Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells

Zhao, Yongmei; Cheng, Qi; Shen, Zizhu; Fan, Bin; Xu, Yan; Cao, Yuting; Peng, Fanxi; Zhao, Jingkai; Xue, Bin

doi:10.1590/fst.35719

Cited by 9 publications

(3 citation statements)

References 36 publications

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“…Prodigiosins are pH-sensitive, photosensitive, insoluble in water, sparingly soluble in alcohol and ether, and soluble in chloroform, methanol, acetonitrile, and DMSO (88)(89)(90) . Although the mechanism by which these compounds act, is complex and probably multifactorial, a wide variety of studies have demonstrated important pigment-associated properties.…”

Section: Prodigininesmentioning

confidence: 99%

Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review

2022

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Natural bioactive compounds obtained from microorganisms, have awakened particular interest in the industry nowadays. This attention comes when natural resources depletion is pronounced, and the acquisition of both new plant origin resources and bioactive products, represents a challenge for the next generations. In this sense, prospecting for large-scale production and use of bacterial pigments is a necessary strategy for the development of novel products. A wide variety of properties have been attributed to these substances and, among them, their therapeutic potential against important diseases, such as cancer. There is consensus that available chemotherapy protocols are known to detrimentally affect cancer patients fertility. Hence, considerable part of the deleterious effects of chemotherapy is related to the drugs cytotoxicity, which, in addition to cancer cells, also affect normal cells. Therefore, the intrinsic properties of bacterial pigments associated with low cytotoxicity and relevant cell selectivity, certified them as potential anticancer drugs. However, little information is available about reproductive toxicity of these new and promising compounds. Thus, the present review aims to address the main bacterial pigments, their potential uses as anticancer drugs and their possible toxic effects, especially on the female gonad.

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Section: Prodigininesmentioning

confidence: 99%

Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review

2022

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“…As prodigiosinas apresentam coloração sensível ao pH, são fotossensíveis, insolúveis em água, moderadamente solúveis em álcool e éter e solúveis em clorofórmio, metanol, acetonitrila e DMSO (88)(89)(90) . Embora o mecanismo pelo qual esses compostos agem seja complexo e, provavelmente multifatorial, uma ampla variedade de estudos demonstrou importantes propriedades associadas ao pigmento.…”

Section: Prodigininasunclassified

Uso potencial de pigmentos bacterianos como drogas anticâncer e toxicidade reprodutiva feminina: uma revisão

2022

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Resumo Os compostos bioativos naturais obtidos de microrganismos têm despertado especial interesse da indústria nos últimos anos. Esta atenção ocorre em um momento em que o esgotamento de recursos naturais é pronunciado, e a aquisição de novos insumos e produtos bioativos de origem vegetal representa um desafio para as próximas gerações. Neste sentido, a prospecção para a produção e uso em larga escala dos pigmentos bacterianos tem representado uma importante estratégia para o desenvolvimento de novos produtos. Uma grande variedade de propriedades foi atribuída a estas substâncias, entre elas, o potencial terapêutico contra doenças importantes, como o câncer. Existe um consenso de que os protocolos quimioterápicos disponíveis são conhecidos por afetarem negativamente a fertilidade de pacientes com câncer. Grande parte dos efeitos deletérios da quimioterapia está relacionado à citotoxicidade das drogas usadas para este fim, que além das células cancerosas, afetam as células normais. Nesse sentido, as propriedades naturais atribuídas aos pigmentos bacterianos associadas à baixa citotoxicidade e relevante seletividade, os qualificaram como potenciais drogas anticâncer. No entanto, pouco se tem de informação a respeito da toxicidade reprodutiva destes novos e promissores compostos. Dessa forma, a presente revisão tem o objetivo de abordar os principais pigmentos bacterianos, suas utilizações potenciais como drogas anticâncer, bem como os seus possíveis efeitos tóxicos, sobretudo, sobre a gônada feminina.

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“…Prodigiosin merupakan metabolit sekunder yang termasuk ke dalam golongan alkaloid dengan struktur kimia tripyrrole yang unik. Biasanya prodigiosin berbentuk pigmen merah yang diisolasi dari Serratia, Pseudomonas dan Streptomyces [15]. Alkaloid memiliki bioaktivitas sebagai antibakteri.…”

Section: Uji Fitokimiaunclassified

Analisis Senyawa Bioaktif Ekstrak Metabolit Sekunder Serratia marcescens strain MBC1

Variani

Setyaningrum

Handayani

et al. 2021

IJCA

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Serratia marcescens strain MBC1 merupakan bakteri gram negatif yang dapat menghasilkan beberapa senyawa bioaktif. Berdasarkan penelitian sebelumnya, diketahui bahwa bakteri ini mampu mendegradasi berbagai macam enzim dan memiliki berbagai macam aktivitas biologis seperti antibakteri, antikanker, biosurfaktan dan sebagai bahan obat-obatan. Tujuan penelitian ini adalah untuk mengetahui kandungan senyawa bioaktif yang terdapat pada ekstrak metabolit sekunder Serratia marcescens strain MBC1. Pada penelitian ini dilakukan beberapa uji yaitu, uji fitokomia dan uji FT-IR. Hasil uji fitokimia menunjukkan bahwa ekstrak Serratia marcescens strain MBC1 mengandung senyawa golongan alkaloid dan saponin. Hasil uji FT-IR menunjukkan adanya kemiripan gugus fungsi yang dimiliki oleh ekstrak S.marcescens strain MBC1 dengan senyawa golongan alkaloid. Namun, perlu adanya penelitian lebih lanjut mengenai kandungan senyawa metabolit yang terkandung dalam ekstrak S. marcescens dan aktivitas biologisnya sebagai antimalaria, antibakteri, antifungi dan sebagai bahan obat-obatan.

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Structure of prodigiosin from Serratia marcescens NJZT-1 and its cytotoxicity on TSC2-null cells

Cited by 9 publications

References 36 publications

Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review

Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review

Uso potencial de pigmentos bacterianos como drogas anticâncer e toxicidade reprodutiva feminina: uma revisão

Analisis Senyawa Bioaktif Ekstrak Metabolit Sekunder Serratia marcescens strain MBC1

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