The composition, pharmacological and economic importance of essential oil of Litsea cubeba (Lour.) Pers

Sivamaruthi, Bhagavathi Sundaram; Kesika, Periyanaina; Chaiyasut, Chaiyavat

doi:10.1590/fst.35720

Cited by 5 publications

(5 citation statements)

References 39 publications

(30 reference statements)

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“…is an aromatic herb that is widely distributed in Southern China, Japan, Southern Asia and Southeast Asia [42,46,83]. The plant is valued for the sweetscented, citral-rich essential oil produced from its fruits, which has economic importance in the pharmacy, cosmetics, perfumery, cookery and insecticide industries [83,84]. The fresh fruits are edible and are often used as a spice, while the fruits and seeds are commonly used as condiments [48].…”

Section: % Ethanolic Leaf Extractmentioning

confidence: 99%

The Analgesic Potential of Litsea Species: A Systematic Review

Goh,

Samsul,

Mohaimin

et al. 2024

Molecules

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Various plant species from the Litsea genus have been claimed to be beneficial for pain relief. The PRISMA approach was adopted to identify studies that reported analgesic properties of plants from the Litsea genus. Out of 450 records returned, 19 primary studies revealed the analgesic potential of nine Litsea species including (1) Litsea cubeba, (2) Litsea elliptibacea, (3) Litsea japonica, (4) Litsea glutinosa, (5) Litsea glaucescens, (6) Litsea guatemalensis, (7) Litsea lancifolia, (8) Litsea liyuyingi and (9) Litsea monopetala. Six of the species, 1, 3, 4, 7, 8 and 9, demonstrated peripheral antinociceptive properties as they inhibited acetic-acid-induced writhing in animal models. Species 1, 3, 4, 8 and 9 further showed effects via the central analgesic route at the spinal level by increasing the latencies of heat stimulated-nocifensive responses in the tail flick assay. The hot plate assay also revealed the efficacies of 4 and 9 at the supraspinal level. Species 6 was reported to ameliorate hyperalgesia induced via partial sciatic nerve ligation (PSNL). The antinociceptive effects of 1 and 3 were attributed to the regulatory effects of their bioactive compounds on inflammatory mediators. As for 2 and 5, their analgesic effect may be a result of their activity with the 5-hydroxytryptamine 1A receptor (5-HT1AR) which disrupted the pain-stimulating actions of 5-HT. Antinociceptive activities were documented for various major compounds of the Litsea plants. Overall, the findings suggested Litsea species as good sources of antinociceptive compounds that can be further developed to complement or substitute prescription drugs for pain management.

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Section: % Ethanolic Leaf Extractmentioning

confidence: 99%

The Analgesic Potential of Litsea Species: A Systematic Review

Goh,

Samsul,

Mohaimin

et al. 2024

Molecules

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“…Molecules 2024, 29, 1626 2 of 11 from fresh fruits has a citral content of approximately 60-90% [2,3]. In fact, several researchers have documented the bioactive properties of LCEO, which include antioxidant, antimicrobial, antifungal, anti-inflammatory and insecticidal properties [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Inclusion Complexes of Litsea cubeba (Lour.) Pers Essential Oil into β-Cyclodextrin: Preparation, Physicochemical Characterization, Cytotoxicity and Antifungal Activity

Pante,

Castro,

Lini

et al. 2024

Molecules

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The uses of natural compounds, such as essential oils (EOs), are limited due to their instability to light, oxygen and temperature, factors that affect their application. Therefore, improving stability becomes necessary. The objective of this study was to prepare inclusion complexes of Litsea cubeba essential oil (LCEO) with β-cyclodextrin (β-CD) using physical mixing (PM), kneading (KN) and co-precipitation (CP) methods and to evaluate the efficiency of the complexes and their physicochemical properties using ATR-FTIR, FT-Raman, DSC and TG. The study also assessed cytotoxicity against human colorectal and cervical cancer cells and antifungal activity against Aspergillus flavus and Fusarium verticillioides. The complexation efficiency results presented significant evidence of LCEO:β-CD inclusion complex formation, with KN (83%) and CP (73%) being the best methods used in this study. All tested LCEO:β-CD inclusion complexes exhibited toxicity to HT-29 cells. Although the cytotoxic effect was less pronounced in HeLa tumor cells, LCEO-KN was more active against Hela than non-tumor cells. LCEO-KN and LCEO-CP inclusion complexes were efficient against both toxigenic fungi, A. flavus and F. verticillioides. Therefore, the molecular inclusion of LCEO into β-CD was successful, as well as the preliminary biological results, evidencing that the β-CD inclusion process may be a viable alternative to facilitate and increase future applications of this EO as therapeutic medication, food additive and natural antifungal agent.

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“…It is widely distributed in southern China and other areas of Southeast Asia [3,4]. The plant as a whole has a unique fragrance, but the essential oil is extracted mainly from the fruit [5]. The oil is used in a variety of applications, and the fruit is a common herbal medicine [6].…”

Section: Introductionmentioning

confidence: 99%

Main Habitat Factors Driving the Phenotypic Diversity of Litsea cubeba in China

Liao,

Ning,

Yang

et al. 2023

Plants

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Litsea cubeba (Lour.) Pers. is an important woody spice tree in southern China, and its fruit is a rich source of valuable essential oil. We surveyed and sampled L. cubeba germplasm resources from 36 provenances in nine Chinese provinces, and detected rich phenotypic diversity. The survey results showed that plants of SC-KJ, SC-HJ, and SC-LS provenance presented higher leaf area (LA); YN-SM and YN-XC plants had larger thousand-grain fresh weight (TFW); and HN-DX plants had the highest essential oil content (EOC). To explain the large differences in the phenotypes of L. cubeba among different habitats, we used Pearson’s correlation analysis, multiple stepwise regression path analysis, and redundancy analysis to evaluate the phenotypic diversity of L. cubeba. It was found that compared to other traits, leaf and fruit traits had more significant geographical distributions, and that leaf phenotypes were correlated to fruit phenotypes. The results showed that elevation, latitude, longitude, total soil porosity (SP), soil bulk density (SBD), and average annual rainfall (AAR, mm) contributed significantly to the phenotypic diversity of L. cubeba. Geographical factors explained a higher percentage of variation in phenotypic diversity than did soil factors and climate factors. Plants of SC-KJ and HN-DX provenances could be important resources for domestication and breeding to develop new high-yielding varieties of this woody aromatic plant. This study describes significant phenotypic differences in L. cubeba related to adaptation to different environments, and provides a theoretical basis for the development of a breeding strategy and for optimizing L. cubeba cultivation.

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The composition, pharmacological and economic importance of essential oil of Litsea cubeba (Lour.) Pers

Cited by 5 publications

References 39 publications

The Analgesic Potential of Litsea Species: A Systematic Review

The Analgesic Potential of Litsea Species: A Systematic Review

Inclusion Complexes of Litsea cubeba (Lour.) Pers Essential Oil into β-Cyclodextrin: Preparation, Physicochemical Characterization, Cytotoxicity and Antifungal Activity

Main Habitat Factors Driving the Phenotypic Diversity of Litsea cubeba in China

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