Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study

Zhang, Hongqi; Wang, Wenling; Zhang, Ruyi; Dong, Hongmin; Wang, Gang; Chen, Weiwei; Li, Guodong

doi:10.1590/fst.36320

Cited by 3 publications

(6 citation statements)

References 19 publications

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“…A specific PNI cut‐off value that can be used in all diseases has not yet been specified. However, in various studies on malignancies in the literature, low PNI has been reported to be associated with poor prognosis in different cancer types 24 , 25 , 26 and different cut‐off values for PNI in different diseases have been reported. 7 , 27 , 28 Wang et al found the PNI cut‐off value associated with the clinical severity of COVID‐19 to be <43, while Hu et al found it to be <49.…”

Section: Discussionmentioning

confidence: 99%

Can prognostic nutritional index predict mortality in intensive care patients with COVID‐19?

et al. 2021

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Objectives PNI is a calculated parameter using the albumin and the lymphocyte count from the CBC, which demonstrates the immunological and nutritional status of the patient. The aim of this study is to show the relationship between PNI and mortality in COVID‐19 patients and to reveal a PNI cut‐off value for mortality. Materials and Methods Data of 690 PCR positive COVID‐19 ICU patients were recorded. COVID‐19 ICU patients were divided into two groups; the first group consisted of survivors, while the second group consisted of patients who died in the ICU. Patients were also evaluated in two groups according to the PNI cut‐off value that predicted mortality (PNI ≤ 42.00, PNI ≥ 43) and were compared in terms of demographics, laboratory parameters, clinical findings and mortality rates. Results When 690 COVID‐19 patients were divided into two groups as survivors (50.6%) and deceased (49.4%) in intensive care, PNI value was significantly lower in the deceased group compared to the surviving group (P < .001). The PNI cut‐off value predicting mortality was determined as ≤42. Patients were classified into two groups according to the PNI cut‐off value. PNI ≤42 was determined as an independent risk factor for mortality (OR:2.9 P < .001). AUC values for PNI, albumin, and lymphocyte were 0.628, 0.612, and 0.590, respectively; P < .001 for all. Conclusion PNI is an inexpensive method that can be easily calculated on the basis of routine laboratory parameters. We believe that the PNI value of COVID‐19 patients on admission to the ICU may be an independent factor to predict mortality.

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Section: Discussionmentioning

confidence: 99%

Can prognostic nutritional index predict mortality in intensive care patients with COVID‐19?

et al. 2021

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“…64 A margem proximal mínima da ressecção deve ser de 5cm. 8 Quanto a dissecção linfonodal, além de possibilitar um adequado estadiamento do câncer reto, está associada ao controle local e à distância da doença, sendo a recomendação atual de ressecção de 12 ou mais linfonodos. 65…”

Section: Tratamento Cirúrgico Do Câncer De Retounclassified

“…7 No câncer colorretal especificamente, a incidência da desnutrição chega a 31%. 8 O prognóstico do câncer é determinado não só por características relacionadas ao tumor, mas também por aspectos nutricionais e imunológicos, conforme mostram alguns estudos. 120 Não obstante, frequentemente os fatores prognósticos mais utilizados são os que se correlacionam diretamente as características do tumor, como as morfológicas e genômicas, por exemplo, enquanto os estados nutricional e imunológico são desprezados.…”

Section: íNdice Prognóstico Nutricionalunclassified

“…120 O IPN foi criado em 1984, inicialmente para avaliar o status nutricional de pacientes cirúrgicos, e, posteriormente foi observado sua correlação como fator prognóstico em alguns tipos de câncer. 8,120 O cálculo do índice prognostico nutricional se dá através da seguinte fórmula: IPN = (10 x albumina sérica [g/dl]) + 0,005 x linfócitos/μL). 144 A albumina é um marcador importante do status nutricional, assim como os linfócitos são importantes marcadores do funcionamento do sistema imunológico.…”

Section: íNdice Prognóstico Nutricionalunclassified

“…7 O valor de corte do índice prognóstico nutricional não é padronizado na literatura, alguns estudos usam valores de corte empíricos variando entre 45 e 46, enquanto outros utilizam a mediana como valor de corte entre 45 e 49. 8 Um estudo retrospectivo contendo 365 pacientes com câncer colorretal ressecado, evidenciou que o IPN foi uma ferramenta prognóstica independente para sobrevida e complicações pós-operatórias. 145 Ainda, nesse estudo, foi observado que o índice prognóstico nutricional teve valor prognóstico semelhante ao do TNM pósoperatório e ao nível de CEA.…”

Section: íNdice Prognóstico Nutricionalunclassified

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Avaliação do índice prognóstico nutricional em pacientes com diagnóstico de câncer de reto não metastático acompanhados no hospital das clínicas da UNICAMP no período entre os anos 2000 a 2016

Cristina Ribeiro Silva

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The prognostic value of immune-nutritional status in metastatic colorectal cancer: Prognostic Nutritional Index (PNI)

Keskinkilic,

Semiz,

Ataca

et al. 2024

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Backround and purpose A low Prognostic Nutritional Index (PNI) value, which reflects immune nutrition and inflammation around the tumor, is associated with an unfavorable prognosis, and it was aimed to reveal its prognostic value in metastatic colorectal cancer (CRC). Methods In our retrospective cross-sectional study, patients with a diagnosis of metastatic colorectal disease without active infection, between January 2010 and December 2016 were included. The PNI values at the time of diagnosis were calculated according to the formula (10 × serum albumin (g/dL)) + (0.005 × total lymphocyte value). Results The mean PNI value of 253 patients included in the study was 46.6. While 53.75% (n = 136) of the patients had a PNI value of 46.6 and above, 46.25% (n = 117) had a PNI value below 46.6. The overall survival (OS) of the group with a PNI of 46.6 and above was statistically significantly longer (53.06 months vs 38.80 months, p = 0.039). The PFS duration of the group with PNI below 46.6 was 25.66 months, while the PFS duration of the group with PNI above 46.6 was not reached (p = 0.265). Conclusion PNI is a simple and inexpensive index that evaluates the immunonutritional status, and it is a prognostic marker that can be easily used in patients with metastatic colorectal cancer as in other cancer types.

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Comparison of the prognostic value of prognostic nutritional index in colorectal cancer deaths:a retrospective cohort study

Cited by 3 publications

References 19 publications

Can prognostic nutritional index predict mortality in intensive care patients with COVID‐19?

Can prognostic nutritional index predict mortality in intensive care patients with COVID‐19?

Avaliação do índice prognóstico nutricional em pacientes com diagnóstico de câncer de reto não metastático acompanhados no hospital das clínicas da UNICAMP no período entre os anos 2000 a 2016

The prognostic value of immune-nutritional status in metastatic colorectal cancer: Prognostic Nutritional Index (PNI)

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