Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways

LIU, Qiyun; FU, Qian; Du, Jia; LIU, Xiaohui

doi:10.1590/fst.31121

Cited by 1 publication

(1 citation statement)

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“…Additionally, the inhibitory effects of allicin on cardiac hypertrophy in rats can also be mediated by the inhibition of apoptosis and the stimulation of angiogenesis [ 95 ]. In cell cultures of cardiomyocyte allicin increase the expression of PPARα, PPARγ, and Bcl-2, and downregulate Bax, Fas, and Fax-L, these effects were induced by Angiotensin II stimulation and suggested that allicin can regulate apoptosis and ventricular remodeling [ 96 ].…”

Section: Effects Of Allicin On Cardiovascular Risk Factorsmentioning

confidence: 99%

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Sánchez-Gloria

Arellano‐Buendía

Juárez-Rojas

et al. 2022

IJMS

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Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors.

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Section: Effects Of Allicin On Cardiovascular Risk Factorsmentioning

confidence: 99%