Preparation of beta-carotene nanoemulsion and evaluation of stability at a long storage period

Moreira, Juliana Botelho; Goularte, Pâmela Guder; Morais, Michele Greque de; Costa, Jorge Alberto Vieira

doi:10.1590/fst.31317

Cited by 20 publications

(8 citation statements)

References 28 publications

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“…The particles of the nanoemulsions were spherical, and the average particle size measured using TEM was in line with the average size determined from the photon correlation spectroscopy. The stability of the nanoemulsion system would increase when the polydispersity index (PDI) value was minimized, whereas the Ostwald ripening due to repulsive interaction between the particles during storage could be reduced when the ζ -potential value was maximized [ 31 ]. The PDI and ζ -potential values for both optimized formulations were in the range 0.22–0.25 and greater than −30 mV, respectively.…”

Section: Resultsmentioning

confidence: 99%

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Asmawi

Salim

Abdulmalek

et al. 2020

IJMS

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The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized nanoemulsion system for pulmonary delivery is recommended to mitigate these drawbacks. In this study, DTX- and CCM-loaded nanoemulsions were optimized using the D-optimal mixture experimental design (MED). The effect of nanoemulsion compositions towards two response variables, namely, particle size and aerosol size, was studied. The optimized formulations for both DTX- and CCM-loaded nanoemulsions were determined, and their physicochemical and aerodynamic properties were evaluated as well. The MED models achieved the optimum formulation for DTX- and CCM-loaded nanoemulsions containing a 6.0 wt% mixture of palm kernel oil ester (PKOE) and safflower seed oils (1:1), 2.5 wt% of lecithin, 2.0 wt% mixture of Tween 85 and Span 85 (9:1), and 2.5 wt% of glycerol in the aqueous phase. The actual values of the optimized formulations were in line with the predicted values obtained from the MED, and they exhibited desirable attributes of physicochemical and aerodynamic properties for inhalation therapy. Thus, the optimized formulations have potential use as a drug delivery system for a pulmonary application.

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Section: Resultsmentioning

confidence: 99%

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Asmawi

Salim

Abdulmalek

et al. 2020

IJMS

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“…The homogeneity attribute received the highest mean of the evaluators, with mean values above 7.0. These attributes probably received these assessments due to the fact that cheese from goat's milk has a whiter color, due to the lack of carotene, since all the B-carotene is converted into vitamin A (Moreira et al, 2019), and, for not having suffered any deleterious effects during the cheese production and storage processes.…”

Section: Resultsmentioning

confidence: 99%

The impact of double-distilled glycerin supplementation on the quality of goat milk and cheese

et al. 2022

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The objective of this study was to evaluate the effects of replacing corn by double-distilled glycerin, a co-product of the biodiesel industry, on goat curd cheese in terms of physical-chemical, microbiological and sensory aspects. Twelve multiparas Saanen goats weighing 47.07 ± 2.41 kg and at 90 ± 5 days of lactation. The experimental design was completely randomized with two treatments (0 and 15% inclusion of glycerin). The physicochemical parameters analyzed were: fat (%), non-fat solids (%), protein (%), lactose (%), salts (%), relative density at 15/15 °C (gmL-1), index cryoscopic (°C), electrical conductivity (mScm-1), pH and acidity. The milk from each treatment was used to make the rennet cheese. The fat had a significant effect (P < 0.05) with inclusion of glycerin in the diet. The physicochemical characteristics of the cheese were influenced (P < 0.05) by feeding up to 15% of glycerin. Regarding sensory attributes, only firmness was influenced (P < 0.05) by the inclusion of glycerin in the diet of dairy goats. Bidistilled glycerin, when inserted in the diet of dairy goats at a level of 15%, causes a reduction in the lipid content of milk and cheese, consequently affecting the cheese yield, and the parameter of firmness in the sensory of the evaluated cheeses.

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“…The large particle sizes are formed at the high stirring rates in the systems where the surfactant is not suitable, thus facilitating the transport of molecular mass into larger lumps. However, the stable emulsion can be produced on the appropriate agitation speed and suitable surfactants as conducted by Moreira et al [22]. The formation of stable beta-carotene nanoemulsion was obtained with a surfactant concentration of 7 %wt, soy lecithin as a suitable surfactant, 10,000 rpm of agitation speed, and 5-20 minutes of agitation time.…”

Section: A Particle Size Reduction Of Emulsions With Homogenizermentioning

confidence: 99%

“…Moreira et al [22] stated that high surfactant concentration, high, stirring speed, and a certain emulsification temperature made the particle size of the emulsion smaller so that the emulsion stability was achieved [31].…”

Section: Characterization Of Andaliman Aroma Compound Nanoemulsionmentioning

confidence: 99%

Synthesis and Characterization of Nanoemulsion Andaliman Aroma Compound

Rienoviar¹,

Setyangingsih²,

Sudirman³

et al. 2021

Int. J. Adv. Sci. Eng. Inf. Technol.

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Andaliman is widely used in culinary and medicine for a long time ago. However, it has a short storage life, so it takes a preservation process. The study aims to create the synthesis of the Andaliman aroma compound and its characterization. The synthesis process is conducted with several variables such as oleoresin concentration range of 10 and 20 wt% and type of surfactants such as Tween 80, mixed of Tween 80:20 (50:50 wt%) and Tween 20. The homogeneous Maltodextrin solution and gum Arabic solution, called solution 1 and 2, are created by using ultra turrax with a speed of 18,000 rpm for 5 minutes. Then they are mixed with a comparative composition 2:3 as wall material. After that, the mixture is added by three different types of surfactants such as Tween 80, mixed Tween 80 and 20 (1:1), and Tween 20. Andaliman nanoemulsion is generated by mixing Andaliman oleoresin, wall materials, and water with two different compositions, such as 10:20:100 and 20:20:100 and also nine wt% of surfactants. Their treatment mixing is similar to the manufacture of wall materials. The characterization of nano emulsification was conducted by analyzing droplet size, zeta potential, polydispersity index (PDI), emulsion stability index (ESI), and viscosity. The study results showed that mixed 20 wt% oleoresin concentration and emulsifier of Tween 20 produced 100% of ESI value with a particle size of 68.5 nm and zeta potential of -44.95 in which showed the stability of both emulsion and nanometer-sized particle.

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Preparation of beta-carotene nanoemulsion and evaluation of stability at a long storage period

Cited by 20 publications

References 28 publications

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design

The impact of double-distilled glycerin supplementation on the quality of goat milk and cheese

Synthesis and Characterization of Nanoemulsion Andaliman Aroma Compound

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