2022
DOI: 10.1590/fst.36820
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MicroR-146 protects against rat ischemia-reperfusion injury by targeting NF-κB-mediated PI3K/AKT/mTOR signaling pathway

Abstract: plays crucial roles in attenuating nerve injury during cerebral ischemia-reperfusion (I/R) injury. The purpose of this study was to investigate the neuroprotective effect of miR-146 against cerebral I/R injury. Rat model of cerebral I/R injury was established using 4-vessel occlusion and reperfusion. In this study, miR-146 expression was significantly decreased in neurons in cerebral I/R injury rat compared to sham group. In addition, miR-146+/+ significantly decreased inflammatory cytokines, oxidative stress,… Show more

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Cited by 5 publications
(4 citation statements)
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“…At present, the research on methane efficacy after TBI is not very extensive, it's essential to find out the probable mechanisms of its protective effect. Potts et al, 2006 andWang et al, 2021a suggested to regard inflammation, oxidative injury, and ironmediated damage as potential therapeutic targets of brain injury. Based on previously reported biological characteristics of methane (Song et al, 2015;Wang et al, 2017b;Yao et al, 2017), we supposed that methane protects brain via anti-inflammation, anti-oxidant and anti-apoptotic mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…At present, the research on methane efficacy after TBI is not very extensive, it's essential to find out the probable mechanisms of its protective effect. Potts et al, 2006 andWang et al, 2021a suggested to regard inflammation, oxidative injury, and ironmediated damage as potential therapeutic targets of brain injury. Based on previously reported biological characteristics of methane (Song et al, 2015;Wang et al, 2017b;Yao et al, 2017), we supposed that methane protects brain via anti-inflammation, anti-oxidant and anti-apoptotic mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…The PI3K-Akt pathway has intrinsic effects on the proliferation of cancer cells (Wang et al, 2022), inhibits PI3Kδ signaling through BCR and other pathways, promotes FL cell death, and restores FL cell dependence on Bcl-2 anti-apoptotic protein (McCubrey et al, 2006). Bcl-2 family proteins are apoptosis-regulating proteins and play a key role in apoptosis (Volkmann et al, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…LPS is an endotoxin inducing inflammation and is used to create neurodegenerative in vitro models (Oh et al, 2021). LPS induces microglial cells activate inflammation through AKT/STAT, NF-κB, and MAPKs signaling pathways, these cells generate too many inflammatory mediators for instance NO and PGE 2 , at the same time pro-inflammatory cytokines TNF-α, IL-6, and IL-1 (Wang et al, 2021a;Wang et al, 2021b;Jung et al, 2009;Ryu et al, 2019;Zhao et al, 2019). Thus, it is significant to regulate MAPK, NF-κB, and the AKT/STAT pathways for treating neuroinflammatory diseases and controlling microglial activation can be used to treat apoptosis and inflammation in neurodegenerative diseases.…”
Section: Introductionmentioning
confidence: 99%