Correlation Between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma

Torabi, Mehdi; Afshar, Marzieh Karimi; Afshar, Hooman Malekpour; Mohammahzadeh, Iman

doi:10.1590/pboci.2021.068

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This is not a common finding in the literature, and variations may be attributed to different clinical classifications of OLP, differing levels of interobserver variability, or adherence to stringent patient selection criteria [ 7 ]. The results of the present investigation were congruent with those of Torabi et al, who noted that the buccal mucosa is the most typical site for OLP, which can be ascribed to the epithelial thickness and the degree of keratinization [ 13 ]. According to De Sousa et al, the characteristic histological findings in OLP include lichenification of the basal layer, accompanied by a prominent layered lymphocytic infiltration explicitly beneath the epithelium; the existence of many eosinophilic colloid Civatte bodies along the epithelial-connective tissue interface; the lack of hyperplasic or, more frequently, saw-tooth interpapillary ridges; varying grades of orthokeratosis/parakeratosis; and differing thickness of spinous cellular layer [ 5 ].…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

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A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study

Vijayan¹,

Muthukrishnan²

2022

Cureus

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Objective: Based on the modified diagnostic criteria for oral lichen planus (OLP) proposed by Van der Meij and Van der Waal, the objective of the current investigation was to demonstrate a clinicohistopathological association in the diagnosis of OLP.Materials and methods: Data were retrieved from 250 individuals who visited the Department of Oral Medicine and Radiology and were diagnosed with OLP between September 2018 and December 2021. Upon completion of the histopathological analysis, the precise diagnosis of OLP was made. Repeat biopsies were performed in the cases suspecting malignant transformation during the follow-up phase. The data were analyzed using SPSS software. The Fisher's exact test and chi-square test of association were used to establish the significant differences between the variables at a 5% significance level.Results: Of the 250 patients, 48% and 52% were males and females, respectively. The two clinical manifestations observed were reticular (n=145, 58%) and erosive types (n=105, 42%). The most frequently impacted locations were the buccal mucosa (n=150, 60%) and labial mucosa (n=100, 40%). Fourteen individuals (two with reticular form and 12 with erosive form) later during follow-up showed dysplasia, with moderate (n=2) to mild (n=12) dysplastic alterations. Koilocytes were reported in 84 cases (34%), which included 35 (24%) reticular cases and 49 (47%) erosive lesions. The histopathological features such as acanthosis, epithelial atrophy, hyperkeratosis, presence of neutrophils, koilocytes, and epithelial dysplasia were shown to be statistically significant between the clinical forms (p<0.001). Conclusion:The results of the current study highlight the concordance of histopathological and clinical diagnoses, especially for early definitive diagnosis of OLP. More research studies are warranted to validate the trend of epithelial dysplasia in OLP associated with human papillomavirus (HPV) and to explore the course of the lesions that might be affected by this trait.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 85%

A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study

Vijayan¹,

Muthukrishnan²

2022

Cureus

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Clinical and histopathological correlation of oral malignancy and potentially malignant disorders based on a screening program at high-risk population in Tamil Nadu, India

Iyer,

Kumar,

Kannan

et al. 2023

Front. Oral. Health

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BackgroundThere is a high incidence of oral cancer and oral potential malignant disorder observed in southeast Asian countries such as India. Our study aimed to assess the correlation between screening and histopathological diagnosis and to predict the specificity and sensitivity of chair-side/field-based assessment of the oral lesion.Materials and methodsA total of 40,852 subjects aged between 20 and 60 years were screened in the 1st phase of the study, suspected lesions were stained with toluidine blue (Manufactured by Otto Chemicals private limited, India) at two time points, those who stained positively during the two points were taken up for biopsy. Provisional diagnosis was later correlated with histopathological diagnosis.ResultsSubjects who underwent biopsy had a mean age of (49.01 ± 9.8 years), Leukoplakia (1.5%) was the most common lesion observed among tobacco users, interestingly it had the least correlation (39.6%) in diagnosis, Overall sensitivity (88%) and a positive predictive value (80%) was high for clinical diagnosis of OPMD in our study.ConclusionCorrelation of clinical and histopathological diagnosis observed in our study confirms higher yield of true positives while screening in remote and vulnerable populations, which would assure a better quality of life for these subjects.

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Description of clinicopathological characteristics of oral potentially malignant disorders with special focus on two histopathologic grading systems and subepithelial inflammatory infiltrate

Khan,

Nisar

et al. 2023

Journal of Cancer Research and Therapeutics

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S Objective: This study was conducted to evaluate the clinicopathological features of oral potentially malignant disorders (OPMDs) with a focus on two histologic grading systems and subepithelial inflammatory infiltrates. Materials and Methods: This cross-sectional and multicenter study was conducted from April 2016 to September 2021 and comprised patients diagnosed with OPMDs. Hematoxylin and eosin-stained slides of 127 cases were assessed based on the World Health Organization (WHO) 2005 classification system, namely, epithelial precursor lesions and binary system of oral epithelial dysplasia (OED). Chi-square test and Fisher’s exact test were used to compare different categorical variables related to OPMDs. Results: The mean age of OPMD cases at presentation was 54.72 13.30 (P < 0.01) with a male to female ratio of 1.6:1. Oral leukoplakia (52.8%) was the most commonly diagnosed form of OPMD. Most OPMDs were classified as oral epithelial hyperplasia (59.1%) and the remaining (40.9%) as OED (P < 0.01). Of the 52 OPMDs with OED, all cases of mild dysplasia (36.5%) and carcinoma in situ (9.6%) were categorized as low-risk and high-risk lesions, respectively. Chronic inflammatory infiltrate (79.5%) was the most common subepithelial inflammatory alteration observed among OPMDs. Conclusions: Early detection of OPMDs is vital due to increased risk of developing into oral cancer. Timely clinicopathological risk assessment of OPMD is desirable for improving the prognosis and preventing the malignant transformation in oral premalignancy. Besides the epithelial precursor lesions’ classification by the WHO, binary system of grading OED use can be encouraged. Also, subepithelial inflammatory infiltrate can be of importance in future research regarding OPMDs.

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Correlation Between Clinical and Histopathologic Diagnosis of Oral Potentially Malignant Disorder and Oral Squamous Cell Carcinoma

Cited by 3 publications

References 30 publications

A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study

A Clinicohistopathological Characterization of Oral Lichen Planus: A Cross-Sectional Study

Clinical and histopathological correlation of oral malignancy and potentially malignant disorders based on a screening program at high-risk population in Tamil Nadu, India

Description of clinicopathological characteristics of oral potentially malignant disorders with special focus on two histopathologic grading systems and subepithelial inflammatory infiltrate

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