CLDN18-ARHGAP26 function in gastric cancer and be a new therapeutic target by ABCG2 and ABCB1 pathway

Li, Jing; Zheng, Xiu Ting; Jia, Jianguang; Xie, Bingteng; Zhang, Chen-Song; Wang, Hu; Li, Hongbo; Ma, Jiachi

doi:10.1590/fst.54821

Cited by 4 publications

(5 citation statements)

References 28 publications

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“…Untreatment: U87 cells without sample treatment; Geniposide: U87 cells treated with 100 μg/mL geniposide solution; LC-NBRC101979: U87 cells treated with 10 6 CFU/mL LC-NBRC101979 solution; Geniposide + LC-NBRC101979: U87 cells treated with 100 μg/mL geniposide and 10 6 CFU/mL LC-NBRC101979 solution. caspase family, oncogenes like c-myc, and the tumor suppressor gene p53, are relatively conservative among species (Lee et al, 2005;Li et al, 2022). Most anticancer drugs cause apoptosis by activating corresponding apoptosis pathways, such as those of the Bcl-2 family proteins, which play an important role in cell death and are reflected by a rise in the Bax/Bcl-2 ratio.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus casei enhances the apoptosis inducing effect of geniposide on U87 human glioma cells in vitro

et al. 2023

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The goal of this work was to clarify the mechanism of action of Lactobacillus casei on genipin in triggering glioma apoptosis. DPPH and ABTS free radicals could be successfully eliminated by geniposide, LC-NBRC101979 (Lactobacillus casei), and geniposide + LC-NBRC101979. Geniposide and LC-NBRC101979 had effects that were stronger when combined than when taken alone. Geniposide, LC-NBRC101979, and Geniposide + LC-NBRC101979 did not have any detrimental effects on healthy epithelial cells HBE, but they greatly decreased the growth of U87 glioma cells, according to cell studies. Additionally, the combination of geniposide and LC-NBRC101979 had a stronger inhibitory impact than either drug alone. Results from qPCR revealed that in U87 cells, geniposide, LC-NBRC101979, and eniposide + LC-NBRC101979 could up-regulate caspase-3, COX-2, p53, c-myc, p21 mRNA expression and down-regulate Bcl-2, NF-κB expression. According to the results of the study on the effects of oxidative stress on cells, geniposide, LC-NBRC101979, and geniposide combined with LC-NBRC101979 can decrease the levels of MDA, LDH, and NO in normally damaged epithelial cells caused by oxidative stress and increase the levels of CAT, SOD, GSH-Px, and T-AOC. According to HPLC data, LC-NBRC101979 was able to convert the majority of geniposide into geniposide. It is clear that LC-NBRC101979 may enhance geniposide's inhibitory impact on glioma.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus casei enhances the apoptosis inducing effect of geniposide on U87 human glioma cells in vitro

et al. 2023

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“…It has been reported in the literature that Helicobacter pylori causes gastric cancer, which is more likely to be related to hypergastrinemia (Waldum & Fossmark, 2021). In addition, some other related influencing factors include people's smoking, alcoholism, heavy oil and heavy salt eating habits in daily life, as well as the expression of genetic mutations (Li et al, 2022b). Traditional Chinese medicine believes that the occurrence of gastric cancer is the result of the combined action of multiple factors, and the deficiency of righteousness and the disorder of the viscera are the internal causes of the disease.…”

Section: Discussionmentioning

confidence: 99%

Effects of Jiawei Huangqi Guizhi Decoction on the expression of GAS, MTL, GC, and TGF-β3 signaling pathways in CAG rats

CHEN

Cao

et al. 2023

Food Sci. Technol

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To study the effect of Jiawei Huangqi Guizhi Decoction on gastrointestinal hormones and TGF-β3 signal pathways in rats with chronic atrophic gastritis (CAG). The model was created by methylnitrosoguanidine (MNNG) comprehensive method. After successful modeling, it was divided into three groups: model group (MC group), frolic acid group (AC group), modified Huangqi Guizhi Decoction high dose group (HH group), modified Huangqi Guizhi Decoction middle dose group (HM group), and modified Huangqi Guizhi Decoction low dose group (HL group). Gastric pathology was observed by HE staining. The levels of gastrin (GAS) and motilin (MTL) in rat serum were detected by ELISA assay. After HE staining, the histopathological sections were analyzed. Inflammatory factors infiltration and disorder of mucosal epithelial cells were found in the model group, which were improved to some extent after administration. According to the pathological chart analysis and score of rats in each group, compared with the model group, the gastric tissue damage of rats in each administration group has been improved in different degrees, among which the pathological scores of HH and HM groups were lower, and the corresponding damage degree was smaller. According to the test results of ELISA, Jiawei Huangqi Guizhi Decoction could reduce the contents of GAS, TGF-β3, and increase MTL abundance in the serum of rats, thus accelerating the apoptosis of tumor cells and inhibiting cancer. Jiawei Huangqi Guizhi Decoction played a positive role in preventing the occurrence of gastric cancer through reducing the concentrations of GAS and TGF-β3 in serum, and increasing the concentration of MLT in serum. This results provided a new treatment idea for CAG.

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“…Gastric cancer is a malignant tumor with a high incidence rate (Jiao et al, 2022;Li et al, 2022). Symptoms are difficult to detect in the early stages and gastric cancer is therefore usually diagnosed in the advanced or metastatic stage.…”

Section: Introductionmentioning

confidence: 99%

Effect of white lion goose serum on gastric cancer cells

CHAOYANG,

JINGJING,

JINGJING

et al. 2024

Food Sci. Technol (Campinas)

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Goose blood is rich in nutrients and a variety of bioactive ingredients, it have the effect of prevent cancer in humans, but the mechanism is not clear. So, we studied the effects of White Lion Goose serum on gastric cancer cells. The in vitro cell proliferation of human gastric cancer cells (AGS) was analyzed by a CCK-8 assay; cell morphology was observed using an inverted microscope; the wound healing ability of cells was detected by a scratch and abrasion test; and cell cycle distribution and cell apoptosis were detected by flow cytometry. The results showed that with increased concentration and prolonged incubation time, the serum of White Lion Goose reduced the viability, changed the morphology, and reduced the migration rate of gastric cancer cells. The proportion of gastric cancer cells in the early (G0/G1 phase) and late (G2/M phase) stages of DNA synthesis was decreased, the proportion of cells in stationary phase (S phase) was increased, and the apoptosis rate was increased accompanied by a decrease in the number of viable cells. The serum of White Lion Goose had a significant inhibitory effect on the proliferation of human gastric cancer cells, changed the distribution of the cell cycle and induced apoptosis in both a dose- and time-dependent manner. The results showed that the blood of the White Lion Goose contained highly bioactive components, which had an obvious inhibitory effect on the proliferation of gastric cancer cells cultured in vitro.

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CLDN18-ARHGAP26 function in gastric cancer and be a new therapeutic target by ABCG2 and ABCB1 pathway

Cited by 4 publications

References 28 publications

Lactobacillus casei enhances the apoptosis inducing effect of geniposide on U87 human glioma cells in vitro

Lactobacillus casei enhances the apoptosis inducing effect of geniposide on U87 human glioma cells in vitro

Effects of Jiawei Huangqi Guizhi Decoction on the expression of GAS, MTL, GC, and TGF-β3 signaling pathways in CAG rats

Effect of white lion goose serum on gastric cancer cells

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