Anti-neuroinflammatory activity of Humulus japonicus extract and its active compound luteolin on lipopolysaccharide-induced inflammatory response in SIM-A9 microglia via NF-κB and MAPK signaling pathways

Feng, Wenhuan; Cho, Byoung Ok; Shin, Jae Young; Hao, Suping; Jang, Seon Il

doi:10.1590/fst.78621

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…D. Li (2015) supplemented HS granules into the diet of mice with chronic bronchitis and found a reduction of cough symptoms and the amelioration of pathological damage in lung tissue. F. Wang et al (2021) investigated the anti‐inflammatory impacts of HS ethanol extract on lipopolysaccharide‐stimulated microglia. Results showed that HS ethanol extract inhibited the generation of interleukin‐1β, tumour necrosis factor‐α, nitric oxide, interleukin‐6, decreased cytoplasmic mitogen‐activated protein kinase levels and increased nuclear factor erythroid 2–related factor 2 levels in the cytoplasm and nucleus.…”

Section: Application Of Hs and Its Productsmentioning

confidence: 99%

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Application potential of Humulus Scandens in livestock husbandry

Dang

Wang

et al. 2023

Animal Physiology Nutrition

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On the background of antibiotic‐free livestock husbandry, animal nutritionists are trying to find alternatives to antibiotics. Many herbs have been developed for animal diets to replace antibiotics. Humulus Scandens (HS) is also known as Humulus japonicus and Japanese hop in English, lü Cao (葎草) in Mandarin Chinese and kanamugura (カナムグラ) in Japanese. It is a traditional Chinese medicine with good environmental adaptability. It can grow rapidly and cover any area. Its high yield, strong vitality and medical value allow its potential to be used as an exogenous additive for animal diets to replace antibiotics. However, the knowledge about this herb is limited at present. This manuscript reviewed the processing method of HS and its application in livestock husbandry in order to provide references for its application.

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Section: Application Of Hs and Its Productsmentioning

confidence: 99%

“…supplemented HS granules into the diet of mice with chronic bronchitis and found a reduction of cough symptoms and the amelioration of pathological damage in lung tissue. F Wang et al (2021). investigated the anti-inflammatory impacts of HS ethanol extract on lipopolysaccharide-stimulated microglia.…”

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confidence: 99%

Application potential of Humulus Scandens in livestock husbandry

Dang

Wang

et al. 2023

Animal Physiology Nutrition

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“…Chemical analysis of the extract revealed among the most abundant components luteolin-7-O-glucoside and apigenin-7-O-glucoside, molecules known to significantly inhibit the enzymatic activity of monoamine oxidase B, which plays an important role in the catabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (such as dopamine) [74]. The same extract was further tested to assess its anti-inflammatory impact on lipopolysaccharide-stimulated SIM-A9 cells, showing its own and luteolin's ability to inhibit, among all, the generation of interleukin-1β, tumour necrosis factor-α, nitric oxide, and interleukin-6 [75]. Recently, Kang et al (2022) demonstrated that a water extract of HJ, when orally administered (500 mg/kg/day for 3 weeks), significantly decreased β amyloid plaque deposition in the cerebral cortex and hippocampus of Alzheimer's disease (AD) mice models, also protecting against AD-related memory impairments via enhancing the cholinergic system [76].…”

Section: Humulus Japonicus/humulus Scandensmentioning

confidence: 99%

An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Carbone

Gervasi

2022

Plants

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The medicinal potential of hop (Humulus lupulus L.) is widely cited in ancient literature and is also allowed in several official pharmacopoeias for the treatment of a variety of ailments, mainly related to anxiety states. This is due to the plethora of phytoconstituents (e.g., bitter acids, polyphenols, prenyl flavonoids) present in the female inflorescences, commonly known as cones or strobili, endowed with anti-inflammatory, antioxidant, antimicrobial, and phytoestrogen activities. Hop has recently attracted the interest of the scientific community due to the presence of xanthohumol, whose strong anti-cancer activity against various types of cancer cells has been well documented, and for the presence of 8-prenyl naringenin, the most potent known phytoestrogen. Studies in the literature have also shown that hop compounds can hinder numerous signalling pathways, including ERK1/2 phosphorylation, regulation of AP-1 activity, PI3K-Akt, and nuclear factor NF-κB, which are the main targets of the antiproliferative action of bitter acids and prenylflavonoids. In light of these considerations, the aim of this review was to provide an up-to-date overview of the main biologically active compounds found in hops, as well as their in vitro and in vivo applications for human health and disease prevention. To this end, a quantitative literature analysis approach was used, using VOSviewer software to extract and process Scopus bibliometric data. In addition, data on the pharmacokinetics of bioactive hop compounds and clinical studies in the literature were analysed. To make the information more complete, studies on the beneficial properties of the other two species belonging to the genus Humulus, H. japonicus and H. yunnanensis, were also reviewed for the first time.

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“…LPS is an endotoxin inducing inflammation and is used to create neurodegenerative in vitro models (Oh et al, 2021). LPS induces microglial cells activate inflammation through AKT/STAT, NF-κB, and MAPKs signaling pathways, these cells generate too many inflammatory mediators for instance NO and PGE 2 , at the same time pro-inflammatory cytokines TNF-α, IL-6, and IL-1 (Wang et al, 2021a;Wang et al, 2021b;Jung et al, 2009;Ryu et al, 2019;Zhao et al, 2019). Thus, it is significant to regulate MAPK, NF-κB, and the AKT/STAT pathways for treating neuroinflammatory diseases and controlling microglial activation can be used to treat apoptosis and inflammation in neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Zingiber officinale attenuates neuroinflammation in LPS-stimulated mouse microglia by AKT/STAT3, MAPK, and NF-κB signaling

et al. 2022

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To explore the protective activity of ginger (Zingiber officinale) root ethanol extract (GRE) on the neuroinflammation induced by lipopolysaccharide in microglial cells. Ginger has been investigated as a neuroprotective and anti-aging agent. Nevertheless, ginger extract attenuates neuroinflammation in microglia have not been discovered in depth. The results showed that GRE had high total phenolic and (55.63 ± 0.16 mg GAE/g) and total flavonoid content (4.33 ± 0.17 mg QUE/g), and antioxidant activity. GRE inhibited the release of cytokines and inflammatory mediators including COX-2, PGE 2 , Nitric oxide, interleukin-6, TNF-α, and iNOS. GRE ameliorated microglia-mediated neuronal insults via upregulating the expression of Bax and reducing the expression of Bcl-2. GRE suppressed NF-κB and AKT/STAT3, and the MAPK pathway in the neuroinflammatory response. In conclusions, GRE positively affected anti-neuroinflammatory and neuroprotective activity without serious side effects, which might be used as a functional food additive and/or therapeutic material for the management and prevention of neurodegenerative diseases.

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Anti-neuroinflammatory activity of Humulus japonicus extract and its active compound luteolin on lipopolysaccharide-induced inflammatory response in SIM-A9 microglia via NF-κB and MAPK signaling pathways

Cited by 6 publications

References 35 publications

Application potential of Humulus Scandens in livestock husbandry

Application potential of Humulus Scandens in livestock husbandry

An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Zingiber officinale attenuates neuroinflammation in LPS-stimulated mouse microglia by AKT/STAT3, MAPK, and NF-κB signaling

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