence of TMD in BD and control group (p value = .11, RR 2.19; 95% CI [0.84, 5.73]).ConclusionThis systematic review and meta‐analysis elicits no association between bleeding disorders and increased prevalence of TMD.

show abstract

Section: Study Characteristicsmentioning

confidence: 99%

Prevalence of temporomandibular disorders (TMD) in bleeding disorders: A systematic review with meta‐analysis

Minervini,

Marrapodi,

Tirupathi

et al. 2023

J of Oral Rehabilitation

View full text Add to dashboard Cite

show abstract

Oral health in individuals with bleeding disorders: A systematic review and meta‐analysis

Bhadauria,

Purohit,

Nilima

et al. 2024

Haemophilia

View full text Add to dashboard Cite

BackgroundIndividuals with bleeding disorders have been reported to have a number of oral health issues due to varying conditions. A comprehensive evaluation of the different oral health conditions has not been carried out in the past. This systematic review and meta‐analysis was carried out to collate and critically analyse existing research, and provide a comprehensive overview of the current state of knowledge on oral health.MethodsA comprehensive search was conducted in electronic databases, including PubMed, Scopus and Embase, in October 2023. No restriction on time frame or language was applied. The risk of bias for cross‐sectional studies was assessed using the Agency for Healthcare Research and Quality (AHRQ) tool, and case control studies were assessed using the New Castle Ottawa Scale (NOS).ResultsTwenty‐two articles were included in the final analysis with a total sample size of 2422 subjects. Of the 22 articles assessed, nine quantitative assessments were included in the Meta analysis. Pooled data analysis was carried out. A total of 13 studies reported medium risk whereas the remaining nine studies showed low risk of bias. The weighted mean DMFT scores in individuals with bleeding disorders were found to be 2.43 [0.62. 4.24], mean dmft was 2.79 [1.05, 4.53] and mean OHI‐S was reported to be 1.79 [1.00, 2.57], respectively.ConclusionThe findings emphasize that these individuals have fair oral hygiene and lower dmft/DMFT scores. Oral bleeding emerged as an important oral health component to be cautiously dealt with particularly during the stages of exfoliation/shedding.

show abstract

Can Hemophilia Impact on the Oral Health Conditions of Children and Adolescents? A Systematic Review and Metanalysis

Cited by 2 publications

References 32 publications

Prevalence of temporomandibular disorders (TMD) in bleeding disorders: A systematic review with meta‐analysis

Prevalence of temporomandibular disorders (TMD) in bleeding disorders: A systematic review with meta‐analysis

Oral health in individuals with bleeding disorders: A systematic review and meta‐analysis

Contact Info

Product

Resources

About