Effect of the Application of Chlorella Vulgaris Ointment to the Number of Fibroblast Cells as an Indicator of Wound Healing in the Soft Tissue of Pig Ears

Machmud, Edy; Ruslin, Muhammad; Waris, Rahmat Abd; Asse, Rustan Ambo; Qadafi, Andi Muamar; Achmad, Harun

doi:10.1590/pboci.2020.032

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…Sulfated polysaccharides from Chlorella vulgaris exhibited a capacity to prevent the accumulation and activity of free radicals and reactive chemical species, acting as protecting systems against these oxidative and radical stress agents [ 87 ]; in addition, peptides have been shown to reduce the matrix metalloproteinase-1 (MMP-1) expression in human skin cell fibroblasts, responsible for the breakdown of collagen [ 88 ]. The fact that a Chlorella vulgaris extract is able to stimulate collagen synthesis in the skin makes it suitable to be used in anti-aging cosmetics, as well as in wound-healing products [ 89 , 90 ].…”

Section: Efficacy Of Algae-containing Formulations On Sensitive Skinmentioning

confidence: 99%

Marine Ingredients for Sensitive Skin: Market Overview

et al. 2021

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Marine ingredients are a source of new chemical entities with biological action, which is the reason why they have gained relevance in the cosmetic industry. The facial care category is the most relevant in this industry, and within it, the sensitive skin segment occupies a prominent position. This work analyzed the use of marine ingredients in 88 facial cosmetics for sensitive skin from multinational brands, as well as their composition and the scientific evidence that supports their efficacy. Marine ingredients were used in 27% of the cosmetic products for sensitive skin and included the species Laminaria ochroleuca, Ascophyllum nodosum (brown macroalgae), Asparagopsis armata (red macroalgae), and Chlorella vulgaris (microalgae). Carotenoids, polysaccharides, and lipids are the chemical classes highlighted in these preparations. Two ingredients, namely the Ascophyllum nodosum extract and Asparagopsis armata extracts, present clinical evidence supporting their use for sensitive skin. Overall, marine ingredients used in cosmetics for sensitive skin are proposed to reduce skin inflammation and improve the barrier function. Marine-derived preparations constitute promising active ingredients for sensitive skin cosmetic products. Their in-depth study, focusing on the extracted metabolites, randomized placebo-controlled studies including volunteers with sensitive skin, and the use of extraction methods that are more profitable may provide a great opportunity for the cosmetic industry.

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Section: Efficacy Of Algae-containing Formulations On Sensitive Skinmentioning

confidence: 99%

Marine Ingredients for Sensitive Skin: Market Overview

et al. 2021

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Development and evaluation of drug delivery patch for topical wound healing application

et al. 2021

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Wound treatment remains a challenge to many clinicians because of the complexities of the wound healing process. With the astonishing progress of biomedical engineering during the past few decades, conventional drug delivery systems have been evolved into smart drug delivery systems with stimuli-responsive characteristics. The objective of this study was to develop and evaluate an electromechanically actuated drug dispensation device which can release active pharmaceutical compound in a controlled fashion. Additive manufacturing was employed to design and fabricate the device. Haptic technology was used to provide stimulation for drug release, and Cicatrin was used to evaluate the drug release patterns of device. Drug release study was comprised of in vitro drug release, static study, and the purpose of this study was to develop a compliance chart for different wound conditions. The effectiveness of shortlisted drug regimen from compliance chart was validated through microbial study and animal studies. The results of animal studies were compared with commercially available drug release systems. The results of drug release studies gave different dose regimens for different wound conditions. The effective dose regimen was able to create 1-cm-wide microbial zone of inhibitions. The wound healing rate of mice for commercially available release system for five consecutive days was 10%, 10%, 20%, 40% and 50% and for test device was 10%, 30%, 60%, 90% and 100%. Hence, the device proved its effectiveness and efficacy of dosage regimen for wound healing applications through in vitro, microbial and in vivo studies. In conclusion, this device proved to be an accurate and specific drug delivery system with improved medication and therapeutic outcomes for personalized medication.

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