Effect of Mir-299-3p on the biological function of lung adenocarcinoma cell H1299 through targeting PTPRD

Yuan, Yuan; Xiao-quan, Chen; Yuan, Bin; Hu, Yuqin

doi:10.1590/fst.43321

Food Sci. Technol

2022

DOI: 10.1590/fst.43321

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Effect of Mir-299-3p on the biological function of lung adenocarcinoma cell H1299 through targeting PTPRD

Yuan Yuan¹,

Chen Xiao-quan²,

Bin Yuan³

et al.

Abstract: Methods CCK8 cell proliferation experimentPulmonary adenocarcinoma cells H1299 were obtained, and the cells were transfected with Mir-299-3p, Mir-299-3p inhibitor and NC respectively. After 6 h of transfection, the medium was replaced with 1640 complete medium. The CCK8 method was used to measure cell proliferation, and the absorbance of each well at 450 nm was measured with a microplate reader.

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The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer

Smok-Kalwat

Mertowska

Mertowski

et al. 2023

IJMS

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Lung cancer is a disease that in recent years has become one of the greatest threats to modern society. Every year there are more and more new cases and the percentage of deaths caused by this type of cancer increases. Despite many studies, scientists are still looking for answers regarding the mechanisms of lung cancer development and progression, with particular emphasis on the role of the immune system. The aim of this literature review was to present the importance of disorders of the immune system and the accompanying changes at the level of cell signaling in the pathogenesis of lung cancer. The collected results showed that in the process of immunopathogenesis of almost all subtypes of lung cancer, changes in the tumor microenvironment, deregulation of immune checkpoints and abnormalities in cell signaling pathways are involved, which contribute to the multistage and multifaceted carcinogenesis of this type of cancer. We, therefore, suggest that in future studies, researchers should focus on a detailed analysis of tumor microenvironmental immune checkpoints, and to validate their validity, perform genetic polymorphism analyses in a wide range of patients and healthy individuals to determine the genetic susceptibility to lung cancer development. In addition, further research related to the analysis of the tumor microenvironment; immune system disorders, with a particular emphasis on immunological checkpoints and genetic differences may contribute to the development of new personalized therapies that improve the prognosis of patients.

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The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer

Smok-Kalwat

Mertowska

Mertowski

et al. 2023

IJMS

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show abstract

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Effect of Mir-299-3p on the biological function of lung adenocarcinoma cell H1299 through targeting PTPRD

Cited by 1 publication

References 14 publications

The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer

The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer

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