Chemical constituents and nutritional health functions of Dendrobium nobile: a review

WANG, Guopan; Wang, Jianmei; DENG, Yidan; Qin, Lin; He, Yuqi; Tan, Daopeng

doi:10.1590/fst.84522

Cited by 10 publications

(8 citation statements)

References 45 publications

(15 reference statements)

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“…In recent years, the research and development of functional products made from herbs has attracted increasing attention (Ruiz-Cisneros et al, 2022;Wang et al, 2022a;Wang et al, 2022b;Yin et al, 2022). The genus Dendrobium contains approximately 1100 species, which is one of the largest genera in the family Orchidacea, and mainly distributed in southwestern Asia, Europe and Australia, such as China, Thailand, Myanmar and Vietnam (Yu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

et al. 2023

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Dendrobium nobile is a traditional Chinese medicine and functional food in China, with anti-aging, immunity-enhancing, glucose-lowering and lipid-lowering health functions. In recent years, the research value of D. nobile has attracted the attention of more and more experts and scholars. Today, phytochemical investigation of the stems of Dendrobium nobile Lindl., led to the isolation of five sesquiterpene glycosides, including dendromoniliside D (1), dendronobiloside A (2), dendronobiloside C (3), dendronobiloside D (4), dendroside G (5) and their α-amylase and α-glycosidase inhibitory activities were also investigated. Among them, dendromoniliside D (1), dendroside G (5) were first isolated from D. nobile. And dendronobiloside A (2) and dendronobiloside C (3) exhibited better inhibitory activity against α-glycosidases, respectively. In the case of α-amylase inhibition, dendroside G (5) has a relatively good effect. These results suggest that sesquiterpene glycosides of D. nobile have potential hypoglycemic activity and deserve further research and development.

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Section: Introductionmentioning

confidence: 99%

Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

et al. 2023

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“…Due to the crucial medicinal values of D. nobile stem in TCM, its phytochemistry and modern pharmacology have attracted increasing attention. Some review papers have summarized that the main bioactive constituents of D. nobile stem were alkaloids, sesquiterpenes, dibenzyls, phenanthrenes, and polysaccharides, and the important pharmacological effects include anti-tumor, anti-oxidation, anti-aging, anti-inflammation, improving immunity, anti-fatigue, neuroprotection, and protecting the liver and kidney ( He et al., 2020 ; Nie et al., 2020 ; Linghu et al., 2021 ; Wang et al., 2022 ). Among these constituents, alkaloids have caught researcher’s special concerns because it was the earliest identified classification of bioactive compounds in Dendrobium and responsible for numerous pharmacological effects ( Chen and Chen, 1935 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI

et al. 2023

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The stem of Dendrobium nobile Lindl. (Orchidaceae), called “Shihu” in traditional Chinese medicine, is a well-known medicinal and edible plant material in China. It is used as an antipyretic, analgesic, and tonic to nourish the stomach and Yin (i.e., to improve the production of body fluids). These therapeutic properties are attributed to its alkaloids, sesquiterpenoids, bibenzyls, fluorenones, and phenanthrenes. However, a comprehensive understanding of these metabolites and their spatial distribution in stems is lacking. In this study, ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was performed to obtain detailed metabolites information about D. nobile stems. Then, the spatial distributions of diverse metabolites, including alkaloids and sesquiterpenoids, were characterized and visualized by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-TOF-MSI). Based on the spatial and metabolic profiling data, sesquiterpene alkaloid dendrobine was chosen for the exhaustive study of a biosynthetic pathway in D. nobile. This is the first report on mass spectrometry imaging for Dendrobium species. As a result, critical bioactive metabolites such as 11 alkaloids, 10 sesquiterpenes, and 13 other metabolites were putatively identified and relatively quantified. The identified alkaloids were distributed in the parenchyma or vascular bundle, and sesquiterpenes were present in all regions of the stem with higher abundance in the vascular bundle and cuticle, or in the cuticle and epidermis. The biosynthetic pathway and accumulation pattern of dendrobine in D. nobile stem were also proposed. Our findings not only provided a critical methodology for the thorough understanding of physiological changes in metabolites and precise utilization of D. nobile stem, but also displayed an effective strategy for insight into the biosynthesis of bioactive metabolites in plants.

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“…Dendrobium devonianum Paxt., as a characteristic species of Dendrobium in Longling area of Yunnan Province, China, has good biological health effects (Deng et al, 2018;Wu et al, 2019;Fan et al, 2022;Wang et al, 2022). In China, like Dendrobium officinale Kimura et Migo (Wang et al, 2022;Li et al, 2021), Dendrobium devonianum is also a medicinal and food homologous plant, which was a Chinese medicinal material, and can also be used as a local specialty food or as a raw material for making other foods (Heussner & Bingle, 2015;Luo et al, 2021;Dong et al, 2016). The distribution of Dendrobium devonianum was mainly concentrated in the southeast to west of Yunnan, northwest Guangxi, southwest Guizhou (Wu et al, 2020), while the quality produced in Longling area was higher than that of Dendrobium officinale produced locally.…”

Section: Introductionmentioning

confidence: 99%

A simple method for distinguishing Dendrobium devonianum and Dendrobium officinale by ultra performance liquid chromatography-photo diode array detector

Lin

Chen

et al. 2023

Food Sci. Technol

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Using UPLC and PDA detector, the fingerprints of Dendrobium devonianum and Dendrobium officinale produced in the Longling area of Yunnan Province, China were obtained quickly and efficiently, and 26 common peaks in Dendrobium devonianum and Dendrobium officinale samples were obtained by automatic peak matching through the "Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System". The relative peak areas of the common peaks were analyzed by PCA using R, and the results showed that Dendrobium devonianum and Dendrobium officinale could be well distinguished by PCA, which was consistent with the analysis results of OPLS-DA. The results fully demonstrate that Dendrobium devonianum and Dendrobium officinale grown in the same area can be effectively distinguished by using the method of common peaks combined with stoichiometry. The VIP value of the 13 common peaks is greater than 1.0, which has a significant contribution to the difference and it was differential marker in Dendrobium devonianum and Dendrobium officinale. At the same time, normal-phase silica gel column chromatography was used to separate and purify the compounds that are related to the common peaks, and a total of 7 compounds were identified, among which eupatolide and isoschaftoside belong to differential markers and characteristic compounds in Dendrobium devonianum and Dendrobium officinale, which have good biological health care activity. The successful identification of Dendrobium devonianum and Dendrobium officinale in Longling area of Yunnan Province and the discovery of related differential markers play an important role in the further research and development of Dendrobium devonianum as a new food raw material and its products.

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Chemical constituents and nutritional health functions of Dendrobium nobile: a review

Cited by 10 publications

References 45 publications

Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

Metabolic profiling, in-situ spatial distribution, and biosynthetic pathway of functional metabolites in Dendrobium nobile stem revealed by combining UPLC-QTOF-MS with MALDI-TOF-MSI

A simple method for distinguishing Dendrobium devonianum and Dendrobium officinale by ultra performance liquid chromatography-photo diode array detector

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