Main components of ethyl acetate extract of Chimonanthus salicifolius and its effects on intestinal mucositis in mice induced by 5-fluorouracil

Han, Wen; Lei, Weimin; Hou, Jing; Ke, Leqin

doi:10.1590/fst.55720

Cited by 4 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, the alcohol extract proved to have broad inhibitory activity against most pathogenic bacteria such as Escherichia coli and Staphylococcus aureus . Ethyl acetate extract could alleviate intestinal mucositis in mice induced by 5‐fluorouracil, which may be related to the anti‐inflammatory and antioxidant effects (Wen et al, 2021). Although bacteriostatic properties of C. salicifolius have been reported, the research was rarely related to effect of bacteriostatic function on intestinal microecology.…”

Section: Resultsmentioning

confidence: 99%

“…The mice (BALB/c mice, male, 7 weeks old, inbred strain) were randomly divided into five groups ( n = 10 for each group) and classified into a normal control group (control), DSS‐induced model group (2.5%, w/v, 36–50 k Da), 10 g/kg CSE group, LGG (3.0 × 10 9 CFU/mL), and 5‐ASA (100 mg/kg) group (Murray et al, 2020; Wen et al, 2021). Apart from the control group, DSS solution (2.5%, w/v) was prepared for drinking water to the mice daily in the other four groups for 2 weeks, while the mice in the control group were given a saline solution.…”

Section: Methodsmentioning

confidence: 99%

Section: Heliobacteriaceae Was Usually Classified Into Firmicutes Andmentioning

confidence: 99%

See 2 more Smart Citations

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Chen

2023

Food Science & Nutrition

View full text Add to dashboard Cite

Ulcerative colitis is a chronic and recurrent gastrointestinal intestinal disease accompanied by inflammatory disorders, immunologic inadequacy, and intestinal flora dysbiosis, and current therapeutic pharmaceuticals have limited side effects. In this study, we revealed the extraction method of Chimonanthus salicifolius, analyzed the main component, compared the effect of its extract, Lactobacillus, and conventional drugs with different properties on DSS (dextran sodium sulfate)‐induced colitis, and indicated extract regulatory properties of inestinal flora. A colitis model was established on experimental design, and BALB/c mice (male, 7 weeks old) were randomly assigned to five groups (n = 10): control, DSS model, Chimonanthus salicifolius extract (CSE), Lactobacillus rhamnosus GG (LGG), and 5‐aminosalicylic acid (5‐ASA) groups. The three treatments could alleviate the symptoms and remit inflammation induced by DSS, in which CSE and LGG groups could both decrease the proinflammatory cytokine IL‐6, IL‐8, and TNF‐α levels and increase anti‐inflammatory cytokines IL‐10 and TGF‐β. The CSE intervention significantly promoted the higher production of butyric acid than LGG and 5‐ASA groups (p < .05) after DSS challenge. Analysis of intestinal flora showed that CSE administration remarkably decreased the relative abundance of pathogenic bacteria Heliobacteriaceae and Peptococcaceae and exhibited higher abundance of Lactobacillaceae and Bifidobacterium than LGG in intestinal tract of mice (p < .05). These findings indicated that Chimonanthus salicifolius extract may have been beneficial for preventing and treating colitis.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Heliobacteriaceae Was Usually Classified Into Firmicutes Andmentioning

confidence: 99%

See 1 more Smart Citation

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Chen

2023

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Intestinal protective effects of essential oil from Chimonanthus salicifolius linked to Mfn2-tethered mitochondria-endoplasmic reticulum connection

Yang,

Li,

Chen

et al. 2024

Journal of Functional Foods

View full text Add to dashboard Cite

Nonpharmacological approaches for improving gut resilience to chemotherapy

Bullard¹,

McDonald²,

Cardaci³

et al. 2022

Current Opinion in Supportive &Amp; Palliative Care

View full text Add to dashboard Cite

Purpose of reviewMucositis of the gastrointestinal tract is a debilitating side effect of chemotherapy that negatively influences treatment tolerance and patient life quality. This review will evaluate the recent literature on nonpharmacological strategies that have the potential to improve chemotherapy-induced mucositis (CIM).Recent findingsAlternatives to pharmacological approaches have shown great promise in preventing CIM. Natural products, including curcumin, ginseng, quercetin, and patchouli all show potential in mitigating CIM. In addition, dietary patterns, such as the elemental diet, high fiber diet, and diets high in amino acids have documented benefits in preventing CIM. Perhaps the greatest advancement coming to this arena in recent years is in the field of probiotics. Indeed, research on single species as well as probiotic mixtures show potential in reducing CIM insofar as probiotics are now being suggested for treatment of CIM by governing bodies. Although behavioral interventions including psychological interventions and exercise interventions have shown promise in reducing cancer therapy-related side effects, more work in this domain is warranted and particularly in the context of CIM.SummaryAlternatives to pharmacological approaches show great potential for use in prevention and treatment of CIM and should be further developed for use in the clinic.

show abstract

Main components of ethyl acetate extract of Chimonanthus salicifolius and its effects on intestinal mucositis in mice induced by 5-fluorouracil

Cited by 4 publications

References 23 publications

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Chimonanthus salicifolius extract alleviates DSS‐induced colitis and regulates gut microbiota in mice

Intestinal protective effects of essential oil from Chimonanthus salicifolius linked to Mfn2-tethered mitochondria-endoplasmic reticulum connection

Nonpharmacological approaches for improving gut resilience to chemotherapy

Contact Info

Product

Resources

About