Effect of functional food raw material Peucedanum praeruptorum Dunn: a research update

Abstract

Cardiomyocytes of guinea pigs were treated with a dose of 5 μmol•L -1 . The antiarrhythmic effect is very rapid. Treatment with a praeruptorin A (Pd-Ia), the active component of P. praeruptorum Dunn A at a dose of 50 μmol•L -1 enhanced the antiarrhythmic effect. Treatment with P. praeruptorum Dunn A shortened the action potential durations APD30, APD50 and APD100 of guinea pig cardiomyocytes (Feng et al., 1998). Pd-Ia also significantly shortened action potential amplitude (APA) of guinea pig ventricular myocytes. Exposure to a dose of 5 μmol•L -1 resulted in an increase in action potential from normal (90.82 ± 3.07) mV to (87.2 ± 3.51) mV. When the dosage was increased to 50 μmol•L -1 , the shortening effect was significant (85.41 ± 3.44 mV) and dose-dependent. These results suggest that PD-IA has an anti-arrhythmic effect, and the mechanism may be mediated via Ca 2+ . The internal circulation channel is blocked. PD-IA reduces the heart weight-to-body weight ratio and also decreases the activity of serum creatine kinase and other enzymes via mechanisms similar to inhibition of calcium influx (Lin et al., 2007). In addition, PD-IA promotes the expression of nestin, which is significantly enhanced in both myocardial ischemic and infarcted cells. Therefore, it is believed that nestin expression is related to the regeneration and repair of myocardial cells to a certain extent.Functional foods are some industrial processed or natural foods (Figure 1). When regularly consumed at an effective level in a variety of diets, they not only provide basic nutrition to the human body, but also have a potential positive impact on human health (Granato et al., 2020). Now common functional foods include probiotics (Long et al., 2022), active factors from natural sources (Khan et al., 2021;Jiang et al., 2021), foods composed of clear compound nutrients (Califa-Estwick et al., 2021;ur Rehman et al., 2021), etc. As a new source of food from a research perspective, P. praeruptorum Dunn may play a role in

Differences of Chemical Constituents and Pharmacological Activities of Traditional Herbs Before and After Honey-Frying

“…42 Moreover, Zi Hua Qian Hu was known for antitussive and expectorant effects, which were enhanced after honey-frying and had been demonstrated in in vivo test. 43 Radix et Rhizoma Asteris: Tatarinow's aster, Zi Wan (Chinese: 紫菀), Tử uye ̂n (Vietnamese)…”

“…42 Moreover, Zi Hua Qian Hu was known for antitussive and expectorant effects, which were enhanced after honey-frying and had been demonstrated in in vivo test. 43…”