Protective Effect of Victory Onion (Allium victorialis L.) Extract on Reproductive System Injury in Male Rats

Li, Fanzhu; Zhang, Xian; Ameer, Kashif; Eun, Jong‐Bang

doi:10.1590/fst.30220

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…In addition, quercetin-3- O -glucoside and kaempferol-3- O -glucoside-rich Erica multiflora extract can improve the enzymatic activities of SOD, CAT, and glutathione peroxidase (GPx), as well as reduce oxidative stress by reducing the levels of MDA in Wistar rats fed high-fat and fructose diet [ 18 ]. In a hydrocortisone-induced kidney yang deficiency mouse model, treatment with A. victorialis aqueous extract resulted in improved kidney yang deficiency by reducing changes in an increase of MDA and a decrease of SOD [ 19 ]. In addition, the release of ALT and AST into the medium in ethanol-induced HepG2 cells was significantly inhibited by quercetin, quercetin-3-glucoside, and rutin, major components of A. ochotense [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Go,

Kim,

Lee

et al. 2024

IJMS

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This study was performed to investigate the protective effects of Allium ochotense on fatty liver and hepatitis in chronic alcohol-induced hepatotoxicity. The physiological compounds of a mixture of aqueous and 60% ethanol (2:8, w/w) extracts of A. ochotense (EA) were identified as kestose, raffinose, kaempferol and quercetin glucoside, and kaempferol di-glucoside by UPLC Q-TOF MSE. The EA regulated the levels of lipid metabolism-related biomarkers such as total cholesterol, triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL)-cholesterol in serum. Also, EA ameliorated the levels of liver toxicity-related biomarkers such as glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and total bilirubin in serum. EA improved the antioxidant system by reducing malondialdehyde contents and increasing superoxide dismutase (SOD) levels and reduced glutathione content. EA improved the alcohol metabolizing enzymes such as alcohol dehydrogenase, acetaldehyde dehydrogenase, and cytochrome P450 2E1 (CYP2E1). Treatment with EA alleviated lipid accumulation-related protein expression by improving phosphorylation of AMP-activated protein kinase (p-AMPK) expression levels. Especially, EA reduced inflammatory response by regulating the toll-like receptor–4/nuclear factor kappa-light-chain-enhancer of activated B cells (TLR-4/NF-κB) signaling pathway. EA showed an anti-apoptotic effect by regulating the expression levels of B-cell lymphoma 2 (BCl-2), BCl-2-associated X protein (BAX), and caspase 3. Treatment with EA also ameliorated liver fibrosis via inhibition of transforming growth factor-beta 1/suppressor of mothers against decapentaplegic (TGF-β1/Smad) pathway and alpha-smooth muscle actin (α-SMA). Therefore, these results suggest that EA might be a potential prophylactic agent for the treatment of alcoholic liver disease.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Go,

Kim,

Lee

et al. 2024

IJMS

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“…Onion comprises of moisture (ranging from 88.6% to 92.8%), fat trace (0.2%), ash (0.6%), and carbohydrates (ranging from 5.2% to 9.1%) (Bogevska et al, 2016 ; Griffiths et al, 2002 ; Jiang et al, 2021 ). The majority of the compositional framework of onion comprises dry matter content having nonstructural carbohydrates, such as fructans, sucrose, fructose, and glucose (Li et al, 2020 ; Yang et al, 2021 ). The sugar content of onion is subjected to variability during storage depending on storage temperature, postharvest treatments, and cultivar type.…”

Section: Introductionmentioning

confidence: 99%

Optimization of spray drying process for recovery of onion–stevia leaf hot water extract powder using response surface methodology

Yang

Ameer

Chung³

et al. 2023

Food Science & Nutrition

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It is important to optimize the drying process, along with the concentration of drying aid and the inlet air temperature, in order to obtain products with better physicochemical properties. Onion–stevia leaf hot extract powders were prepared using gum arabic (GA) and whey protein concentrate (WPC). Inlet air temperature and carrier concentrations were optimized using response surface methodology. The drying yield of powdered extracts was 14.39–74.32%, L*‐ value was 52.66–66.98, bulk density was 0.36–0.75 (g/cm3), moisture content was 2.40–11.57%, water solubility index was 30.32%–97.46%, and mean particle size D[4,3] was 9.13–88.01 (μm). For both GA‐ and WPC‐based powders, optimal inlet air temperatures and carrier concentrations were 148.81 and 144.62°C, and 11.58 and 12.03% (w/v), respectively. GA powders had a higher glass transition temperature (76.49°C) as compared to WPC powders (48.12°C) or maltodextrin as control (55.49°C). Sweetness (5.0/7.0) and overall acceptability (4.3/7.0) scores were higher for GA powders as compared to WPC powders (3.7/7.0 and 3.4/7.0), respectively. Conclusively, GA is a better carrier than whey protein for preparing spray‐dried onion–stevia powder that can be used as a natural sweetener.

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“…These molecules are exacerbating factors in cellular injury and aging processes. In foods, ROS can cause lipid peroxidation, which leads to the deterioration of the foodstuffs (Li et al, 2020 ; Yang et al, 2021 ). The oxidative deterioration of lipid‐containing foods is responsible for the rancid odors and flavors during processing and storage, consequently decreasing the nutritional quality and safety of foods due to the formation of potentially toxic secondary compounds.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling, antimicrobial, and antioxidant activities of hydroethanolic extracts of prickly pear (Opuntia ficus indica) fruit and pulp

Iftikhar

Siddique

Ameer

et al. 2023

Food Science & Nutrition

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Phenolic compounds in prickly pear [Opuntia ficus indica (L.) Mill.] are known to contribute to the antioxidant and antimicrobial activities of the prickly pear. The present study aimed to evaluate the antioxidants and in vitro antimicrobial potential in the hydroethanolic extracts of different parts (fruit, cladode, and pulp) of prickly pear. Different polyphenolic compounds were analyzed by using high‐performance liquid chromatography. The results indicated that cladode possessed a higher quantity of phenolics compared with that observed in fruit and pulp. The most important phenolic compound in high quantity was gallic acid (66.19 μg/g) in cladode. The 100% aqueous extract of cladode exhibited the highest antioxidant (92%) and antimicrobial activities against Salmonella typhi (3.40 mg/ml), Helicobacter pylori (1.37 mg/ml), Escherichia coli (1.41 mg/ml), and Staphylococcus aureus (1.41 mg/ml). Principal component analysis (PCA) indicated that antioxidant activity and minimum inhibitory concentration (MIC) responses had a significant negative correlation with each other. Overall, the current results provided basic data for choosing prickly pear cladode with high antioxidant capacity for the development and consumption of antioxidant‐based alternative medicines and value addition of formulated foods.

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Protective Effect of Victory Onion (Allium victorialis L.) Extract on Reproductive System Injury in Male Rats

Cited by 3 publications

References 13 publications

Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice

Optimization of spray drying process for recovery of onion–stevia leaf hot water extract powder using response surface methodology

Phytochemical profiling, antimicrobial, and antioxidant activities of hydroethanolic extracts of prickly pear (Opuntia ficus indica) fruit and pulp

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